3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone
- CAS No.
- 35773-42-3
- Chemical Name:
- 3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone
- Synonyms
- 3-(Benzo[d]oxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one;ChemBridge-5213777;EMI1 (EGFR MaMTH Inhibitor 1);3-(2-Benzoxazolyl)-7-(diethylamino)coumarin;3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone;3-(Benzoxazol-2-yl)-7-diethylamino-2H-1-benzopyran-2-one;3-(1,3-benzoxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one;2H-1-Benzopyran-2-one, 3-(2-benzoxazolyl)-7-(diethylamino)-;7-(Diethylamino)-3-(benzoxazole-2-yl)-2H-1-benzopyran-2-one;3-(Benzoxazole-2-yl)-7-(diethylamino)-2H-1-benzopyran-2-one
- CBNumber:
- CB4942287
- Molecular Formula:
- C20H18N2O3
- Molecular Weight:
- 334.37
- MDL Number:
- MOL File:
- 35773-42-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 185-186 °C(Solv: N,N-dimethylformamide (68-12-2)) |
|---|---|
| Boiling point | 551.0±60.0 °C(Predicted) |
| Density | 1.284±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 2mg/mL, clear |
| form | Solid |
| pka | 2.94±0.20(Predicted) |
| color | Light yellow to yellow |
| InChI | 1S/C20H18N2O3/c1-3-22(4-2)14-10-9-13-11-15(20(23)25-18(13)12-14)19-21-16-7-5-6-8-17(16)24-19/h5-12H,3-4H2,1-2H3 |
| InChIKey | UJOQSHCJYVRZKJ-UHFFFAOYSA-N |
| SMILES | N(CC)(CC)c1cc2[o][c](c(cc2cc1)c3nc4c([o]3)cccc4)=O |
| EPA Substance Registry System | 2H-1-Benzopyran-2-one, 3-(2-benzoxazolyl)-7-(diethylamino)- (35773-42-3) |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| WGK Germany | WGK 3 |
|---|---|
| TSCA | TSCA listed |
| Storage Class | 11 - Combustible Solids |
3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2914 | EMI1 ≥98% (HPLC) | 35773-42-3 | 5MG | $60.01 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2914 | EMI1 ≥98% (HPLC) | 35773-42-3 | 25MG | $244.8 | 2026-04-30 | Buy |
| Biosynth | KBA77342 | Emi1 (egfr mamth inhibitor 1) | 35773-42-3 | 50mg | $953 | 2026-06-04 | Buy |
| Biosynth | KBA77342 | Emi1 (egfr mamth inhibitor 1) | 35773-42-3 | 100mg | $1325 | 2026-06-04 | Buy |
| ChemScene | CS-0144250 | EMI1 99.45% | 35773-42-3 | 5mg | $76 | 2026-06-04 | Buy |
3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone Chemical Properties,Uses,Production
Uses
EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1].
Biological Activity
EMI1 (ChemBridge 5213777) is a call penetrant and potent inhibitor of EGFR signaling in EGFR L858R/T790M/C797S and ex19del/T790M/C797S triple mutants associated with drug-resistant NSCLC. Additionally, EMI1 potently depolymerized interphase microtubules, disrupts spindle formation and induced mitotic block in PC9 EGFR ex19del/T790M/C797S cells. EMI1 exhibits potent anti-proliferative activity against various cancer cell lines.
IC 50
EGFRdel19 T790M C797S; EGFRL858R/T790M/C797S
References
[1] Punit Saraon, et al. A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat Chem Biol. 2020 May;16(5):577-586. DOI:10.1038/s41589-020-0484-2
3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone Preparation Products And Raw materials
Raw materials
Preparation Products
3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9796 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Zhejiang Huida Biotech Co., LTD | 0571-89903022 18679456698 | zilong@hizyme.com | China | 8001 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | 2232176231@qq.com | China | 9997 | 58 |
