ChemicalBook >> CAS DataBase List >>7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE structure

CAS No.: 105544-36-3

Chemical Name:: 7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE

Synonyms: 7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2-ONE;7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE;:1H-Pyrido[2,3-b][1,4]oxazin-2(3H)-one,7-broMo;7-broMo-1H,2H,3H-pyrido[2,3-b][1,4]oxazin-2-one;6-bromo-1,2-dihydropyrido[2,3-b][1,4]oxazin-3-one;7-Bromo-1H-pyrrolo [2,3-B] [1,4] oxazine-2 (3H) - one

CBNumber:: CB4839961

Molecular Formula:: C7H5BrN2O2

Molecular Weight:: 229.03

MDL Number:: MFCD01648627

MOL File:: 105544-36-3.mol

MSDS File:: SDS

Last updated:2026-05-28 03:49:11

Product description	Number	Pack Size	Price
7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one Aldrich	ADE001263	1g	$870
7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one	FB154346	0.25g	$150
7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one	FB154346	0.1g	$150
7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one	FB154346	0.5g	$166.38
7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one	FB154346	1g	$249.56
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7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE Properties

Melting point	247-251 °C(Solv: ethanol (64-17-5))
Boiling point	398.8±42.0 °C(Predicted)
Density	1.772±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
pka	10.67±0.20(Predicted)
form	solid
Appearance	Light yellow to brown Solid
InChI	InChI=1S/C7H5BrN2O2/c8-4-1-5-7(9-2-4)12-3-6(11)10-5/h1-2H,3H2,(H,10,11)
InChIKey	UTPFXZJAASMEDW-UHFFFAOYSA-N
SMILES	O1CC(=O)NC2=CC(Br)=CN=C12
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
Hazard Codes	Xn
Risk Statements	22
WGK Germany	3
HazardClass	IRRITANT
Storage Class	11 - Combustible Solids

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE price More Price(45)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	ADE001263	7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one Aldrich	105544-36-3	1g	$870	2026-04-30	Buy
Biosynth	FB154346	7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one	105544-36-3	0.25g	$150	2026-06-04	Buy
Biosynth	FB154346	7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one	105544-36-3	0.1g	$150	2026-06-04	Buy
Biosynth	FB154346	7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one	105544-36-3	0.5g	$166.38	2026-06-04	Buy
Biosynth	FB154346	7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one	105544-36-3	1g	$249.56	2026-06-04	Buy

Product number	Packaging	Price	Buy
ADE001263	1g	$870	Buy
FB154346	0.25g	$150	Buy
FB154346	0.1g	$150	Buy
FB154346	0.5g	$166.38	Buy
FB154346	1g	$249.56	Buy

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE Chemical Properties,Uses,Production

Uses

7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one is an important chemical reagent that can be used to prepare heteroaryl compounds. The synthetic product can effectively inhibit necrosis and thus finds application in the treatment of diseases and conditions related to the necrosis pathway, including, for example, inflammation, tumors, metabolic diseases, and neurodegenerative diseases such as cerebral ischemia and stroke.

Synthesis

7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one is prepared by reacting 6-bromo-1H-pyrrolo[3,2-b]pyridine with pyridine and cyclohexyl carbonochloridate in anhydrous THF solution. The specific reaction process is as follows: To a solution of 6-bromo-1H-pyrrolo[3,2-b]pyridine (97 mg, 0.5 mmol) in anhydrous THF (5 mL) was added slowly pyridine (120 mg, 1.5 mmol) followed by cyclohexyl carbonochloridate (162 mg, 1 mmol) in THF (2 mL). The mixture was stirred at room temperature for 3 h. The reaction was quenched by the addition of saturated NaCl solution (20 mL). The aqueous phase was extracted with EtOAc (3×) and the combined organic layers were combined, dried and concentrated. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 5/1) to give 7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one as a colorless oily liquid (120 mg, 75%).1H NMR (400 MHz, DMSO-d6) d 8.58 (s, 2H), 7.84 (d, J = 2.4 Hz, 1H), 8.77 (d, J = 3.6 Hz, 1H), 5.13-5.00 (m, 1H), 2.13-1.97 (m, 2H), 1.91-1.75 (m, 2H), 1.72- 1.33 (m, 6H).

References

[1] Patent: US2007/191603, 2007, A1. Location in patent: Page/Page column 37
[2] Zeitschrift fuer Chemie (Stuttgart, Germany), 1986, vol. 26, # 3, p. 99
[3] Patent: WO2007/77961, 2007, A2. Location in patent: Page/Page column 358
[4] Synthetic Communications, 2013, vol. 43, # 24, p. 3315 - 3321

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE Preparation Products And Raw materials

Raw materials

5-Bromo-3-nitro-pyridin-2-yloxy)-acetic acid ethyl ester METHYL 2-((5-BROMO-3-NITROPYRIDIN-2-YL)OXY)ACETATE Methanol Sodium carbonate Dichloromethane

Preparation Products

7-Bromo-1-methyl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one 2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazine-7-carbaldehyde

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE Suppliers

Global( 123)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
Fuxin Pharmaceutical	+86-021-021-50872116	contact@fuxinpharm.com	China	9976	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49860	58
Changzhou AniKare Pharmatech Co., Ltd.	+86-0519-8359-8696	sales@anikare.com	China	9993	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +86-15355479329	market18@leapchem.com	China	43303	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501	product@acmec-e.com	China	33301	58
Aladdin Scientific		tp@aladdinsci.com	United States	54746	58
Suzhou ARTK Medchem Co., Ltd.	+86-18168183658	sales1@artkmedchem.com	China	39007	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Fuxin Pharmaceutical	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
GIHI CHEMICALS CO.,LIMITED	58
Changzhou AniKare Pharmatech Co., Ltd.	58
HANGZHOU LEAP CHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
Suzhou ARTK Medchem Co., Ltd.	58

View Lastest Price from 7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-12-04	7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE 105544-36-3			98%	100kg	Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
	2020-01-09	7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE 105544-36-3	$9.80	1g	≥99%	100kg	Career Henan Chemical Co

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE
105544-36-3
98%
Huida Pharmaceutical Technology (Shanghai) Co., Ltd.

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE
105544-36-3
$9.80
≥99%
Career Henan Chemical Co

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE Spectrum

7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE(105544-36-3)¹HNMR

105544-36-3(7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE)Related Search:

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3-HYDROXY-7-BROMO 1H-INDAZOLE Methyl 7-bromo-1H-indole-2-carboxylate 7-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID 2-amino-5-bromopyridin-3-ol 7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE

5-Bromo-2-ethoxypyridine 5-Bromo-2-methoxypyridine 2-Hydroxy-5-bromopyridine 1H-Pyrido[2,3-b][1,4]oxazin-2(3H)-one(9CI) 5-BROMO-2-METHOXY-3-CYANOPYRIDINE

2-(2-aminoethoxy)pyridine 7-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 6-BROMO-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE

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7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2(3H)-ONE 7-BROMO-1H-PYRIDO[2,3-B][1,4]OXAZIN-2-ONE 7-broMo-1H,2H,3H-pyrido[2,3-b][1,4]oxazin-2-one :1H-Pyrido[2,3-b][1,4]oxazin-2(3H)-one,7-broMo 6-bromo-1,2-dihydropyrido[2,3-b][1,4]oxazin-3-one 7-Bromo-1H-pyrrolo [2,3-B] [1,4] oxazine-2 (3H) - one 105544-36-3 C7H5BrN2O2 105544363