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GW4869

GW4869 Structure
GW4869 structure
CAS No.
6823-69-4
Chemical Name:
GW4869
Synonyms
GW 4869 (hydrochloride hydrate);CS-2410;GW4869(2);GW4869(1);GW4869 HCl;GW4869 2HCl;GW4869/GW-4869;GW4869 (GW69A);GW69A， GW554869A;GW4869 USP/EP/BP
CBNumber:
CB4972736
Molecular Formula:
C30H29ClN6O2
Molecular Weight:
541.05
MDL Number:
MFCD06411564
MOL File:
6823-69-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-20 17:44:43
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GW4869 Properties

Melting point >300 °C
storage temp. 2-8°C
solubility DMSO: soluble0.2mg/mL
form powder
color light yellow to yellow
InChIKey NSFKAZDTKIKLKT-LOLTXFFGSA-N
SMILES Cl.Cl.O=C(Nc1ccc(cc1)C2=NCCN2)\C=C/c3ccc(\C=C/C(=O)Nc4ccc(cc4)C5=NCCN5)cc3
UNSPSC Code 41121800
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  22-24/25
WGK Germany  3
HS Code  2933299090
Storage Class 11 - Combustible Solids

GW4869 price More Price(66)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D1692 GW4869 ≥90% (NMR) 6823-69-4 5mg $261 2026-04-30 Buy
Cayman Chemical 13127 GW 4869 (hydrochloride hydrate) ≥90% 6823-69-4 500μg $39 2026-04-30 Buy
Cayman Chemical 13127 GW 4869 (hydrochloride hydrate) ≥90% 6823-69-4 1mg $74 2026-04-30 Buy
Cayman Chemical 13127 GW 4869 (hydrochloride hydrate) ≥90% 6823-69-4 5mg $154 2026-04-30 Buy
Cayman Chemical 13127 GW 4869 (hydrochloride hydrate) ≥90% 6823-69-4 10mg $270 2026-04-30 Buy
Product number Packaging Price Buy
D1692 5mg $261 Buy
13127 500μg $39 Buy
13127 1mg $74 Buy
13127 5mg $154 Buy
13127 10mg $270 Buy

GW4869 Chemical Properties, Uses, Production

Uses

GW4869 has been used:

  • as an inhibitor of neutral sphingomyelinase and exosome biogenesis
  • to analyse the effects of arsenic trioxide (ATO) treatment for hepatoma carcinoma HCCLM3 cells on ceramide production
  • to determine the contributions of p75 neurotrophin receptor (p75NTR) and tropomyosin receptor kinase A (TrkA)- coupled pathways to nerve growth factor (NGF)-induced thermal hypersensitivity in rats

General Description

GW4869 is a commonly used pharmacological agent, which inhibits exosome generation. It blocks ceramide-mediated inward budding of multivesicular bodies (MVBs) and the release of mature exosomes from MVBs. GW4869 exhibits cytotoxicity to phosphatidylserine-expressing myeloma cells. It inhibits the secretion of IFN (interferon)-α by plasmacytoid dendritic cells(pDCs).

Biochem/physiol Actions

A cell-permeable, potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase)

in vivo

GW4869 (2.5 μg/g, i.p.) causes inhibition of exosome release blocks LPS-stimulated pro-inflammatory cytokine production and cardiac inflammation in mice. GW4869 mitigates LPS-caused myocardial dysfunction and improves survival in mice[2].
GW4869 (2.5 μg/g, i.p.) blocks the production of pro-inflammatory cytokines and cardiac inflammation in CLP mice[2].

