Israpafant
- CAS No.
- 117279-73-9
- Chemical Name:
- Israpafant
- Synonyms
- Y 24180;Israpafant;Y-24180;Y24180;Israpafant (Y-24180;Benzaldehyde,5-methoxy-4-nitro-;4-(2-chlorophenyl)-2-(4-isobutylphenethyl)-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine;4-(2-Chlorophenyl)-2-[2-(4-isobutylphenyl)ethyl]-6,9-dimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 4-(2-chlorophenyl)-6,9-dimethyl-2-[2-[4-(2-methylpropyl)phenyl]ethyl]-;7-(2-chlorophenyl)-9,13-dimethyl-4-[2-[4-(2-methylpropyl)phenyl]ethyl]-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaene
- CBNumber:
- CB51178985
- Molecular Formula:
- C28H29ClN4S
- Molecular Weight:
- 489.07
- MDL Number:
- MFCD00873428
- MOL File:
- 117279-73-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 129.5-131.5° |
|---|---|
| FDA UNII | O3MCV749SW |
Israpafant price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | SEA27973 | Israpafant | 117279-73-9 | 10mg | $896.6 | 2026-06-05 | Buy |
| Biosynth | SEA27973 | Israpafant | 117279-73-9 | 25mg | $1462 | 2026-06-05 | Buy |
| Biosynth | SEA27973 | Israpafant | 117279-73-9 | 50mg | $2339 | 2026-06-05 | Buy |
| DC Chemicals | DC22896 | Israpafant >98% | 117279-73-9 | 5mg | $650 | 2026-05-24 | Buy |
| J&W Pharmlab | 99R0018 | ISRAPAFANT 96% | 117279-73-9 | 10mg | $598 | 2026-05-21 | Buy |
Israpafant Chemical Properties,Uses,Production
Uses
Israpafant (Y-24180) is a potent, selective and long-acting platelet activation factor (PAF) receptor antagonist with IC50s of 0.84 nM and 3.84 nM against PAF-induced human and rabbit platelet aggregation, respectively. Israpafant stimulates both extracellular Ca2+ influx and intracellular Ca2+ release in prostate cancer cells. Israpafant suppresses the allergic cutaneous reactions including eosinophilia, cytokine production, edema and erythema in mice[1][2].
References
[1] Takehara S, et al. Pharmacological actions of Y-24180, a new specific antagonist of platelet activating factor (PAF): II. Interactions with PAF and benzodiazepine receptors. Prostaglandins. 1990 Dec;40(6):571-83. DOI:10.1016/0090-6980(90)90002-d
[2] Jan C R, Chao Y Y. Novel effect of Y-24180, a presumed specific platelet activation factor receptor antagonist, on Ca2+ levels and growth of human prostate cancer cells. Cellular signalling, 2004, 16(8): 959-965.
Israpafant Preparation Products And Raw materials
Raw materials
Preparation Products
Israpafant Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| Shanghai zhigan biotechnology co., LTD | zhiqianbio@126.com | China | 19765 | 58 | |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| DC Chemicals | 021-58447131 13564518121 | doncunbiosci@gmail.com | China | 618 | 58 |
| Block Chemical Technology (Shanghai) Co., LTD | 021-20432219 13918097649 | li_jinfei@acblock-lab.com | China | 9966 | 58 |
| Qi Qi hang Biotechnology Co., Ltd. | 15870833005 | 2232044025@qq.com | China | 8198 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
