Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
- CAS No.
- 475221-20-6
- Chemical Name:
- Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
- Synonyms
- NEP1-40;NOGO-66 (1-40);PubChem ID: 90488731;NEP(1-40)、Nogo-66 (1-40);Nogo Extracellular Peptide;M.W. 4625.11 C206H324N56O65;NOGO EXTRACELLULAR PEPTIDE, 1-40;NOGO-66 (1-40) ANTAGONIST PEPTIDE;NEP1-40; NOGO EXTRACELLULAR PEPTIDE; 1-40;Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2
- CBNumber:
- CB5110481
- Molecular Formula:
- C206H324N56O65
- Molecular Weight:
- 4625.11
- MDL Number:
- MFCD06411437
- MOL File:
- 475221-20-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | -20°C |
|---|---|
| solubility | H2O: 1 mg/mL |
| form | solid |
| color | white |
| Water Solubility | Soluble to 1 mg/ml in water |
| Sequence | Ac-Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH2 |
| UNSPSC Code | 12352202 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N7161 | Nogo-66(1-40) antagonist peptide ≥84% (HPLC) | 475221-20-6 | 1mg | $637 | 2026-04-30 | Buy |
| Biosynth | PP50250 | NEP(1-40) | 475221-20-6 | 1mg | $343.75 | 2026-06-04 | Buy |
| Biosynth | PP50250 | NEP(1-40) | 475221-20-6 | 10mg | $2062.5 | 2026-06-04 | Buy |
| Biosynth | PP50250 | NEP(1-40) | 475221-20-6 | 100mg | $5500 | 2026-06-04 | Buy |
| ChemScene | CS-0029080 | NEP(1-40) 99.40% | 475221-20-6 | 1mg | $433 | 2026-06-04 | Buy |
Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Chemical Properties, Uses, Production
Uses
Nogo-66(1-40) antagonist peptide has been used as a Nogo-66 receptor antagonist peptide:
- to study the preliminary therapeutic effect after inhibition of Nogo-A in the cauda equina compression (CEC) model
- to determine the effects of Nogo-A/NgR1 on autophagic activation
- to study its role in Nogo-B mediated axonal branching using Schwann cells and sensory neurons of mice
Biochem/physiol Actions
Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. Nogo-66 can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). Competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent.
in vivo
NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies[1].
| Animal Model: | 74 male Sprague-Dawley rats (328-377 g)[1]. |
| Dosage: | 89 μg/kg (97.5% PBS and 2.5% DMSO). |
| Administration: | IP, 15 min and 19 h post-injury. |
| Result: | Reduced NgR function immediately post-injury. Increased number of amoeboid microglia/macrophages at 2 days post-injury |
storage
Store at -20°C
Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4724 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
