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ChemicalBook >> CAS DataBase List >>1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-

1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-

1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)- Structure
1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)- structure
CAS No.
2403733-82-2
Chemical Name:
1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-
Synonyms
8-methoxy-6-(7-(2-morpholinoethoxy)imidazo[1,2-a]pyridin-3-yl)-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1(2H)-one;1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-;8-methoxy-6-{7-[2-(morpholin-4-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1-one - [AC78220]
CBNumber:
CB49280454
Molecular Formula:
C25H27F3N4O4
Molecular Weight:
504.5
MDL Number:
MOL File:
2403733-82-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-20 20:20:01
Request For Quotation

1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)- Properties

Density 1.40±0.1 g/cm3(Predicted)
pka 5.87±0.10(Predicted)
form Solid
color White to off-white
FDA UNII UA6B2TI4MO

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0628487 GLPG3970 99.70% 2403733-82-2 5mg $217 2026-06-04 Buy
ChemScene CS-0628487 GLPG3970 99.70% 2403733-82-2 10mg $325 2026-06-04 Buy
ChemScene CS-0628487 GLPG3970 99.70% 2403733-82-2 25mg $520 2026-06-04 Buy
ChemScene CS-0628487 GLPG3970 99.70% 2403733-82-2 50mg $780 2026-06-04 Buy
ChemScene CS-0628487 GLPG3970 99.70% 2403733-82-2 100mg $1132 2026-06-04 Buy
Product number Packaging Price Buy
CS-0628487 5mg $217 Buy
CS-0628487 10mg $325 Buy
CS-0628487 25mg $520 Buy
CS-0628487 50mg $780 Buy
CS-0628487 100mg $1132 Buy

1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)- Chemical Properties, Uses, Production

Uses

GLPG3970 (compound 88) is a first-in-class SIK2/SIK3 inhibitor. GLPG3970 can be used for the research of inflammation and autoimmune disease[1].

in vivo

GLPG3970 (10 mg/kg; oral administration; twice daily for 5 consecutive days) decreases the ear thickness of murine models of psoriatic-like epidermal hyperplasia induced by intradermal injections of IL-23[1]. GLPG3970 (60 mg/kg; oral administration; twice daily until mice are sacrificed) shows better clinical manifestations compared to vehicle groups in murine collagen-antibody induced arthritis model (CAIA)[1]. GLPG3970 (30 mg/kg; oral administration; twice daily for 7 consecutive days) reduces disease activity index ompared to vehicle groups in mice T cell transfer model[1].

References

[1] DESROY N, et al. NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES. WO/2019/238424. 2019.

1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)- Suppliers

Global Suppliers ( 23)
Supplier Tel Email Country ProdList Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2994 55
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 964 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9867 58
Hubei wei shi reagent group ltd., company 027-59102966 18717199209 2853877583@qq.com China 2896 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
Shanghai Huici Pharmaceutical Technology Co., LTD 133-31922809 19372841038 lixing@pharmahuici.com China 853 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Supplier Advantage
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai Beckham Medical Technology Co., Ltd 55
TargetMol Chemicals Inc. 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Hubei wei shi reagent group ltd., company 58
Bide Pharmatech Ltd. 58
Shanghai Huici Pharmaceutical Technology Co., LTD 58
TargetMol Chemicals Inc. 58

View Latest Price from 1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GLPG3970 pictures 2026-08-20 GLPG3970
2403733-82-2
 $60.00-198.00 99.63% 10g TargetMol Chemicals Inc.
  • GLPG3970 pictures
  • GLPG3970
    2403733-82-2
  • $60.00-198.00
  • 99.63%
  • TargetMol Chemicals Inc.

1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)- Spectrum

1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-(2403733-82-2)1HNMR

2403733-82-2 (1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)-) Related Search:

1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)- 1(2H)-Isoquinolinone, 6-(7-fluoroimidazo[1,2-a]pyridin-3-yl)-3,4-dihydro-8-methoxy-2-(2,2,2-trifluoroethyl)- RSS0680 YKL-05-099 YKL-06-062
SIK3 Human Pre-designed siRNA Set A

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1(2H)-Isoquinolinone, 3,4-dihydro-8-methoxy-6-[7-[2-(4-morpholinyl)ethoxy]imidazo[1,2-a]pyridin-3-yl]-2-(2,2,2-trifluoroethyl)- 8-methoxy-6-(7-(2-morpholinoethoxy)imidazo[1,2-a]pyridin-3-yl)-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1(2H)-one 8-methoxy-6-{7-[2-(morpholin-4-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-2-(2,2,2-trifluoroethyl)-3,4-dihydroisoquinolin-1-one - [AC78220] 2403733-82-2