ChemicalBook >> CAS DataBase List >>berberrubine
berberrubine
- CAS No.
- 15401-69-1
- Chemical Name:
- berberrubine
- Synonyms
- Berberrubine chloride;Chileninone;Beroline;grubbiness;Nerberrubine;berberrubine;Beroline chloride;9-Berberoline chloride;Berberubine chloride form;Berberrubine/Berberrubine chloride
- CBNumber:
- CB51356211
- Molecular Formula:
- C19H16ClNO4
- Molecular Weight:
- 357.78764
- MDL Number:
- MFCD01658905
- MOL File:
- 15401-69-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-04-24 14:58:09
| Product description | Number | Pack Size | Price |
| Berberrubine (chloride) ≥98% | 42515 | 5mg | $52 |
| Berberrubine (chloride) ≥98% | 42515 | 10mg | $98 |
| Berberrubine (chloride) ≥98% | 42515 | 25mg | $207 |
| Berberrubine (chloride) ≥98% | 42515 | 50mg | $311 |
| Berberrubine Chloride | 300000 | 10mg | $446 |
| More product size | |||
| Melting point | 245℃ (DEC.) |
|---|---|
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Off-White to Dark Yellow |
| Stability | Hygroscopic |
| InChI | InChI=1S/C19H15NO4.ClH/c1-22-16-3-2-11-6-15-13-8-18-17(23-10-24-18)7-12(13)4-5-20(15)9-14(11)19(16)21;/h2-3,6-9H,4-5,10H2,1H3;1H |
| InChIKey | GYFSYEVKFOOLFZ-UHFFFAOYSA-N |
| SMILES | [Cl-].O1C([H])([H])OC2=C1C([H])=C1C(=C2[H])C2C([H])=C3C([H])=C([H])C(=C(C3=C([H])[N+]=2C([H])([H])C1([H])[H])O[H])OC([H])([H])[H] |
berberrubine price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 42515 | Berberrubine (chloride) ≥98% | 15401-69-1 | 5mg | $52 | 2026-04-30 | Buy |
| Cayman Chemical | 42515 | Berberrubine (chloride) ≥98% | 15401-69-1 | 10mg | $98 | 2026-04-30 | Buy |
| Cayman Chemical | 42515 | Berberrubine (chloride) ≥98% | 15401-69-1 | 25mg | $207 | 2026-04-30 | Buy |
| Cayman Chemical | 42515 | Berberrubine (chloride) ≥98% | 15401-69-1 | 50mg | $311 | 2026-04-30 | Buy |
| Usbiological | 300000 | Berberrubine Chloride | 15401-69-1 | 10mg | $446 | 2026-06-03 | Buy |
berberrubine Chemical Properties,Uses,Production
Chemical Properties
Soluble in acidic solution, insoluble in petroleum ether, chloroform and other solvents. Derived from the roots of Thalictrum polygamun Muhl.
Uses
Berberrubine Chloride is a novel alkaloid with novel nitric-oxide donating activity. Antitumor and an antimicrobial agent.
Definition
ChEBI: Berberrubine is an alkaloid.
Synthesis
A literature review of various methods to prepare berberrubine:
1. Vacuum pyrolysis; 2. Microwave irradiation; 3. Pyridine hydrochloride fusion; 4. Urea method; 5. Aluminum trichloride method; 6. Esterification-hydrolysis method. Steps for method 2 (microwave) are described in detail.
in vivo
Berberrubine (oral administration; 10-20 mg/kg; 7 days) has a beneficial effect in a mouse colitis model[3].
| Animal Model: | DSS (HY-116282) treated male Balb/c mice aged 6 weeks old[3] |
| Dosage: | 10 and 20 mg/kg |
| Administration: | Oral administration (p.o.); 7 days |
| Result: | Significantly reduced the disease activity index (DAI) with prolonged colon length and increased bodyweight at dose of 20 mg/kg. Significantly ameliorated the DSS-induced colonic pathological alternations and decreased histological scores. Markedly attenuated colonic inflammation by alleviating inflammatory cell infiltration and inhibiting myeloperoxidase (MPO) and cytokines (TNF-α, IFN-γ, IL-1β, IL-6, IL-4 and IL-10) productions in DSS mice. Substantially upregulated the expression of tight junction proteins (zonula occludens-1, zonula occludens-2, claudin-1, occludin) and mRNA expression of mucins (mucin-1 and mucin-2), and decreased the Bax/Bcl-2 ratio. |
berberrubine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 223)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3618 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +86-18080483897 | sales@biopurify.com | China | 4616 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2971 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1922 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2934 | 58 |
| Hubei Ipure Biology Co., Ltd | +8618062405514 | ada@ipurechemical.com | China | 10224 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6290 | 58 |
| Apeloa Pharmaceutical Co., Ltd. | +86-0571-87635730 +8615858229168 | chem1022@hengdian-group.com | China | 1478 | 58 |
View Lastest Price from berberrubine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | berberrubine
15401-69-1
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2023-02-24 | Berberrubine
15401-69-1
|
5mg | ≥90%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
 |
2021-11-02 | berberrubine
15401-69-1
|
$95.00 | 20mg | 99% | 10kg | Baoji Guokang Healthchem co.,ltd |
-
- berberrubine
15401-69-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Berberrubine
15401-69-1
- $0.00
- ≥90%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- berberrubine
15401-69-1
- $95.00
- 99%
- Baoji Guokang Healthchem co.,ltd
15401-69-1(berberrubine)Related Search:
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9-Demethoxy-9-hydroxyberberinium chloride
Beroline chloride
berberrubine
Chileninone
Nerberrubine
9-Hydroxy-10-methoxy-5,6-dihydro-[1,3]dioxolo-[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chlo
Berberubine chloride form
Beroline
BERBERRUBINE,HYDROCHLORIDE,DIHYDRATE
9-hydroxy-10-methoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride
grubbiness
10-methoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium-9-olate
Berberrubine/Berberrubine chloride
Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9-hydroxy-10-methoxy-, chloride (1:1)
9-Berberoline Chloride|||Beroline|||Beroline Chloride|||Berberrubine|||9-Berberoline
Berberrubine chloride, 10 mM in DMSO
Berberrubine chloride
15401-69-1
chemical reagent
pharmaceutical intermediate
phytochemical
reference standards from Chinese medicinal herbs (TCM).
standardized herbal extract
