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N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Structure
N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid structure
CAS No.
7365-44-8
Chemical Name:
N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid
Synonyms
TES;Tes Buffer;N-TRIS(HYDROXYMETHYL)METHYL-2-AMINOETHANESULFONIC ACID;TES,2-[(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]ethanesulfonic acid, N-[Tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid, TES free acid;TESS;C05353;TESS-2;Tris TES;8-Fluoro-1;OmniPur TES
CBNumber:
CB5114267
Molecular Formula:
C6H15NO6S
Molecular Weight:
229.25
MDL Number:
MFCD00007532
MOL File:
7365-44-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-24 18:42:22
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N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Properties

Melting point ~225 °C (dec.)
Density 1.260 (estimate)
refractive index 1.5500 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility H2O: 1 M at 20 °C, clear, colorless
form Crystalline Powder
color White
PH Range 6.8 - 8.2
Odor Odorless
PH 3.5-5.0 (25℃, 1M in H2O)
pka 7.5(at 25℃)
Water Solubility SOLUBLE
λmax λ: 260 nm Amax: 0.055
λ: 280 nm Amax: 0.045
Merck 14,9176
BRN 1957061
InChI 1S/C6H15NO6S/c8-3-6(4-9,5-10)7-1-2-14(11,12)13/h7-10H,1-5H2,(H,11,12,13)
InChIKey JOCBASBOOFNAJA-UHFFFAOYSA-N
SMILES [S](=O)(=O)([O-])CC[N+H2]C(CO)(CO)CO
CAS DataBase Reference 7365-44-8(CAS DataBase Reference)
FDA UNII L173DK6289
EPA Substance Registry System Ethanesulfonic acid, 2-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]- (7365-44-8)
Absorption ≤0.045 at 280 in H2O at 1M
≤0.055 at 260 in H2O at 1M
UNSPSC Code 12161703
NACRES NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  1
TSCA  TSCA listed
HS Code  29221980
Storage Class 11 - Combustible Solids
NFPA 704
1
2 0

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid price More Price(77)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 5.05147 OmniPur® TES TES, CAS 7365-44-8 , is a Zwitterionic buffer that is useful in the pH range of 6.8-8.2. 7365-44-8 100G $203 2026-04-30 Buy
Sigma-Aldrich 1.10695 N-[Tris(hydroxymethyl)-methyl]-2-aminoethanesulfonic acid Buffer substance TES 7365-44-8 250 g $466 2026-04-30 Buy
Sigma-Aldrich 1.10695 N-[Tris(hydroxymethyl)-methyl]-2-aminoethanesulfonic acid Buffer substance TES 7365-44-8 10 kg $9980 2026-04-30 Buy
Sigma-Aldrich 5.05147 OmniPur® TES TES, CAS 7365-44-8 , is a Zwitterionic buffer that is useful in the pH range of 6.8-8.2. 7365-44-8 1KG $1060 2025-07-31 Buy
Sigma-Aldrich 93359 TES BioUltra, ≥99.5% (calc. based on dry substance, T) 7365-44-8 25g $246 2023-06-20 Buy
Product number Packaging Price Buy
5.05147 100G $203 Buy
1.10695 250 g $466 Buy
1.10695 10 kg $9980 Buy
5.05147 1KG $1060 Buy
93359 25g $246 Buy

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Chemical Properties, Uses, Production

Chemical Properties

White/clear crystalline powder

Uses

A structural analog to Tris buffer.

Uses

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid (TES) probably exists in solution as a zwitterion. Because the pKa is 7.4 (physiological pH) this buffer has considerable potential for a variety of biological applications. A buffer using TES free acid can be prepared by titrating the free acid (sc-206102) with sodium hydroxide to the desired pH, using about a half-equivalent of NaOH. Alternatively, solutions of equimolar TES free acid and TES sodium (sc-264384) can be mixed to attain a buffer of the desired pH.  It has been shown to be toxic in vitro, but this toxicity may be due to its ability to form metal chelate complexes that are toxic for cells. TES is a commonly used biological buffering agent.

