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2-(4-Bromo-benzyl)-malonic acid diethyl ester

2-(4-Bromo-benzyl)-malonic acid diethyl ester Structure
2-(4-Bromo-benzyl)-malonic acid diethyl ester structure
CAS No.
70146-78-0
Chemical Name:
2-(4-Bromo-benzyl)-malonic acid diethyl ester
Synonyms
diethyl 2-(4-broMobenzyl)Malonate;Diethyl-(4-brombenzyl)malonat;2-(4-Bromo-benzyl)-malonic acid diethyl ester;diethyl 2-[(4-bromophenyl)methyl]propanedioate;1,3-diethyl 2-[(4-bromophenyl)methyl]propanedioate;Propanedioic acid, 2-[(4-bromophenyl)methyl]-, 1,3-diethyl ester
CBNumber:
CB51009775
Molecular Formula:
C14H17BrO4
Molecular Weight:
329.19
MDL Number:
MFCD00017852
MOL File:
70146-78-0.mol
MSDS File:
SDS
Last updated:2026-09-12 18:53:02
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2-(4-Bromo-benzyl)-malonic acid diethyl ester Properties

Boiling point 193-198 °C(Press: 14 Torr)
Density 1.344±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 12.35±0.59(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H315-H319
Precautionary statements  P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P405

2-(4-Bromo-benzyl)-malonic acid diethyl ester price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS111016 Diethyl 2-(4-bromobenzyl)malonate 98% 70146-78-0 1g $160 2026-06-04 Buy
Activate Scientific AS111016 Diethyl 2-(4-bromobenzyl)malonate 98% 70146-78-0 5g $515 2026-06-04 Buy
Matrix Scientific 296993 Diethyl 2-(4-bromobenzyl)malonate 70146-78-0 250.00mg $50 2026-05-19 Buy
Matrix Scientific 296993 Diethyl 2-(4-bromobenzyl)malonate 70146-78-0 1.00g $108 2026-05-19 Buy
Matrix Scientific 296993 Diethyl 2-(4-bromobenzyl)malonate 70146-78-0 5.00g $367 2026-05-19 Buy
Product number Packaging Price Buy
AS111016 1g $160 Buy
AS111016 5g $515 Buy
296993 250.00mg $50 Buy
296993 1.00g $108 Buy
296993 5.00g $367 Buy

2-(4-Bromo-benzyl)-malonic acid diethyl ester Chemical Properties, Uses, Production

Synthesis

4-Bromobenzyl bromide

589-15-1

Diethyl malonate

105-53-3

2-(4-BROMO-BENZYL)-MALONIC ACID DIETHYL ESTER

70146-78-0

Sodium metal (5.82 g, 0.25 mol) was added to ethanol (240 mL) and stirred until the sodium was completely dissolved. 1-Bromo-4-bromomethylbenzene (37.35 g, 0.15 mol) and diethyl malonate (78 g, 0.49 mol) were then added. The reaction mixture was slowly heated to reflux overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in distilled water and extracted with ether. The organic layer was washed sequentially with 0.5 N aqueous hydrochloric acid and saturated brine, dried over anhydrous sodium sulfate and concentrated to give diethyl 2-(4-bromobenzyl)malonate (40 g, 85% yield).

References

[1] Patent: WO2010/105179, 2010, A2. Location in patent: Page/Page column 76
[2] Journal of Organic Chemistry, 1984, vol. 49, # 22, p. 4226 - 4237
[3] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1994, vol. 30, # 8, p. 905 - 915
[4] Khimiya Geterotsiklicheskikh Soedinenii, 1993, # 8, p. 1052 - 1062
[5] Tetrahedron Asymmetry, 2001, vol. 12, # 4, p. 585 - 596

2-(4-Bromo-benzyl)-malonic acid diethyl ester Preparation Products And Raw materials

Raw materials

4-Bromobenzyl bromide Diethyl malonate

Preparation Products

6-Bromoindanone 6-Bromo-2,3-dihydro-1H-inden-1-ol

2-(4-Bromo-benzyl)-malonic acid diethyl ester Suppliers

Global Suppliers ( 33)
Supplier Tel Email Country ProdList Advantage
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
AAB-PHARMA LIMITED 025-66800956 18800000000 sales@njdmchem.com China 4200 50
Beijing YiboYuntian Technology Co., Ltd. 13811826434 lichen13811826434@126.com China 702 58
Aikon International Limited 025-66113011 19370895928 qzhang@aikonchem.com China 15390 58
Changzhou green chemical co., LTD 0519-82733646 13814799543 sales_01@salutchem.com China 108 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 021-4009004166/18616739031 18616739031 3007523370@qq.com China 40000 58
Blocksynth Pharmaceutical Technology Co.,Ltd 0086-19817745290; 19817745290 bd@blocksynth.com China 5971 58
Career Henan Chemica Co +86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
Tianjin Nuokang Pharmaceutical Technology Co., Ltd. 022-23989838 13810451150 44766350@qq.com China 2725 58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd. 13611835272 13611835272 mmwang@sunwaypharm.com China 44090 58
Supplier Advantage
Shanghai Topbiochem Technology Co., Ltd 58
AAB-PHARMA LIMITED 50
Beijing YiboYuntian Technology Co., Ltd. 58
Aikon International Limited 58
Changzhou green chemical co., LTD 58
Shanghai Jizhi Biochemical Technology Co. Ltd. 58
Blocksynth Pharmaceutical Technology Co.,Ltd 58
Career Henan Chemica Co 58
Tianjin Nuokang Pharmaceutical Technology Co., Ltd. 58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd. 58

View Latest Price from 2-(4-Bromo-benzyl)-malonic acid diethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-(4-BROMO-BENZYL)-MALONIC ACID DIETHYL ESTER pictures 2025-04-04 2-(4-BROMO-BENZYL)-MALONIC ACID DIETHYL ESTER
70146-78-0
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

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Diethyl-(4-brombenzyl)malonat Propanedioic acid, 2-[(4-bromophenyl)methyl]-, 1,3-diethyl ester diethyl 2-[(4-bromophenyl)methyl]propanedioate 1,3-diethyl 2-[(4-bromophenyl)methyl]propanedioate diethyl 2-(4-broMobenzyl)Malonate 2-(4-Bromo-benzyl)-malonic acid diethyl ester 70146-78-0