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톨로니딘

톨로니딘 구조식 이미지

카스 번호:: 4201-22-3

한글명:: 톨로니딘

동의어(한글):: 톨로니딘

상품명:: tolonidine

동의어(영문):: ST-375;tolonidine;N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine;1H-Imidazol-2-amine, N-(2-chloro-4-methylphenyl)-4,5-dihydro-

CBNumber:: CB4875314

분자식:: C10H12ClN3

포뮬러 무게:: 209.68

MOL 파일:: 4201-22-3.mol

속성

안전

용도

공급 업체 22

톨로니딘 속성

녹는점: 148-150°

끓는 점: 314.0±52.0 °C(Predicted)

밀도: 1.31±0.1 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMSO에 용해됨

산도 계수 (pKa): 9.41(at 25℃)

물리적 상태: Solid

색상: White to off-white

안전

톨로니딘 C화학적 특성, 용도, 생산

Originator

Euctan,Essex,Switz.,1978

Manufacturing Process

43 g of the thiourea compound (melting point 124°C) obtained in known fashion from 2-chloro-4-methylaniline and ammonium thiocyanate and 20 cc of methyl iodide were dissolved in 200 cc of methanol, and the solution was refluxed for two hours.1 Thereafter, the solvent was evaporated in vacuo, leaving 73.2 g of the isothiouronium hydroiodide of the formula as a residue. This isothiouronium salt was admixed with 20 cc of ethylenediamine, and the mixture was heated for about 30 minutes at 150°C to 160°C, accompanied by stirring; methyl mercaptan escaped during that time. Subsequently, the reaction mixture was taken up in hot dilute acetic acid, and the resulting solution was made alkaline with 2 N sodium hydroxide. A precipitate formed, which was separated by vacuum filtration, washed with water and dried. It was identified to be 2-(2'-chloro-4'-methylphenyl)-amino-1,3- diazacyclopentene-(2) having a melting point of 142°C to 145°C. The yield was 10.2 g.
The nitrate of the base, obtained by acidifying a solution of the free base with nitric acid, had a melting point of 162°C to 164°C and was soluble in water and methanol.

Therapeutic Function

Antihypertensive

톨로니딘 준비 용품 및 원자재

원자재

에틸렌디아민 질산 2-Chloro-4-methylaniline 요오드 메탄 싸이오사이안산암모늄(로단암몬)

준비 용품

톨로니딘 공급 업체

글로벌( 22)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Beijing Solarbio Science & Tecnology Co., Ltd.	17801761073 18101056239	3193328036@qq.com	China	28150	68
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11123	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	27626	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58
TargetMol Chemicals Inc.	13564774135	marketing@targetmol.com	United States	19950	58