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ChemicalBook >> CAS DataBase List >>Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)-

Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)-

Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- Structure
Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- structure
CAS No.
2062661-53-2
Chemical Name:
Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)-
Synonyms
TOVINONTRINE;IMR-687;Tovinontrine( IMR-687);Tovinontrine, 10 mM in DMSO;6-[(3S.4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-(tetrahydro-2H-pyran-4-yl)imidazo[1,5-a]pyrazin-8(7H)-one;Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)-
CBNumber:
CB48375586
Molecular Formula:
C21H26N6O2
Molecular Weight:
394.47
MDL Number:
MOL File:
2062661-53-2.mol
MSDS File:
SDS
Last updated:2026-08-26 06:30:16
Request For Quotation

Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- Properties

Density 1.45±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka 12.32±0.40(Predicted)
form Solid
color White to off-white
FDA UNII W248Y1AKOR

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth MHD66153 Tovinontrine 2062661-53-2 10mg $1009 2026-06-04 Buy
Biosynth MHD66153 Tovinontrine 2062661-53-2 25mg $1645.25 2026-06-04 Buy
Biosynth MHD66153 Tovinontrine 2062661-53-2 50mg $2632.5 2026-06-04 Buy
ChemScene CS-0119133 Tovinontrine 99.83% 2062661-53-2 5mg $347 2026-06-04 Buy
ChemScene CS-0119133 Tovinontrine 99.83% 2062661-53-2 10mg $498 2026-06-04 Buy
Product number Packaging Price Buy
MHD66153 10mg $1009 Buy
MHD66153 25mg $1645.25 Buy
MHD66153 50mg $2632.5 Buy
CS-0119133 5mg $347 Buy
CS-0119133 10mg $498 Buy

Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- Chemical Properties,Uses,Production

Uses

Tovinontrine (IMR-687) is a highly potent and selective phosphodiesterase-9 (PDE9) inhibitor specifically for the treatment of sickle cell disease. IC50s are 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively[1].

in vivo

IMR-687 (30 mg/kg/day; after 30 days of treatment) shows a greater than 3-fold in the percent of HbF+ F-cells (8.4% in vehicle treated and 27.3% in IMR-687 treated) and a corresponding 2-fold decrease in sickled red blood cells (56.3% in vehicle treated and 24.4% in IMR-687 treated)[1].

Animal Model:HbSS-Townes mice on a 129/B6 background (10-12 weeks old) [1]
Dosage:30 mg/kg
Administration:Dosed daily by gavage for 30 days
Result:Resulted in fetal hemoglobin (HbF) induction, reduced hemolysis and reduced reticulocytosis.

IC 50

PDE9A1: 8.19 nM (); PDE9A2: 9.99 nM (); PDE1A3: 88.4 nM (); PDE1B: 8.48 nM (); PDE1C: 12.2 nM (); PDE5A2: 81.9 nM ()

References

[1] James G McArthur, et al. A novel, highly potent and selective phosphodiesterase-9 inhibitor for the treatment of sickle cell disease. Haematologica. 2020 Mar;105(3):623-631. DOI:10.3324/haematol.2018.213462

Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 sales@sun-shinechem.com China 1197 64
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Wuhan Sun-shine Bio-technology Corporation Limited +86-027-6552-2453 sales@sun-shinechem.com China 725 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Jining Hengqu Biotechnology Co., Ltd. 18118824509 574487903@qq.com China 2195 58
Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd. 15990591583 China 6129 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Supplier Advantage
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 64
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Wuhan Sun-shine Bio-technology Corporation Limited 58
TargetMol Chemicals Inc. 58
Jining Hengqu Biotechnology Co., Ltd. 58
Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Lastest Price from Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tovinontrine pictures 2026-08-26 Tovinontrine
2062661-53-2
 $59.00-198.00 98.80% 10g TargetMol Chemicals Inc.
  • Tovinontrine pictures
  • Tovinontrine
    2062661-53-2
  • $59.00-198.00
  • 98.80%
  • TargetMol Chemicals Inc.

Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- Spectrum

Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)-(2062661-53-2)1HNMR

2062661-53-2(Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)-)Related Search:

Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- Ro 20-1724 Bay 60-7550 Apremilast 8-(4-Chlorophenylthio)-adenosine 3':5'-cyclic monophosphate sodium salt
W-7 Hydrochloride

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Imidazo[1,5-a]pyrazin-8(7H)-one, 6-[(3S,4S)-4-methyl-1-(2-pyrimidinylmethyl)-3-pyrrolidinyl]-3-(tetrahydro-2H-pyran-4-yl)- IMR-687 6-[(3S.4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-(tetrahydro-2H-pyran-4-yl)imidazo[1,5-a]pyrazin-8(7H)-one Tovinontrine( IMR-687) Tovinontrine, 10 mM in DMSO TOVINONTRINE 2062661-53-2