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(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate structure

CAS No.: 114676-69-6

Chemical Name:: (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

Synonyms: (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate;N-Boc-cis-D-Hyp-Ome;CIS-1-BOC-4-HYDROXY-D-PROLINATE;Methyl cis-1-Boc-4-hydroxy-D-prolinate;Boc-cis-4-Hydroxy-D-proline methyl ester;N-Boc-cis-4-hydroxy-D-proline methyl ester;1-tert-butyl 2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate;Boc-Cis-D-Hyp-OMe;cis-Boc-d-Hyp-Ome;(2R,4R)-1-Boc-4-hydroxypyrroL

CBNumber:: CB51118684

Molecular Formula:: C11H19NO5

Molecular Weight:: 245.27

MDL Number:: MFCD00797548

MOL File:: 114676-69-6.mol

MSDS File:: SDS

Last updated:2026-05-28 02:12:43

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(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Properties

Melting point	76 °C
Boiling point	335.2±42.0 °C(Predicted)
alpha	63° (C=1,EtOH)
Density	1.216±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
pka	14.27±0.40(Predicted)
form	Powder
color	White
InChI	InChI=1S/C11H19NO5/c1-11(2,3)17-10(15)12-6-7(13)5-8(12)9(14)16-4/h7-8,13H,5-6H2,1-4H3/t7-,8-/m1/s1
InChIKey	MZMNEDXVUJLQAF-HTQZYQBOSA-N
SMILES	N1(C(OC(C)(C)C)=O)C[C@H](O)C[C@@H]1C(OC)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HS Code

2933998090

NFPA 704

	1
2		0

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate price More Price(72)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B5857	N-(tert-Butoxycarbonyl)-cis-4-hydroxy-D-proline Methyl Ester >97.0%(GC)	114676-69-6	1g	$18	2026-04-30	Buy
TCI Chemical	B5857	N-(tert-Butoxycarbonyl)-cis-4-hydroxy-D-proline Methyl Ester >97.0%(GC)	114676-69-6	5g	$40	2026-04-30	Buy
AstaTech	63840	METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE 97%	114676-69-6	25G	$34	2026-04-30	Buy
AstaTech	63840	METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE 97%	114676-69-6	100G	$97	2026-04-30	Buy
ChemScene	CS-W002680	(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate ≥97%	114676-69-6	5g	$12	2026-06-04	Buy

Product number	Packaging	Price	Buy
B5857	1g	$18	Buy
B5857	5g	$40	Buy
63840	25G	$34	Buy
63840	100G	$97	Buy
CS-W002680	5g	$12	Buy

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Chemical Properties,Uses,Production

Uses

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate (N-Boc-cis-4-hydroxy-D-proline methyl ester) is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

IC 50

Non-cleavable Linker

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate synthesis

Synthesis of (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate from Di-tert-butyl dicarbonate and D-Proline, 4-hydroxy-, methyl ester, hydrochloride (1:1), (4R)-

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S-trans)-(9CI) Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 1,2-Pyrrolidinedicarboxylic acid, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Suppliers

Global( 202)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZhengZhou Yimi Pharma R&D Co.,LTD.	15393710992	375000787@QQ.com	China	22	58
Shanghai Xinxin Pharmaceutical Technology Co., Ltd.	13671725141	hickle@yeah.net	China	768	58
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Sichuan Tongsheng Amino acids Co.,Ltd.	0838-2274206 17340404235	sales@biots.cn	China	300	66
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66

Supplier	Advantage
ZhengZhou Yimi Pharma R&D Co.,LTD.	58
Shanghai Xinxin Pharmaceutical Technology Co., Ltd.	58
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
Sichuan Tongsheng Amino acids Co.,Ltd.	66
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Jia Xing Isenchem Co.,Ltd	66

View Lastest Price from (2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-02	N-tert-Butoxycarbonyl-cis-4-hydroxy-D-proline methyl ester 114676-69-6		20kg	99%	20 tons	Qingdao RENAS Polymer Material Co., Ltd.
	2019-12-20	METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE 114676-69-6	$1.00	1ASSAYS	97-99%	1000KGS	Career Henan Chemical Co

N-tert-Butoxycarbonyl-cis-4-hydroxy-D-proline methyl ester
114676-69-6
$0.00
99%
Qingdao RENAS Polymer Material Co., Ltd.

METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE
114676-69-6
$1.00
97-99%
Career Henan Chemical Co

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Spectrum

METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE (114676-69-6)¹HNMR

114676-69-6((2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate )Related Search:

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(2R,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylicacid 1-(1,1-dimethylethyl) 2-methyl ester (2R,4R)-1-tert-butyl 2-Methyl 4-hydroxypyrrolidine-1,2-dicarboxy (2R,4R)-1-tert-butyl 2-Methyl 4-hydro×ypyrrolidine-1,2-dicarbo×ylate Boc-Cis-D-Hyp-OMe Methy cis-1-Boc-4-hydroxy-D-prolinate Methyl cis-Boc-4-hydroxy-D-prolinate 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)- 1-tert-butyl 2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate N-tert-Butoxycarbonyl-cis-4-hydroxy-D-proline methyl ester (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate Boc-cis-4-Hydroxy-D-proline methyl ester (Tert-Butoxy)Carbonyl D-cis-Hyp-OMe Methyl (2R,4R)-1-Boc-4-hydroxypyrrolidine-2-carboxylate (2R,4R)-N-Boc-4-hydroxyproline methyl ester (2R,4R)-N-Boc-cis-4-hydroxy-D-proline methyl ester (2R,4R)-1-Boc-4-hydroxypyrroL N-Boc-cis-4-hydroxy-D-prolinemethylester,95% (2R,4R)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE USP/EP/BP O1-tert-Butyl O2-methyl (2R,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate cis-Boc-d-Hyp-Ome 1-(1,1-Dimethylethyl) 2-methyl (2R,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate BOC cis D hydroxyproline methyl ester (2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate/METHYL CIS-1-BOC-4-HYDROXY-D-PROLINATE Methyl cis-1-Boc-4-hydroxy-D-prolinate, CAS 114676-69-6 1-(tert-Butyl) 2-methyl (2R,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate CIS-1-BOC-4-HYDROXY-D-PROLINATE Methyl cis-1-Boc-4-hydroxy-D-prolinate N-Boc-cis-4-hydroxy-D-proline methyl ester N-Boc-cis-D-Hyp-Ome 114676-69-6