3,6-Dichloro-4-methylpyridazine
- CAS No.
- 19064-64-3
- Chemical Name:
- 3,6-Dichloro-4-methylpyridazine
- Synonyms
- SW-104;SWF-104;BUTTPARK 47\04-25;3,6-Dichloro-4-Methy;Risdiplam Impurity 11;3,6-Dichloro-4-Methyl-pyr...;3,6-Dichloro-5-methylpyridazine;4-METHYL-3,6-DICHLOROPYRIDAZINE;3,6-DICHLORO-4-METHYLPYRIDAZINE;3,4-DICHLORO-4-METHYLPYRIDAZINE
- CBNumber:
- CB0148072
- Molecular Formula:
- C5H4Cl2N2
- Molecular Weight:
- 163
- MDL Number:
- MFCD00006465
- MOL File:
- 19064-64-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 86-88 °C (lit.) |
|---|---|
| Boiling point | 149-151 °C/21 mmHg (lit.) |
| Density | 1.5462 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| Flash point | 149-151°C/21mm |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | -0.56±0.10(Predicted) |
| form | Crystalline Powder |
| color | Brown |
| BRN | 119573 |
| InChI | InChI=1S/C5H4Cl2N2/c1-3-2-4(6)8-9-5(3)7/h2H,1H3 |
| InChIKey | ROYHWGZNGMXQEU-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NN=C(Cl)C=C1C |
| CAS DataBase Reference | 19064-64-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyridazine, 3,6-dichloro-4-methyl-(19064-64-3) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-37/39-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339980 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
3,6-Dichloro-4-methylpyridazine price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 297747 | 3,6-Dichloro-4-methylpyridazine 97% | 19064-64-3 | 1g | $49.9 | 2023-06-20 | Buy |
| TCI Chemical | D4206 | 3,6-Dichloro-4-methylpyridazine >98.0%(GC) | 19064-64-3 | 1g | $30 | 2026-04-30 | Buy |
| TCI Chemical | D4206 | 3,6-Dichloro-4-methylpyridazine >98.0%(GC) | 19064-64-3 | 5g | $103 | 2026-04-30 | Buy |
| AstaTech | 60424 | 3,6-DICHLORO-4-METHYLPYRIDAZINE 97% | 19064-64-3 | 25G | $17 | 2026-04-30 | Buy |
| Biosynth | FD05940 | 3,6-Dichloro-4-methylpyridazine | 19064-64-3 | 0.025kg | $150 | 2026-06-04 | Buy |
3,6-Dichloro-4-methylpyridazine Chemical Properties, Uses, Production
Chemical Properties
Brown crystalline powder.
Uses
3,6-Dichloro-4-methylpyridazine has been used in the synthesis of 7-methyl-2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acid.
Application
3,6-Dichloro-4-methylpyridazine is mainly used as an intermediate in pesticides and pharmaceuticals.
Hazard
3,6-Dichloro-4-methylpyridazine causes skin irritation and serious eye irritation, it may cause respiratory irritation.
Synthesis
5754-18-7
19064-64-3
4-Methyl-1,2-dihydropyridazine-3,6-dione (9.48 g, 75.2 mmol) was suspended in phosphoryl chloride (70 mL, 750 mmol) under nitrogen protection and stirred at room temperature. Subsequently, the reaction mixture was heated to a mild reflux condition and maintained for 4 hours until a golden yellow homogeneous solution was formed. Upon completion of the reaction, the mixture was cooled and the excess trichlorophosphorus was removed by distillation under reduced pressure (14 mbar, 50-70°C). The resulting viscous brown oil was slowly added dropwise to an ice-cooled saturated sodium bicarbonate solution (200 mL) while stirring vigorously. The pH of the mixture was adjusted to 6 by batchwise addition of solid sodium bicarbonate, followed by extraction with ethyl acetate (2 x 60 mL). The organic phases were combined, washed with saturated sodium bicarbonate solution (30 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford 3,6-dichloro-4-methylpyridazine (11.5 g, 70.8 mmol, 94% yield) as a yellow powder. The product was recrystallized from light petroleum ether/ether and had a melting point of 87-88°C. IR spectrum (KBr, cm^-1): 3054, 1567, 1434, 1351, 1326, 1145, 1121, 914, 720. NMR hydrogen spectrum (200 MHz, CDCl3): δ 2.42 (3H, d, J = 1.0 Hz), 7.41 ( 1H, q, J = 0.9 Hz). NMR carbon spectrum (50 MHz, CDCl3): δ 19.2 (CH3), 130.1 (CH-5), 140.7 (C-4), 155.6 (C-6), 157.3 (C-3). Low resolution mass spectrum (EI): m/z 162 ([M+]). Calculated elemental analysis (C5H4Cl2N2): C, 36.84; H, 2.47; N, 17.19. Measured values: C, 36.93; H, 2.57; N, 17.48.
References
[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 5, p. 1644 - 1658
[2] Journal of the American Chemical Society, 1954, vol. 76, p. 2201
[3] Pharmaceutical Bulletin, 1957, vol. 5, p. 587,588
[4] Helvetica Chimica Acta, 1954, vol. 37, p. 121,131
[5] Journal of the American Chemical Society, 1954, vol. 76, p. 4454,4457
3,6-Dichloro-4-methylpyridazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| Xi'an Yutebang New Material Technology Co., Ltd. | 029-84536388 19991842844 | ella@yutbon.com | China | 155 | 58 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing dtftchem Technology Co., Ltd. | 010-60275820 13031183356 | elainezt@sina.com | China | 1386 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Latest Price from 3,6-Dichloro-4-methylpyridazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 3,6-Dichloro-4-methylpyridazine
19064-64-3
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-05-28 | 3,6-Dichloro-4-methylpyridazine
19064-64-3
|
$10.70 | 10KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | 3,6-Dichloro-4-methylpyridazine
19064-64-3
|
$19.00 | 100ASSAYS | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 3,6-Dichloro-4-methylpyridazine
19064-64-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 3,6-Dichloro-4-methylpyridazine
19064-64-3
- $10.70
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 3,6-Dichloro-4-methylpyridazine
19064-64-3
- $19.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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