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ChemicalBook >> CAS DataBase List >>(4R)-4-Methyl-2-oxazolidinone

(4R)-4-Methyl-2-oxazolidinone

(4R)-4-Methyl-2-oxazolidinone Structure
(4R)-4-Methyl-2-oxazolidinone structure
CAS No.
4042-43-7
Chemical Name:
(4R)-4-Methyl-2-oxazolidinone
Synonyms
(4R)-4-Methyl-2-oxazolidinone;(R)-4-methyl-2-azolealkaneone;2-Oxazolidinone,4-methyl-,(4S)-;2-Oxazolidinone, 4-methyl-, (4R)-;(4R)-4-Methyl-2-oxazolidinone4042-43-7;Benzenepropanoicacid,6-chloro-β-oxo-,methylester
CBNumber:
CB4853602
Molecular Formula:
C4H7NO2
Molecular Weight:
101.1
MDL Number:
MOL File:
4042-43-7.mol
MSDS File:
SDS
Last updated:2026-05-28 01:16:12
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(4R)-4-Methyl-2-oxazolidinone Properties

Melting point 45.9 °C
Boiling point 302.6±9.0 °C(Predicted)
Density 1.095±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 12.84±0.40(Predicted)
Appearance White to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H317-H319
Precautionary statements  P280-P305+P351+P338
HS Code  2934999090

(4R)-4-Methyl-2-oxazolidinone price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR938550 (R)-4-Methyloxazolidin-2-one 97% 4042-43-7 250mg $29 2026-06-04 Buy
Apolloscientific OR938550 (R)-4-Methyloxazolidin-2-one 97% 4042-43-7 1g $36 2026-06-04 Buy
Apolloscientific OR938550 (R)-4-Methyloxazolidin-2-one 97% 4042-43-7 5g $112 2026-06-04 Buy
aablocks AA0072UK (R)-4-Methyloxazolidin-2-one 97% 4042-43-7 250mg $19 2026-05-28 Buy
aablocks AA0072UK (R)-4-Methyloxazolidin-2-one 98% 4042-43-7 1g $24 2026-05-28 Buy
Product number Packaging Price Buy
OR938550 250mg $29 Buy
OR938550 1g $36 Buy
OR938550 5g $112 Buy
AA0072UK 250mg $19 Buy
AA0072UK 1g $24 Buy

(4R)-4-Methyl-2-oxazolidinone Chemical Properties,Uses,Production

Synthesis

PHOSGENE

75-44-5

(R)-(-)-2-Amino-1-propanol

35320-23-1

(4R)-4-Methyl-2-oxazolidinone

4042-43-7

D-alaninol (8.65 g, 0.12 mmol) was dissolved in a mixed solvent of toluene and KOH aqueous solution (124 mL, 12.5% aqueous solution, 0.28 mmol) at 0 °C. Phosgene (72.7 mL, 20% toluene solution, 0.14 mmol) was added slowly dropwise, and the dropwise acceleration was controlled to maintain the internal temperature of the reaction system below 5 °C. After the dropwise addition, the reaction was continued to be stirred at 0 °C for 40 min. After completion of the reaction, the reaction mixture was concentrated to dryness under reduced pressure. The crude product was dissolved with industrial methanol, filtered to remove insoluble matter, and the filtrate was concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel fast column chromatography (eluent gradient: 40-100% cyclohexane solution of ethyl acetate), and 10.4 g (90% yield) of (R)-4-methyl-2-oxazolidinone was finally obtained as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 6.00 (broad single peak, 1H), 4.50 (triple peak, J=6.5 Hz, 1H), 4.07-3.97 (multiple peaks, 1H), 3.95 (double dichotomous peaks, J=7.8,6.2 Hz, 1H), and 1.30 (dichotomous peak, J=6.1 Hz, 3H).

