3,4-dihydro-2H-1,4-benzoxazin-6-ol
- CAS No.
- 26021-57-8
- Chemical Name:
- 3,4-dihydro-2H-1,4-benzoxazin-6-ol
- Synonyms
- 3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZIN-6-OL;3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-OL;3,4-Dihyd2H-benzo[b][1,4]oxazin-6-ol;3,4-Dihydro-2H-benzo[1,4]oxazin-6-ol;2H-1,4-Benzoxazin-6-ol, 3,4-dihydro-
- CBNumber:
- CB4940667
- Molecular Formula:
- C8H9NO2
- Molecular Weight:
- 151.16
- MDL Number:
- MFCD00600394
- MOL File:
- 26021-57-8.mol
| Boiling point | 334.7±42.0 °C(Predicted) |
|---|---|
| Density | 1.241±0.06 g/cm3(Predicted) |
| vapor pressure | 0.002Pa at 20℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly, Heated, Sonicated), DMSO (Sparingly), Methanol (Slightly) |
| form | Solid |
| pka | 10.85±0.20(Predicted) |
| color | Black |
| Water Solubility | 19g/L at 20℃ |
| Stability | Hygroscopic |
| Cosmetics Ingredients Functions | HAIR DYEING |
| InChI | InChI=1S/C8H9NO2/c10-6-1-2-8-7(5-6)9-3-4-11-8/h1-2,5,9-10H,3-4H2 |
| InChIKey | HWWIVWKTKZAORO-UHFFFAOYSA-N |
| SMILES | O1C2=CC=C(O)C=C2NCC1 |
| LogP | 0.219 at 23℃ |
| FDA UNII | 77OXT3492A |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2934999090 |
| REACH Registrations | Active |
3,4-dihydro-2H-1,4-benzoxazin-6-ol price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-D679870-50MG | 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol | 26021-57-8 | 50mg | $151 | 2026-06-03 | Buy |
| TRC | TRC-D679870-10MG | 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol | 26021-57-8 | 10mg | $74 | 2026-06-03 | Buy |
| TRC | TRC-D679870-100MG | 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol | 26021-57-8 | 100mg | $185 | 2026-06-03 | Buy |
| Activate Scientific | AS43362 | 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol 95% | 26021-57-8 | 1g | $232 | 2026-06-04 | Buy |
| Activate Scientific | AS43362 | 3,4-Dihydro-2H-benzo[b][1,4]oxazin-6-ol 95% | 26021-57-8 | 5g | $864 | 2026-06-04 | Buy |
3,4-dihydro-2H-1,4-benzoxazin-6-ol Chemical Properties,Uses,Production
Flammability and Explosibility
Not classified
Synthesis
53412-38-7
26021-57-8
General procedure for the synthesis of 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-ol from 6-hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one: 6-Hydroxy-2H-benzo[b][1,4]oxazin-3(4H)-one (0.39 g, 2.35 mmol) was dissolved in tetrahydrofuran (THF) and at 0 °C 1 M borane-THF solution (7.05 mL, 7.05 mmol) was slowly added dropwise for a controlled time of 5 min. After the dropwise addition, the reaction mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, the excess borane was quenched by careful addition of methanol. Subsequently, the solvent was removed by distillation under reduced pressure and the crude product was extracted with ethyl acetate (EtOAc) to afford pure 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-ol as an oil in quantitative yield (0.34 g). The product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, DMSO-d6): δ 8.48 (s, 1H), 6.37 (d, 1H, J = 8.47 Hz), 5.96 (d, 1H, J = 2.75 Hz), 5.82 (dd, 1H, J = 8.44, 2.76 Hz), 3.97 (t, 2H, J = 4.38 Hz), 3.18 ( t, 2H, J = 4.31 Hz). Nuclear magnetic resonance carbon spectrum (13C NMR, DMSO-d6): δ 152.2, 136.6, 135.8, 116.7, 103.8, 102.0, 65.0, 47.2. electrospray high-resolution mass spectrometry (ES-HRMS) measured [M + H]+ as 152.0711, which is in accordance with the theoretically calculated value (C8H10NO2).
References
[1] Patent: WO2009/36351, 2009, A2. Location in patent: Page/Page column 21; 22/24
3,4-dihydro-2H-1,4-benzoxazin-6-ol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Luyuan Biomedical Technology Co., LTD | 13210587493 | jinanluyuan@hotmail.com | China | 439 | 58 |
| Wuxi KaiLi Biotech Co.,Ltd | 0510-80721533 13327925606 | sales@klbiotech.com | China | 134 | 58 |
| Hubei Henghua Technology Co., Ltd. | 18064208139 | 2912268575@qq.com | China | 1937 | 58 |
| Xi 'an billiton biological technology co., LTD | 029-88764766 | chen.zeshan@xatuochao.com | China | 521 | 58 |
| Lianyungang Langrun Chemical Technology Co., Ltd. | 17705136709 | 343200474@qq.com | China | 15 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| HBCChem, Inc. | +1-510-219-6317 | sales@hbcchem.com | United States | 10628 | 60 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
View Lastest Price from 3,4-dihydro-2H-1,4-benzoxazin-6-ol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 3,4-dihydro-2H-1,4-benzoxazin-6-ol
26021-57-8
|
1kg | 98% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 3,4-dihydro-2H-1,4-benzoxazin-6-ol
26021-57-8
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
26021-57-8(3,4-dihydro-2H-1,4-benzoxazin-6-ol)Related Search:
1of4
