Hederagenin
- CAS No.
- 465-99-6
- Chemical Name:
- Hederagenin
- Synonyms
- hederagenol;Hederidin;NSC 24954;HEDERAGENIN;Hederogenin;Rangefinder;Hederagenine;MELANTHIGENIN;Vaccaric acid;Kalosapogenin
- CBNumber:
- CB8739586
- Molecular Formula:
- C30H48O4
- Molecular Weight:
- 472.71
- MDL Number:
- MFCD00017385
- MOL File:
- 465-99-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 332-334° |
|---|---|
| alpha | D20 +81° (c = 0.7 in pyridine) |
| Boiling point | 493.44°C (rough estimate) |
| Density | 0.9871 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | methanol: soluble1mg/mL |
| pka | 4.63±0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| λmax | 405nm(H2SO4)(lit.) |
| Merck | 14,4624 |
| InChIKey | PGOYMURMZNDHNS-MYPRUECHSA-N |
| SMILES | C[C@@]12CC[C@]3(CCC(C)(C)C[C@@]3([H])C1=CC[C@]1([H])[C@]3(CC[C@H](O)[C@@](C)(CO)[C@]3([H])CC[C@@]21C)C)C(=O)O |&1:1,4,11,16,18,21,23,27,31,r| |
| LogP | 7.410 (est) |
| FDA UNII | RQF57J8212 |
| UNSPSC Code | 41116107 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312+P330-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-45-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29181990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
Hederagenin price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | H3916 | Hederagenin ≥97% (HPLC) | 465-99-6 | 10mg | $523 | 2026-04-30 | Buy |
| TCI Chemical | H1645 | Hederagenin >98.0%(HPLC)(T) | 465-99-6 | 50mg | $149 | 2026-04-30 | Buy |
| TCI Chemical | H1645 | Hederagenin >98.0%(HPLC)(T) | 465-99-6 | 200mg | $514 | 2026-04-30 | Buy |
| Cayman Chemical | 27030 | Hederagenin ≥98% | 465-99-6 | 50mg | $160 | 2026-04-30 | Buy |
| Cayman Chemical | 27030 | Hederagenin ≥98% | 465-99-6 | 100mg | $304 | 2026-04-30 | Buy |
Hederagenin Chemical Properties, Uses, Production
Description
Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells. In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP.
Chemical Properties
White Solid
Uses
Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells.
Definition
ChEBI: A sapogenin that is olean-12-en-28-oic acid substituted by hydroxy groups at positions 3 and 23 (the 3beta stereoisomer).
in vivo
Hederagenin (25 mg/kg; po; 11 d) alone did not affect tumor growth in NCI-H1299 xenograft mice. However, it has a synergistic effect with Cisplatin (1 mg/kg) to inhibit tumor growth[4].
Hederagenin (50 mg/kg; po; once daily for 21 days) exerts anti-inflammatory and anti-apoptotic activities and reduces liver damage induced by 25% ethanol in mice[5].
References
[1] LALITH JAYASINGHE . Hederagenin glycosides from Pometia eximia[J]. Phytochemistry, 1995, 40 3: Pages 891-897. DOI: 10.1016/0031-9422(95)00360-j
[2] EUN HYE KIM. Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway.[J]. Oxidative Medicine and Cellular Longevity, 2017: 5498908. DOI: 10.1155/2017/5498908
[3] SU-HONG LU. Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats[J]. Evidence-based Complementary and Alternative Medicine, 2015, 35 1. DOI: 10.1155/2015/456354
[4] GYEONG-JI KIM. Hederagenin Supplementation Alleviates the Pro-Inflammatory and Apoptotic Response to Alcohol in Rats[J]. Nutrients, 2017. DOI: 10.3390/nu9010041
[5] AN-GUO WU . Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice[J]. Pharmacological research, 2017, 115: Pages 25-44. DOI: 10.1016/j.phrs.2016.11.002
Hederagenin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6904 | 55 |
| Nanjing Spring & Autumn Biological Engineering Co., Ltd. | 17388075642 13815430202 | sale02@cqherb.com | China | 261 | 59 |
| Naturewill Biotechnology Co., Ltd. | 028-82632533 18113192475 | 3157321941@qq.com | China | 4993 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Shenzhen Sungening Bio-Tech Co., Ltd | +86-0755-89668383 | sales@sungening.com | China | 1319 | 65 |
View Latest Price from Hederagenin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-22 | Hederagenin
465-99-6
|
$35.00 | 99.11% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Hederagenin
465-99-6
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
 |
2023-02-24 | Hederagenin
465-99-6
|
5mg | Analytical Standard | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Hederagenin
465-99-6
- $35.00
- 99.11%
- TargetMol Chemicals Inc.
-
- Hederagenin
465-99-6
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Hederagenin
465-99-6
- $0.00
- Analytical Standard
- Shanghai Standard Technology Co., Ltd.