References

[1] Patent: WO2017/1645, 2017, A1. Location in patent: Page/Page column 78; 79
[2] Patent: US2017/2022, 2017, A1. Location in patent: Paragraph 0185-0186

(4R)-4-Methyl-2-oxazolidinone Preparation Products And Raw materials

Raw materials

Phosgene (R)-(-)-2-Amino-1-propanol Triphosgene Potassium hydroxide Toluene

Preparation Products

(4R)-4-Methyl-2-oxazolidinone Suppliers

Global( 55)Suppliers
Supplier Tel Email Country ProdList Advantage
Shijizhuang Zhoukun Pharmaceutical Technology Co., LTD 0311-83784138 18633934202 zhoukunpharma@163.com China 2420 58
Nanjing Vital Chemical Co., Ltd. Please Send Email 18652950785 chemweiao@163.com China 4368 65
Doly Chemical CO.,LTD. 021-34716221 15800796336 sales@dolypharm.com China 294 55
Shanghai Apichemical CO.,LTD 021-51370612; info@apichemical.com China 242 60
Shanghai Leto Pharmatech Co.,Ltd. 86-021-5821 5861; 18016401466 sales@letopharm.com China 235 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Zhengzhou Guancheng Laboratory equipment Sales 0371-88888888 qq272369594;2159423853qq 2723695949@qq.com China 4991 50
DebyeTec.com Inc. 18086626237 18086626237 2693528373@qq.com China 2937 56
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Hangzhou Molcore Biopharmatech Co.,Ltd 400-711-5280 86-571-81025280 sales@molcore.com China 9957 58
Supplier Advantage
Shijizhuang Zhoukun Pharmaceutical Technology Co., LTD 58
Nanjing Vital Chemical Co., Ltd. 65
Doly Chemical CO.,LTD. 55
Shanghai Apichemical CO.,LTD 60
Shanghai Leto Pharmatech Co.,Ltd. 58
Bide Pharmatech Ltd. 60
Zhengzhou Guancheng Laboratory equipment Sales 50
DebyeTec.com Inc. 56
Amadis Chemical Company Limited 58
Hangzhou Molcore Biopharmatech Co.,Ltd 58

View Lastest Price from (4R)-4-Methyl-2-oxazolidinone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(4R)-4-Methyl-2-oxazolidinone pictures 2026-08-07 (4R)-4-Methyl-2-oxazolidinone
4042-43-7
 $2.00-3.00 1KG 99% 200000KG Shaanxi Dideu Medichem Co. Ltd

(4R)-4-Methyl-2-oxazolidinone Spectrum

(4R)-4-Methyl-2-oxazolidinone(4042-43-7)1HNMR

4042-43-7((4R)-4-Methyl-2-oxazolidinone)Related Search:

(R)-(-)-3-Propionyl-4-isopropyl-2-oxazolidinone (R)-4-Benzyl-2-oxazolidinone (N-Chloroacetyl)-(4S)-benzyl-2-oxazolidinone (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone (4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone
(R)-(-)-4-Phenyl-2-oxazolidinone (R)-(+)-4-Isopropyl-2-oxazolidinone (-)-CHIRACAMPHOX Z-D-Phenylalanine N-carboxyanhydride N-Acetyl-(4R)-isopropyl 2-oxazolidinone
N-Propionyl-(4S,5R)-4-methyl- 5-phenyl-2-oxazolidinone N-Acetyl-(4S,5R)-4-methyl 5-phenyl-2-oxazolidinone (N-Acetyl)-(4R)-benzyl-2-oxazolidinone (R)-(-)-5,5-Dimethyl-4-phenyl-2-oxazolidinone (R)-(+)-4-Benzyl-5,5-dimethyl-2-oxazolidinone
N-Crotonyl-(4R,5S)-4-methyl 5-phenyl-2-oxazolidinone 3-Bromo-4,4-dimethyl-2-oxazolidinone N-(Diethylphosphonoacetyl) (4R)-benzyl-2-oxazolidinone

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(4R)-4-Methyl-2-oxazolidinone (4R)-4-Methyl-2-oxazolidinone4042-43-7 2-Oxazolidinone, 4-methyl-, (4R)- 2-Oxazolidinone,4-methyl-,(4S)- Benzenepropanoicacid,6-chloro-β-oxo-,methylester (R)-4-methyl-2-azolealkaneone 4042-43-7