tibenelast
- CAS No.
- 97852-72-7
- Chemical Name:
- tibenelast
- Synonyms
- LY-186655;tibenelast;5,6-Diethoxybenzo[b]thiophene-2-carboxylic acid;Benzo[b]thiophene-2-carboxylic acid, 5,6-diethoxy-
- CBNumber:
- CB51353063
- Molecular Formula:
- C13H14O4S
- Molecular Weight:
- 266.31
- MDL Number:
- MFCD00890221
- MOL File:
- 97852-72-7.mol
- MSDS File:
- SDS
| Boiling point | 440.8±40.0 °C(Predicted) |
|---|---|
| Density | 1.289±0.06 g/cm3(Predicted) |
| pka | 3.54±0.30(Predicted) |
| FDA UNII | H051V8LJ93 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
tibenelast Chemical Properties,Uses,Production
Uses
Tibenelast (LY186655) free acid is a potent and orally active is a phosphodiesterase inhibitor. Tibenelast free acid is an anti-asthma agent Tibenelast free acid increases the heart rate response to isoproterenol (HY-108353). Tibenelast free acid shows anti-anaphylactic shock activity. Tibenelast free acid has the potential for the research of asthma and other respiratory diseases[1][2].
References
[1] Ho PP, et al. Tibenelast, 5,6-diethoxybenzo(B)thiophene-2-carboxylic acid, sodium salt (LY186655), is an orally active anti-asthma compound in the guinea pig. Life Sci. 1990;46(13):917-25. DOI:10.1016/0024-3205(90)90093-7
[2] Schwertschlag US, et al. Effect of tibenelast (a phosphodiesterase inhibitor) and theophylline on isoproterenol-stimulated heart rate, cyclic AMP and norepinephrine levels. Pharmacology. 1993;46(3):142-7. DOI:10.1159/000139039
tibenelast Preparation Products And Raw materials
Raw materials
Preparation Products
tibenelast Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuxi AppTec | 022-59987777 13552403979 | jia_guoqiang@wuxiapptec.com | China | 22344 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20027 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Supplier | Advantage |
|---|---|
| Wuxi AppTec | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