Definition

ChEBI: N-tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid is a Good's buffer substance, pKa = 7.5 at 20 ℃. It is a member of ethanolamines, an amino sulfonic acid and a TES. It is functionally related to a taurine. It is a tautomer of a N-tris(hydroxymethyl)methyl-2-ammonioethanesulfonate.

Purification Methods

Crystallise the acid from hot EtOH containing a little water.

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid synthesis

107-04-0
77-86-1
7365-44-8
Synthesis of N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid from 1-Bromo-2-chloroethane and Tris(hydroxymethyl)aminomethane

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Preparation Products And Raw materials

Raw materials

Sodium ethylenesulphonate Tris(hydroxymethyl)aminomethane 1-Bromo-2-chloroethane

Preparation Products

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Suppliers

Global Suppliers ( 484)
Supplier Tel Email Country ProdList Advantage
Nanjing Search Biotech Co., Ltd +86-025-81682922 +86-13515111588 sales@searchbio.com.cn China 137 68
Hunan Hengfei bio-pharmaceutical Co. , Ltd. 0746-6222194 13874779848 57182844@qq.com China 52 58
Jiangsu Magic Biotechnology Co., Ltd 13685102975 13921770081 svp01@magicbiotech.cn China 498 58
Hu' nan Yunbang Pharmaceutical Co., Ltd. 88532689 15386497078 yunbang@yunbangapi.com China 6935 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Nanjing Search Biotech Co., Ltd 68
Hunan Hengfei bio-pharmaceutical Co. , Ltd. 58
Jiangsu Magic Biotechnology Co., Ltd 58
Hu' nan Yunbang Pharmaceutical Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
future industrial shanghai co., ltd 65
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61

Related articles

View Latest Price from N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TES pictures 2026-09-16 TES
7365-44-8
 $5.00 1kg ≥99% 200mt/year Jinan Finer Chemical Co., Ltd
2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid/TES pictures 2026-09-16 2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid/TES
7365-44-8
 1KG 99%-101% 500KGS WUHAN FORTUNA CHEMICAL CO., LTD
2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid pictures 2026-08-20 2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid
7365-44-8
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
  • TES pictures
  • TES
    7365-44-8
  • $5.00
  • ≥99%
  • Jinan Finer Chemical Co., Ltd

N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid Spectrum

2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid(7365-44-8)1HNMR2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid(7365-44-8)IR12-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid(7365-44-8)IR22-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid(7365-44-8)Raman

7365-44-8 (N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid) Related Search:

ABTS Tris-MOPS Buffer,10× Sodium Citrate buffer(0.1mol/L, pH4.5, sterile) CHAPS TRIS hydrochloride
PBS Tablets Phosphate buffer containing Tween 20 (PBS-T tablets) DIPSO 3-[N,N-Bis(hydroxyethyl)amino]-2-hydroxypropanesulphonic acid sodium salt TAPSO
3-[N-Tris(hydroxymethyl)methylamino]-2-hydroxypropanesulfonic acid sodium salt N-[Tris(hydroxymethyl)methyl]-3-aminopropanesulfonic acid sodium salt TAPS N-(Tris(hydroxymethyl)methyl)-2-aminoethanesulfonic acid sodium salt N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic Acid
Tris(hydroxymethyl)aminomethane N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid-d15 2-([2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]amino)ethanesulfonic acid hemisodium salt

