Ethyl 3,6-dichloropyridazine-4-carboxylate
- CAS No.
- 34127-22-5
- Chemical Name:
- Ethyl 3,6-dichloropyridazine-4-carboxylate
- Synonyms
- Ethyl 3,6-dichloropyridazine-4-carboxylate;3,6-Dichloro-5-ethylpyridazine-4-carbaldehyde;3,6-Dichloropyridazine-4-carboxylic acid ethyl ester;4-Pyridazinecarboxylic acid, 3,6-dichloro-, ethyl ester;ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE ISO 9001：2015 REACH
- CBNumber:
- CB4836667
- Molecular Formula:
- C7H6Cl2N2O2
- Molecular Weight:
- 221.04
- MDL Number:
- MFCD08704423
- MOL File:
- 34127-22-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H315-H319 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
Ethyl 3,6-dichloropyridazine-4-carboxylate price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | JBA12722 | Ethyl 3,6-dichloropyridazine-4-carboxylate | 34127-22-5 | 10g | $472 | 2026-06-04 | Buy |
| Matrix Scientific | 083513 | Ethyl 3,6-dichloropyridazine-4-carboxylate | 34127-22-5 | 1.00g | $874 | 2026-05-18 | Buy |
| Synthonix | E38355 | Ethyl 3,6-dichloropyridazine-4-carboxylate 95+% | 34127-22-5 | 100mg | $79 | 2026-05-06 | Buy |
| Synthonix | E38355 | Ethyl 3,6-dichloropyridazine-4-carboxylate 95+% | 34127-22-5 | 250mg | $93 | 2026-05-06 | Buy |
| Synthonix | E38355 | Ethyl 3,6-dichloropyridazine-4-carboxylate 95+% | 34127-22-5 | 1g | $97 | 2026-05-06 | Buy |
Ethyl 3,6-dichloropyridazine-4-carboxylate Chemical Properties, Uses, Production
Synthesis
64-17-5
51149-08-7
34127-22-5
To a suspension of 3,6-dichloropyridazine-4-carboxylic acid (15.0 g, 78 mmol) in tetrahydrofuran (THF, 150 mL) was sequentially added ethanol (18.15 mL, 311 mmol) and 4-dimethylaminopyridine (DMAP, 0.950 g, 7.77 mmol). 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC, 16.39 g, 85 mmol) was added in batches over 1 min, and mild exothermic phenomena were observed during the reaction. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the mixture was transferred to a dispensing funnel and neutralized by adding saturated aqueous sodium bicarbonate (NaHCO3) solution (150 mL). The aqueous phase was extracted with ether (3×250 mL), and the combined organic phases were washed with saturated saline (100 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 20%→40% ethyl acetate/hexane solution; amount of silica gel: 300 g) to afford ethyl 3,6-dichloro-4-pyridazine-carboxylate (13.2 g, 59.7 mmol, 77% yield) as a colorless oil. The product was characterized as follows: 1H NMR (400 MHz, CDCl3) δ 7.88 (s, 1H), 4.50 (q, J = 7.0 Hz, 2H), 1.46 (t, J = 7.2 Hz, 3H); LCMS (ESI) m/e 221.1 [(M + H)+, theoretical value 221.0 (C7H7Cl2N2O2)].
References
[1] Patent: WO2018/98411, 2018, A1. Location in patent: Page/Page column 20; 21; 23; 24; 68; 69
[2] Patent: WO2008/130951, 2008, A1. Location in patent: Page/Page column 81
[3] Journal of Medicinal Chemistry, 1993, vol. 36, # 18, p. 2676 - 2688
[4] Patent: WO2008/130600, 2008, A2. Location in patent: Page/Page column 70
[5] Patent: WO2004/108707, 2004, A1. Location in patent: Page 53-54
Ethyl 3,6-dichloropyridazine-4-carboxylate Preparation Products And Raw materials
Ethyl 3,6-dichloropyridazine-4-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Jiangsu Mingchem Corporation | 0519-85170101 | sales@mingchem.com | China | 632 | 55 |
| Struchem Co., Ltd. | 0512-63009836 18994340901 | helen@struchem.com | China | 3970 | 60 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Shanghai Rlavie Technology Co., Ltd. | 021-67759270 17717059219 | sales@rlavie.com | China | 1850 | 55 |
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4966 | 58 |
| Linyi Azelasi Biological Co., Ltd. | 17753923223; | 2805221329@qq.com | China | 1472 | 58 |
| Zhengzhou Ruke Biological Co., Ltd. | 15981811963 | 1410472904@qq.com | China | 5824 | 58 |
| Henan Aosman Biotechnology Co., LTD | 13761588971 17719817155 | 2366079749@qq.com | China | 3009 | 58 |
| Tianjin Zhongcheng Mingyuan Technology Co., Ltd. | 13302022156 | 3506745780@qq.com | China | 168 | 58 |
View Latest Price from Ethyl 3,6-dichloropyridazine-4-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-08-07 | Ethyl 3,6-dichloropyridazine-4-carboxylate
34127-22-5
|
$1.00 | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2022-01-04 | 3,6-Dichloropyridazine-4-carboxylic acid ethyl ester
34127-22-5
|
1g | 98%minHPLC | 50kgs/month | Shanghai Rlavie Technology Co ltd | ||
 |
2020-01-10 | ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE
34127-22-5
|
$1.00 | 1KG | 98% HPLC | 10 tons/month | Career Henan Chemical Co |
-
- Ethyl 3,6-dichloropyridazine-4-carboxylate
34127-22-5
- $1.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- 3,6-Dichloropyridazine-4-carboxylic acid ethyl ester
34127-22-5
- 98%minHPLC
- Shanghai Rlavie Technology Co ltd
-
- ETHYL 3,6-DICHLOROPYRIDAZINE-4-CARBOXYLATE
34127-22-5
- $1.00
- 98% HPLC
- Career Henan Chemical Co
