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ChemicalBook >> CAS DataBase List >>(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride Structure
(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride structure
CAS No.
171482-05-6
Chemical Name:
(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride
Synonyms
Aprepitant HCl;Aprepitant intermediate;APREPITANT INTERMEDIATES;Aprepitant M2 Matabolite;(2R,3S)-2-((R)-1-(3,5-Bi;Aprepitant Impurity 19 HCl;Aprepitant Stage-II (Impurity-A);Aprepitant Impurity 1 Enantiomer HCl;Aprepitant M2 Metabolite (1R, 2R, 3S);(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy
CBNumber:
CB51473341
Molecular Formula:
C20H19ClF7NO2
Molecular Weight:
473.82
MDL Number:
MFCD13183776
MOL File:
171482-05-6.mol
MSDS File:
SDS
Last updated:2025-07-16 09:56:28
Product description Number Pack Size Price
(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)-ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride 95+% 091946 1g $85
APREPITANT-M2 HYDROCHLORIDE 95.00% API0005691 1G $224.7
(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)-ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride 95+% 091946 5g $320
(2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholinehydrochloride Y0384 5g $253
(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)-ethoxy)-3-(4-fluorophenyl)morpholinehydrochloride 95% CM163754 10g $262
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(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride Properties

storage temp. Inert atmosphere,Room Temperature
form solid
Appearance White to off-white Solid
optical activity 69.3°(C=0.01g/ml MEOH)
InChIKey DWCCMKXSGCKMJF-NFEGTRMXNA-N
SMILES O([C@H]1OCCN[C@H]1C1C=CC(F)=CC=1)[C@@H](C1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1)C.Cl |&1:1,6,14,r|

SAFETY

Risk and Safety Statements

Signal word  Danger
Hazard statements  H351-H318
Precautionary statements  P280-P305+P351+P338-P310-P201-P202-P281-P308+P313-P405-P501

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 091946 (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)-ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride 95+% 171482-05-6 1g $85 2021-12-16 Buy
American Custom Chemicals Corporation API0005691 APREPITANT-M2 HYDROCHLORIDE 95.00% 171482-05-6 1G $224.7 2021-12-16 Buy
Matrix Scientific 091946 (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)-ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride 95+% 171482-05-6 5g $320 2021-12-16 Buy
AK Scientific Y0384 (2R,3S)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholinehydrochloride 171482-05-6 5g $253 2021-12-16 Buy
Chemenu CM163754 (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)-ethoxy)-3-(4-fluorophenyl)morpholinehydrochloride 95% 171482-05-6 10g $262 2021-12-16 Buy
Product number Packaging Price Buy
091946 1g $85 Buy
API0005691 1G $224.7 Buy
091946 5g $320 Buy
Y0384 5g $253 Buy
CM163754 10g $262 Buy

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride Chemical Properties,Uses,Production

Uses

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride is an important pharmaceutical intermediate compound whose reaction unit is used in the synthesis of aprepitant intermediates. Arepitane is a neurokinin-1 antagonist analogue. It is used for the management and prevention of chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV) in cancer patients.

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride Suppliers

Global( 238)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 1006 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 973 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Nanjing Gold Pharmaceutical Technology Co. Ltd. 		025-84209270 15906146951 CHINA 115 55
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21597 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29831 58
NINGBO INNO PHARMCHEM CO., LTD. 		13867897135 sales@nbinno.com CHINA 923 58
Jinan Shengqi pharmaceutical Co,Ltd 		86+18663751872 christine@shengqipharm.com CHINA 491 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
Supplier Advantage
Hangzhou ICH Biofarm Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Nanjing Gold Pharmaceutical Technology Co. Ltd. 		55
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
NINGBO INNO PHARMCHEM CO., LTD. 		58
Jinan Shengqi pharmaceutical Co,Ltd 		58
Shandong chuangyingchemical Co., Ltd. 		58

View Lastest Price from (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(2R,3S)-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}-3-(4-FLUOROPHENYL)MORPHOLINE HYDROCHLORIDE pictures 2026-02-19 (2R,3S)-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}-3-(4-FLUOROPHENYL)MORPHOLINE HYDROCHLORIDE
171482-05-6
 0.99 RongNa Biotechnology Co.,Ltd
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride pictures 2026-01-04 (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride
171482-05-6
 US $0.00-0.00 / kg 1kg 99% ≥1kg Hangzhou ICH Biofarm Co., Ltd
(2R,3S)-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}-3-(4-FLUOROPHENYL)MORPHOLINE HYDROCHLORIDE pictures 2023-09-11 (2R,3S)-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}-3-(4-FLUOROPHENYL)MORPHOLINE HYDROCHLORIDE
171482-05-6
 US $80.00 / kg 1kg 99% 10000tons Anhui Ruihan Technology Co., Ltd

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride Spectrum

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride(171482-05-6)1HNMR

171482-05-6((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride)Related Search:

Aprepitant (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine (2R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-5,6-dihydro-2H-1,4-oxazine Fosaprepitant Benzyl Ester Aprepitant
(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate 5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Fosaprepitant
Benzyl dihydrogen phosphate (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine 5-DEOXY-L-ARABINOSE (2R,3R)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Aprepitant Impurity 15
Aprepitant Aprepitant Impurity 19 Aprepitant Impurity 13

1of4

(2R,3S)-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}-3-(4-FLUOROPHENYL)MORPHOLINE HYDROCHLORIDE (2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride (1:1) Aprepitant HCl APREPITANT INTERMEDIATES Aprepitant M2 Metabolite (1R, 2R, 3S) (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)-ethoxy)-3-(4-fluorophenyl)morpholine hydrochlor (2R,3S)-2-((R)-1-(3,5-Bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine hydrochloride (2R, 3S)-2-(1R)-1-(3, 5-BIS (TRIFLUOROMETHYL)-3-(4-FLUOROPHENYL) MORPHOLINE HYDROCHLORIDE Aprepitant M2 Matabolite Aprepitant Stage-II (Impurity-A) Aprepitant intermediate 2R 3S)-2-(1R)-1-3,5-Bis(Trifluoromethyl)Phenyl)Ethoxy)-3-(4Fluoropheny)Morpholine Hydrochloride Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, hydrochloride (1:1), (2R,3S)- Aprepitant int-3 (2R,3S)-2-((R)-1-(3,5-Bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine hydrochloride (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)-ethoxy)-3-(4-fluorophenyl)morpholine hydroch Aprepitant Impurity 1 Enantiomer HCl (2R,3S)-2-((R)-1-(3,5-Bi Morpholine,2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-,hydrochloride, (2R,3S)- (2R,3S)-2-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-3-... (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl) morpholine hydrochlorid (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy (2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl) phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride [APT07] 2-{1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}-3-(4-FLUOROPHENYL)MORPHOLINE HYDROCHLORIDE Aprepitant Impurity 19 HCl (2R,3S)-2-(1R)-L-(3,5-Bis(Trifluoromethyl)Phenyl) Ethoxy )-3-(4-Fluorophenyl) Morpholine Hydrochloride (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]oxy]-3-(4-fluorophenyl)morpholinehydrochloride 171482-05-6 C20H18F7NO2HCl C20H19ClF7NO2 C20H18F7NO2ClH 171482-05-6