Ranolazine
- CAS No.
- 122312-55-4
- Chemical Name:
- Ranolazine
- Synonyms
- Ranolazine USP/EP/BP;(Mu7-((diosmin heptasulfato)(7-)))tetracontahydroxytetradecaaluminum
- CBNumber:
- CB51031990
- Molecular Formula:
- C28H61Al16O79S8
- Molecular Weight:
- 2349.95
- MDL Number:
- MFCD00868355
- MOL File:
- 122312-55-4.mol
| InChIKey | PVVSBYKNFRRMPR-QGYGKPRUNA-A |
|---|---|
| FDA UNII | P764IU074T |
Ranolazine Chemical Properties,Uses,Production
Uses
Ranolazine is a novel gastric mucosal protectant used to treat peptic ulcers.
Description
Dosmalfate, a heptakis(hydrogensulfate) aluminium complex of diosmin, was launched in Spain for the prevention and treatment of gastroduodenal lesions induced by NSAID therapy. Dosmalfate can be prepared from diosmin by initial treatment with a pyridine sulfur trioxide complex followed by sodium hydroxide and finally aluminium hydroxychloride. In several pharmacological models of acute and chronic ulcers, this new cytoprotective agent has demonstrated significant protection against damage to the gastric mucosa or esophagus erosion, hemorrhage or perforation. Several mechanisms of action could be involved, partly mediated by the endogenous prostaglandins. In several clinical studies with patients receiving long-term NSAID therapy for chronic inflammatory disease, the efficacy of dosmalfate in preventing gastric ulcer was high and comparable to that of misoprostol, but with significantly less adverse events. In rats and humans, dosmalfate, administered orally at very high doses, displayed a very poor absorption and consequently, a very low incidence of side effects, particularly on CNS, cardiovascular or respiratory systems.
Originator
Faes (Spain)
brand name
Diotul
Ranolazine Preparation Products And Raw materials
Raw materials
Preparation Products
Ranolazine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Foshan Nanhai Beisha Pharmaceutical Co., Ltd. | -- | bsyrylq@163.net | China | 22 | 60 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Raw material medicin reagent co.,Ltd | sales@njromanme.com | China | 4511 | 58 | |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-17392587031 | 1059@dideu.com | China | 9983 | 58 |
| Jinan ponder chemical co. LTD | 0531-0000 | thinklifescience@163.com | China | 19684 | 58 |
| Wuhan Yanzhe Technology Co., Ltd | 15527250409 | wenhaotian12@163.com | China | 4152 | 58 |
| Sinoway Industrial co., ltd. | +86-0592-5800732 +86-13806035118 | xie@china-sinoway.com | China | 1366 | 58 |
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