Ethylmalonic acid
- CAS No.
- 601-75-2
- Chemical Name:
- Ethylmalonic acid
- Synonyms
- 2-Ethylmalonic acid;2-Ethylmalonicaci;Ethylmalonic acid;RARECHEM DK HD C012;EthylmalonicAcid>2-ethylpropanedioate;Malonic acid, ethyl-;Ethyl propoinic acid;Ethylmalonicacid,98%;Ethylmalonic acid 97%
- CBNumber:
- CB1782664
- Molecular Formula:
- C5H8O4
- Molecular Weight:
- 132.11
- MDL Number:
- MFCD00002668
- MOL File:
- 601-75-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 112-114 °C (lit.) |
|---|---|
| Boiling point | 292.77°C (rough estimate) |
| Density | 1.5633 (rough estimate) |
| refractive index | 1.4016 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | pK1:2.90(0);pK2:5.55(+1) (25°C) |
| color | Off-White |
| Water Solubility | Soluble in water, methanol (very faint turbidity), and ethanol. |
| BRN | 774334 |
| InChI | 1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H,2H2,1H3,(H,6,7)(H,8,9) |
| InChIKey | UKFXDFUAPNAMPJ-UHFFFAOYSA-N |
| SMILES | CCC(C(O)=O)C(O)=O |
| CAS DataBase Reference | 601-75-2(CAS DataBase Reference) |
| FDA UNII | 432NF49DFG |
| NIST Chemistry Reference | Ethylmalonic acid(601-75-2) |
| UNSPSC Code | 12162002 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29171990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
Ethylmalonic acid price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 102687 | Ethylmalonic acid 97% | 601-75-2 | 5g | $75.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 102687 | Ethylmalonic acid 97% | 601-75-2 | 50g | $384 | 2026-04-30 | Buy |
| TCI Chemical | E0137 | Ethylmalonic Acid >98.0%(T) | 601-75-2 | 5g | $90 | 2026-04-30 | Buy |
| TCI Chemical | E0137 | Ethylmalonic Acid >98.0%(T) | 601-75-2 | 25g | $363 | 2026-04-30 | Buy |
| Cayman Chemical | 44091 | Ethylmalonic Acid ≥98% | 601-75-2 | 1g | $28 | 2026-04-30 | Buy |
Ethylmalonic acid Chemical Properties,Uses,Production
Chemical Properties
white to faintly pink crystalline powder
Uses
Ethylmalonic acid is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.
Definition
ChEBI: Ethylmalonic acid is a dicarboxylic acid obtained by substitution of one of the methylene hydrogens of malonic acid by an ethyl group. It has a role as a human metabolite. It is a dicarboxylic acid and a dicarboxylic fatty acid. It is functionally related to a malonic acid. It is a conjugate acid of an ethylmalonate and an ethylmalonate(2-).
Synthesis
6148-64-7
601-75-2
Step 2: In a 250 mL three-necked flask equipped with a magnetic stirrer, a dosing funnel and a thermometer, monoethyl malonate potassium salt (17.77 g, 104.49 mmol) was dissolved in 18 mL of water. The reaction mixture was cooled in an ice bath and 8 mL of concentrated hydrochloric acid (about 2 mL) was added slowly and dropwise. Upon completion of the reaction, the mixture was filtered to remove the resulting KCl precipitate and the precipitate was washed with ether (3 x 50 mL). The filtrate was separated and the aqueous phase was further extracted with ether (3 x 50 mL). All ether phases were combined, dried with anhydrous MgSO4, filtered and concentrated under reduced pressure to give the colorless oily product ethylmalonic acid (13.45 g, 82% overall yield in two steps).
IC 50
Human Endogenous Metabolite
References
[1] Patent: US6780887, 2004, B1
Ethylmalonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
View Lastest Price from Ethylmalonic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | Ethylmalonic acid
601-75-2
|
$29.00 | 99.88% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-04 | Ethylmalonic acid
601-75-2
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2019-07-06 | ETHYLMALONIC ACID
601-75-2
|
$1.00 | 1KG | 98% | 1ton | Career Henan Chemical Co |
-
- Ethylmalonic acid
601-75-2
- $29.00
- 99.88%
- TargetMol Chemicals Inc.
-
- Ethylmalonic acid
601-75-2
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- ETHYLMALONIC ACID
601-75-2
- $1.00
- 98%
- Career Henan Chemical Co
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