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N-[2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL]TAURINE N-TRIS(HYDROXYMETHYL)METHYL-2-AMINO-ETHANESULPHONIC ACID N-TRIS(HYDROXYMETHYL)METHYL-2-AMINOETHANESULFONIC ACID 2-[TRIS(HYDROXYMETHYL)METHYL]-2-AMINOETHANE SULFONIC ACID 2-[TRIS(HYDROXYMETHYL)METHYLAMINO]-1-ETHANESULFONIC ACID 2-[[TRIS(HYDROXYMETHYL)METHYL]AMINO]ETHANESULFONIC ACID 2-([2-HYDROXY-1,1-BIS(HYDROXYMETHYL)ETHYL]AMINO)ETHANESULFONIC ACID TES free acid 2-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]-ethanesulfonicaci Ethanesulfonicacid,2-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]- N-TRIS(HDYROXYMETHYL)METHYL-2-AMINOETHANESULFONIC ACID ANALYT. GRADE TES,2-[(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]ethanesulfonic acid, N-[Tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid, TES free acid 2-[(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl) C05353 N-TrisMethyl-2-aMinoethanesulfonic Acid-d15 2-[Tris(hydroxyMethyl)MethylaMino]-1-ethanesulfonic acid (TES) N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid TES Vetec(TM) reagent grade, 99% N-[Tris(hydroxymethyl)metyl]-2-aminopropanesulfonic acid Tris TES TES, BIOPERFORMANCE CERTIFIED, CELL& OmniPur TES 2-(tris(hydroxymethyl)methylamino)ethane-1-sulphonic acid TES, for biochemistry, 99+% Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid 2-(Tris(hydroxymethyl)methylamino)ethan-1-sulfonsure TES FREE ACID SIGMAULTRA TES FREE ACID CELL CULTURE TESTED TES FREE ACID, BIOTECHNOLOGY PERFORMANCE CERTIFIED N-TRIS(HYDROXYMETHYL)METHYL- 2-AMINO-ETHANESULPHONIC ACID (TES) CELL CULTURE REAGENT N-TRIS(HYDROXYMETHYL)METHYL- 2-AMINO-ETHANESULPHONIC ACID (TES) 99+% MOLECULAR BIOLOGY REAGENT N-TRIS(HYDROXYMETHYL)METHYL- 2-AMINO-ETHANESULPHONIC ACID (TES) CRYSTALLINE Tes2-[Tris(Hydroxymethyl)Methylamino]-1-EthanesulfonicAcid N-Tris-(hydroxymethyl)-Methyl-2-Amino Ethansulfonic Acid TES, for biochemistry, 99% N-TRIS(HYDROXYMETHYL)METHYL-2-AMINOETHANESULFONIC ACID TES TES (N-(TRIS(HYDROXYMETHYL)METHYL)-2-AMINOETHANESULFONIC ACID) N-Tris-(hydroxymethyl)methyl-2-aminoethanesulphonic acid >99% N-TRIS(HYDROXYMETHYL)METHYL-2-AMINOETHANE-SULPHONIC ACID extrapure N-[Tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid, TES free acid, 2-[(2-Hydroxy-1,1-bis(hydroxymethyl)ethyl)amino]ethanesulfonic acid 2-[[1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]ethanesulfonic acid N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid ,99% TES, 99%, FOR BIOCHEMISTRY 2-[[1,1-Bis(hydroxymethyl)-2-hydroxyethyl]amino]ethanesulfonic acid 2-[1,1-Bis(hydroxymethyl)-2-hydroxyethylamino]ethane-1-sulfonic acid N-tris(hydroxymethyl)methyl-2-aminoethanesulfonicaci 2-[Tris(hydroxymethyl)methylamino]-1-ethanesulfonic acid ISO 9001：2015 REACH N-tris-(Hydroxymethyl)-methyl-2-amino ethansulfonic acid (TES) 3-cd]indol-6-one 5-tetrahydro-6H-azepino[5 8-Fluoro-1 N-[Tris(hydroxymethyl)metyl]-2-aminoethanesulfonic acid 2- [[Tri (hydroxymethyl) methyl] amino] Ethanesulfonic acid TES 2- [[tri (hydroxymethyl) methyl] amino] ethanesulfonic acid/TRIS ethanesulfonic acid N-Tri(hydroxymethyl)methyl-2-aminoethanesulfonic acid EZNA MICROELUTE GEL EXTRACTION KIT Tes(N-Tris[Hydroxymethyl]Methyl-2-AminoethanesulfonicAcid)Buffer TES,BIOLOGICALBUFFER