Animal Model:10-12 weeks old Male wild-type C57BL/6 mice (Endotoxin-Challenged Mice)[2].
Dosage:2.5 μg/g.
Administration:I.P. once (1 h later, followed by an i.p. injection of LPS (2.5 μg/g, 100 μL)).
Result:Significantly decreased exosome levels by 37% in sera, compared to levels collected from control mice. At 12 h after LPS injection, the levels of circulating exosomes were increased significantly compared to PBS-controls, as evidenced by a 1.7-fold elevation in the AChE activity.
Animal Model:10-12 weeks old Male wild-type C57BL/6 mice (CLP Polymicrobial Sepsis Model)[2].
Dosage:2.5 μg/g.
Administration:I.P. once (before sham or CLP surgery).
Result:Decreased exosome concentration by 33% compared to mice injected with PBS in sham-surgery controls.
CLP-stimulated exosome release was significantly inhibited by pre-treatment of CLP mice compared to CLP mice pre-treated with PBS.

GW4869 Preparation Products And Raw materials

Raw materials

Preparation Products

GW4869 Suppliers

Global Suppliers ( 122)
Supplier Tel Email Country ProdList Advantage
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Macklin Biochemical Co.,Ltd. 15221275939 15221275939 shenlinxing@macklin.cn China 15775 55
AdooQ Bioscience CHINA 025-58849295 info@adooq.cn China 2981 60
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4865 55
Supplier Advantage
VDM Biochemicals 64
Dalian Meilun Biotech Co., Ltd. 58
MedChemexpress LLC 58
Guangzhou Isun Pharmaceutical Co., Ltd 55
AdooQ BioScience, LLC 58
Bide Pharmatech Ltd. 60
Shanghai Macklin Biochemical Co.,Ltd. 55
AdooQ Bioscience CHINA 60
Sigma-Aldrich 80
Shanghai Lollane Biological Technology Co.,Ltd. 55

View Latest Price from GW4869 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GW4869 USP/EP/BP pictures 2026-08-20 GW4869 USP/EP/BP
6823-69-4
 $1.10 1g 99.9% 100 Tons min Dideu Industries Group Limited
GW4869 pictures 2026-07-20 GW4869
6823-69-4
 $48.00-87.00 99.66% 10g TargetMol Chemicals Inc.
GW4869 pictures 2019-12-23 GW4869
6823-69-4
 $1.00 1g 99.99% 200kg Career Henan Chemical Co
  • GW4869 pictures
  • GW4869
    6823-69-4
  • $48.00-87.00
  • 99.66%
  • TargetMol Chemicals Inc.
  • GW4869 pictures
  • GW4869
    6823-69-4
  • $1.00
  • 99.99%
  • Career Henan Chemical Co

GW4869 Spectrum

GW4869(6823-69-4)1HNMR

6823-69-4 (GW4869) Related Search:

SLUPP-225 GW4869 [1,1'-Biphenyl]-4,4'-dicarboxamide,N4,N4'-bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2) 1-N,3-N,5-N-tris[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]benzene-1,3,5-tricarboxamide,hydrochloride SLUPP-417
Eflornithine hydrochloride hydrate

1of2

N-SMase Inhibitor, GW4869 - CAS 6823-69-4 - Calbiochem CS-2410 N-SMase Inhibitor 2-PropenaMide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-iMidazol-2-yl)phenyl]-, hydrochloride (1:2) 4',4''-Di-2-imidazolin-2-yl-p-benzenediacrylanilide dihydrochloride GW 4869 (hydrochloride hydrate) GW4869/GW-4869 GW4869 dihydrochloride GW4869;GW 4869 HYDROCHLORIDE HYDRATE GW4869(1) GW4869(2) GW69A， GW554869A GW4869 USP/EP/BP GW4869 2HCl p-Benzenediacrylanilide, 4′,4′′-di-2-imidazolin-2-yl-, dihydrochloride GW4869 HCl GW-4869,Inhibitor,Phospholipase,GW4869,inhibit GW4869 (GW69A) 3,3'-(1,4-Phenylene)bis(N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)acrylamide) dihydrochloride (2E,2'E)-3,3'-(1,4-phenylene)bis(N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)acrylamide) dihydrochloride 6823-69-4 C30H28N6O22HCl C30H30N6Cl2O2 API A cell-permeable, symmetrical dihydroimidazolo-amide compound that acts as a potent, specific, non-competitive inhibitor of N-SMase.