1-Isothiocyanato-6-(methylsulfinyl)-hexane
- CAS No.
- 4430-35-7
- Chemical Name:
- 1-Isothiocyanato-6-(methylsulfinyl)-hexane
- Synonyms
- 6-MITC;6-HITC;6-MITC; 6 MITC; 6MITC;6-METHYLSULFINYLHEXYL ISOTHIOCYANATE;1-Isothiocyanato-6-(methylsulfinyl)-hexane;Hexane, 1-isothiocyanato-6-(methylsulfinyl)-;6-(Methylsulfinyl)hexyl isothiocyanate (6-MITC), tumor cell proliferation inhibitor
- CBNumber:
- CB4774237
- Molecular Formula:
- C8H15NOS2
- Molecular Weight:
- 205.34
- MDL Number:
- MFCD03093720
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 385.9±25.0 °C(Predicted) |
|---|---|
| Density | 1.12±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator, under inert atmosphere |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| form | Oil |
| color | Colourless to Pale Yellow |
| LogP | 0.959 (est) |
| FDA UNII | 8RUP6Q3JBB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
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1-Isothiocyanato-6-(methylsulfinyl)-hexane price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3554 | 6-(Methylsulfinyl)hexyl isothiocyanate ≥98% (HPLC) | 4430-35-7 | 5MG | $89.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3554 | 6-(Methylsulfinyl)hexyl isothiocyanate ≥98% (HPLC) | 4430-35-7 | 25MG | $360 | 2026-04-30 | Buy |
| Cayman Chemical | 19638 | 6-Methylsulfinylhexyl isothiocyanate ≥98% | 4430-35-7 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 19638 | 6-Methylsulfinylhexyl isothiocyanate ≥98% | 4430-35-7 | 5mg | $135 | 2026-04-30 | Buy |
| Cayman Chemical | 19638 | 6-Methylsulfinylhexyl isothiocyanate ≥98% | 4430-35-7 | 10mg | $203 | 2026-04-30 | Buy |
1-Isothiocyanato-6-(methylsulfinyl)-hexane Chemical Properties,Uses,Production
Description
6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities. It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 μM. It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC50 = 21.9 μM). 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC50 = 43.7 μM). In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson''s disease induced by 6-OHDA . 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.
Uses
6-(Methylsulfinyl)hexyl isothiocyanate derived from Wasabia japonica was discovered as an inhibitor of glycogen synthase kinase-3β.
Definition
ChEBI: 1-isothiocyanato-6-(methylsulfinyl)hexane is a sulfoxide.
in vivo
Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) activates Nrf2 and induces phase II enzyme genes but this induction is absent in Nrf2-null mice, suggesting that Hesperin is a potential activator of the Nrf2/ARE-dependent detoxification pathway. To determine whether Hesperin ameliorates hepatic steatosis and iron accumulation, wild-type and Nrf2-null mice are fed the following diets for 12 weeks: 1) control diet, 2) high-fat diet (HFD), 3) HFD plus Hesperin (10 mg/kg/day ip), 4) HFD for 6 weeks followed by an iron-supplemented HFD for 6 weeks (HFD/Iron), 5) HFD/Iron plus Hesperin. The HFD increased hepatic triglycerides in both genotypes and Hesperin suppress increased hepatic triglycerides in wild-type mice but do not reduce these triglycerides in Nrf2-null mice[1].
References
[1] TOSHIRO NOSHITA . Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity[J]. European Journal of Medicinal Chemistry, 2009, 44 12: Pages 4931-4936. DOI: 10.1016/j.ejmech.2009.08.005
[2] YASUJIRO MORIMITSU . Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabi[J]. Mechanisms of Ageing and Development, 2000, 116 2: Pages 125-134. DOI: 10.1016/s0047-6374(00)00114-7
[3] TAKAHIRO NOMURA PHD . Selective sensitivity to wasabi-derived 6-(methylsulfinyl)hexyl isothiocyanate of human breast cancer and melanoma cell lines studied in vitro[J]. Cancer Epidemiology, 2005, 29 2: Pages 155-160. DOI: 10.1016/j.cdp.2004.07.010
[4] FABIANA MORRONI . Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinsons disease[J]. Brain Research, 2014, 1589: Pages 93-104. DOI: 10.1016/j.brainres.2014.09.033
[5] YOKO FUKE PHD . Preventive effect of oral administration of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum) against pulmonary metastasis of B16-BL6 mouse melanoma cells[J]. Cancer Epidemiology, 2006, 30 2: Pages 174-179. DOI: 10.1016/j.cdp.2005.10.005
1-Isothiocyanato-6-(methylsulfinyl)-hexane Preparation Products And Raw materials
Raw materials
Preparation Products
1-Isothiocyanato-6-(methylsulfinyl)-hexane Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| YouCoChem (Beijing) Chemical Technology Co., Ltd. | 18800159827 | youcochem@163.com | China | 163 | 50 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-85201366 18938635012 | sales@regentsciences.com | China | 9385 | 58 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
