tert-butyl 4-hydroxybenzoate
- CAS No.
- 25804-49-3
- Chemical Name:
- tert-butyl 4-hydroxybenzoate
- Synonyms
- tert-Butyl p-hydroxybenzoate;tert-butyl 4-hydroxybenzoate;1,1-Dimethylethyl 4-hydroxybenzoate;p-Hydroxybenzoic acid tert-butyl ester;4-Hydroxy-benzoic acid tert-butyl ester;4-Hydroxybenzoic acid 1,1-dimethylethyl ester;Benzoic acid, 4-hydroxy-, 1,1-diMethylethyl ester
- CBNumber:
- CB4935199
- Molecular Formula:
- C11H14O3
- Molecular Weight:
- 194.23
- MDL Number:
- MFCD09953072
- MOL File:
- 25804-49-3.mol
- MSDS File:
- SDS
| Melting point | 130-132 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4)) |
|---|---|
| Boiling point | 295.6±13.0 °C(Predicted) |
| Density | 1.107±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| pka | 8.25±0.15(Predicted) |
| color | White |
| FDA UNII | B8SS68TDWJ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2918290090 |
tert-butyl 4-hydroxybenzoate price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | ABA80449 | tert-Butyl 4-hydroxybenzoate | 25804-49-3 | 100g | $625 | 2026-06-04 | Buy |
| Biosynth | ABA80449 | tert-Butyl 4-hydroxybenzoate | 25804-49-3 | 250g | $875 | 2026-06-04 | Buy |
| Biosynth | ABA80449 | tert-Butyl 4-hydroxybenzoate | 25804-49-3 | 500g | $1125 | 2026-06-04 | Buy |
| Biosynth | ABA80449 | tert-Butyl 4-hydroxybenzoate | 25804-49-3 | 1000g | $1630 | 2026-06-04 | Buy |
| Apolloscientific | OR52549 | tert-Butyl 4-hydroxybenzoate >98% | 25804-49-3 | 5g | $21 | 2026-06-04 | Buy |
tert-butyl 4-hydroxybenzoate Chemical Properties, Uses, Production
Uses
4-Hydroxybenzoate tert-butyl ester is used in organic synthesis, biochemical research, etc.
Synthesis
75-65-0
99-96-7
25804-49-3
Using p-hydroxybenzoic acid (1.50 g, 10.86 mmol) and tert-butanol (13.34 g, 18 mmol) as raw materials, DCC (2.5 g, 12.00 mmol) was dissolved in DCM (40 mL) catalyzed by DBU (0.19 mL, 1.20 mmol), and the reaction mixture was stirred vigorously for 18 hours at room temperature. After completion of the reaction, the solvent was evaporated to dryness and the residue was dissolved in DCM (50 mL) and filtered to remove insoluble material. The filtrate was washed sequentially with saturated NaHCO3 solution (50 mL), K2CO3 solution (2 x 50 mL) and saturated NaCl solution (50 mL). The organic phase was dried with MgSO4, filtered and the solvent was evaporated to give the crude product. The crude product was purified by column chromatography (EtOAc:hexane gradient elution) to afford tert-butyl 4-hydroxybenzoate (SO2-059) (31) as a white crystalline solid (1.1 g, 55% yield).1H NMR (400 MHz, CDCl3) δ 7.89 (d, J = 8.8 Hz, 1H), 6.84 (d, J = 8.9 Hz, 1H) 5.29 (s, 1H), 1.57 (s, 9H).
References
[1] Journal of Materials Chemistry, 2007, vol. 17, # 48, p. 5097 - 5110
[2] Synthesis, 2003, # 16, p. 2479 - 2482
[3] European Journal of Medicinal Chemistry, 2015, vol. 101, p. 716 - 735
[4] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 14, p. 3645 - 3649
[5] Journal of Medicinal Chemistry, 2013, vol. 56, # 10, p. 3783 - 3805
tert-butyl 4-hydroxybenzoate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Zhengzhou HongSheng Pharmaceutical Co., Ltd. | 0371-0371-13526885213 15637198702 | hsyykjchem@163.com | China | 1854 | 58 |
| Tianjin Anhao Biological Technology Co., Ltd. | sales@ahpharmatech.com | China | 5734 | 55 | |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5855 | 50 |
| Chengdu DingDang Pharmaceutical Co., Ltd. | 028-86040038 | market@dingdangchem.com | China | 1853 | 55 |
View Latest Price from tert-butyl 4-hydroxybenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | tert-butyl 4-hydroxybenzoate
25804-49-3
|
$1.00 | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- tert-butyl 4-hydroxybenzoate
25804-49-3
- $1.00
- 99.0%
- Career Henan Chemical Co
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