2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]-
![2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]- Structure](CAS/20210305/GIF/1432494-65-9.gif)
- CAS No.
- 1432494-65-9
- Chemical Name:
- 2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]-
- Synonyms
- 2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]-
- CBNumber:
- CB48683168
- Molecular Formula:
- C60H120N4O6
- Molecular Weight:
- 993.62
- MDL Number:
- MOL File:
- 1432494-65-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 1003.2±65.0 °C(Predicted) |
|---|---|
| Density | 0.963±0.06 g/cm3(Predicted) |
| solubility | Chloroform: soluble; Ethanol: soluble; Methanol: soluble |
| form | Liquid |
| pka | 12.87±0.60(Predicted) |
| color | Colorless to light yellow |
| InChIKey | ZISVTYVLWSZJAL-UHFFFAOYSA-N |
| SMILES | N1C(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C(=O)NC(CCCCN(CC(O)CCCCCCCCCC)CC(O)CCCCCCCCCC)C1=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 36700 | cKK-E12 ≥95% | 1432494-65-9 | 5mg | $270 | 2026-04-30 | Buy |
| Cayman Chemical | 36700 | cKK-E12 ≥95% | 1432494-65-9 | 10mg | $432 | 2026-04-30 | Buy |
| Cayman Chemical | 36700 | cKK-E12 ≥95% | 1432494-65-9 | 25mg | $876 | 2026-04-30 | Buy |
| Cayman Chemical | 36700 | cKK-E12 ≥95% | 1432494-65-9 | 50mg | $1348 | 2026-04-30 | Buy |
| ChemScene | CS-0149249 | CKK-E12 98.0% | 1432494-65-9 | 5mg | $271 | 2026-06-04 | Buy |
2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]- Chemical Properties, Uses, Production
Description
CKK-E12 is an ionizable lipid. It is useful for Development of Lipidoid Nanoparticles for siRNA, mRNA, and vaccine delivery.
Uses
CKK-E12 is a ionizable lipid in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based research. CKK-E12 is highly selective toward liver parenchymal cell in vivo,
in vivo
CKK-E12 delivers siRNA in mice, rats and primates (ED50 is 0.002, 0.01 and 0.3 mg/kg, respectively)[1].
References
[1] Dong Y, Love KT, Dorkin JR, et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates [published correction appears in Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5753].Proc Natl Acad Sci U S A. 2014;111(11):3955-3960. DOI:10.1073/pnas.1322937111
[2] Oberli MA, Reichmuth AM, Dorkin JR, et al. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017;17(3):1326-1335. DOI:10.1021/acs.nanolett.6b03329
[3] Hatit MZC, et al. Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles. Nat Nanotechnol. 2022 Mar;17(3):310-318. doi: 10.1038/s41565-021-01030-y. Epub 2022 Feb 7. DOI:10.1038/s41565-021-01030-y
2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
2,5-Piperazinedione, 3,6-bis[4-[bis(2-hydroxydodecyl)amino]butyl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shochem(Shanghai)Co.,Ltd | +86-021-50800795 13816874662 | info@shochem.com | China | 500 | 58 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 7983 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Shochem(Shanghai)Co.,Ltd | +86-021-51783479 13816874662 | info@shochem.com | China | 300 | 58 |
| Shanghai Ruipu Medical Technology Co., Ltd | 15895968936 | 1018762393@qq.com | China | 9992 | 58 |
| Zhengzhou convergence chemical co., LTD | 037155153829 18003835034 | 3897192574@qq.com | China | 9982 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Tianjin Yankai Scientific Co. Ltd. | 18500985499 | yankaisale@qq.com | China | 496 | 58 |
