tolonidine
- CAS No.
- 4201-22-3
- Chemical Name:
- tolonidine
- Synonyms
- ST-375;tolonidine;N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine;1H-Imidazol-2-amine, N-(2-chloro-4-methylphenyl)-4,5-dihydro-
- CBNumber:
- CB4875314
- Molecular Formula:
- C10H12ClN3
- Molecular Weight:
- 209.68
- MDL Number:
- MOL File:
- 4201-22-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 148-150° |
|---|---|
| Boiling point | 314.0±52.0 °C(Predicted) |
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 9.41(at 25℃) |
| form | Solid |
| color | White to off-white |
| FDA UNII | I4O795Q03O |
| ATC code | C02AC04 |
tolonidine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | EAA20122 | N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine | 4201-22-3 | 50mg | $394 | 2026-06-04 | Buy |
| Biosynth | EAA20122 | N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine | 4201-22-3 | 0.5g | $1180 | 2026-06-04 | Buy |
| ChemScene | CS-0013841 | Tolonidine 99.59% | 4201-22-3 | 5mg | $65 | 2026-06-04 | Buy |
| ChemScene | CS-0013841 | Tolonidine 99.59% | 4201-22-3 | 10mg | $108 | 2026-06-04 | Buy |
| ChemScene | CS-0013841 | Tolonidine 99.59% | 4201-22-3 | 25mg | $211 | 2026-06-04 | Buy |
tolonidine Chemical Properties, Uses, Production
Originator
Euctan,Essex,Switz.,1978
Definition
ChEBI: Tolonidine is a substituted aniline.
Manufacturing Process
43 g of the thiourea compound (melting point 124°C) obtained in known
fashion from 2-chloro-4-methylaniline and ammonium thiocyanate and 20 cc
of methyl iodide were dissolved in 200 cc of methanol, and the solution was
refluxed for two hours.1 Thereafter, the solvent was evaporated in vacuo,
leaving 73.2 g of the isothiouronium hydroiodide of the formula as a residue.
This isothiouronium salt was admixed with 20 cc of ethylenediamine, and the
mixture was heated for about 30 minutes at 150°C to 160°C, accompanied by
stirring; methyl mercaptan escaped during that time. Subsequently, the
reaction mixture was taken up in hot dilute acetic acid, and the resulting
solution was made alkaline with 2 N sodium hydroxide. A precipitate formed,
which was separated by vacuum filtration, washed with water and dried. It
was identified to be 2-(2'-chloro-4'-methylphenyl)-amino-1,3-
diazacyclopentene-(2) having a melting point of 142°C to 145°C. The yield
was 10.2 g.
The nitrate of the base, obtained by acidifying a solution of the free base with
nitric acid, had a melting point of 162°C to 164°C and was soluble in water
and methanol.
Therapeutic Function
Antihypertensive
tolonidine Preparation Products And Raw materials
Raw materials
Preparation Products
tolonidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
View Latest Price from tolonidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | Tolonidine
4201-22-3
|
$30.00 | 10g | TargetMol Chemicals Inc. |
-
- Tolonidine
4201-22-3
- $30.00
- TargetMol Chemicals Inc.
