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ChemicalBook >> CAS DataBase List >>(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride Structure
(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride structure
CAS No.
171482-05-6
Chemical Name:
(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride
Synonyms
Aprepitant intermediate;Aprepitant HCl;APREPITANT INTERMEDIATES;Aprepitant M2 Matabolite;(2R,3S)-2-((R)-1-(3,5-Bi;Aprepitant Impurity 19 HCl;Aprepitant Stage-II (Impurity-A);Aprepitant Impurity 1 Enantiomer HCl;Aprepitant M2 Metabolite (1R, 2R, 3S);(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy
CBNumber:
CB51473341
Molecular Formula:
C20H19ClF7NO2
Molecular Weight:
473.81
MDL Number:
MFCD13183776
MOL File:
171482-05-6.mol
MSDS File:
SDS
Last updated:2026-07-26 20:01:22
Product description Number Pack Size Price
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride FB102459 5g $900
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride FB102459 2g $900
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride FB102459 1g $900
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride FB102459 0.5g $900
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride FB102459 0.25g $900
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(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride Properties

Melting point 250 °C (decomp)
storage temp. Inert atmosphere,Room Temperature
form solid
Appearance White to off-white Solid
optical activity 69.3°(C=0.01g/ml MEOH)
InChIKey DWCCMKXSGCKMJF-NFEGTRMXNA-N
SMILES O([C@H]1OCCN[C@H]1C1C=CC(F)=CC=1)[C@@H](C1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1)C.Cl |&1:1,6,14,r|

SAFETY

Risk and Safety Statements

Signal word  Danger
Hazard statements  H351-H318
Precautionary statements  P280-P305+P351+P338-P310-P201-P202-P281-P308+P313-P405-P501

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FB102459 (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride 171482-05-6 5g $900 2026-06-04 Buy
Biosynth FB102459 (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride 171482-05-6 2g $900 2026-06-04 Buy
Biosynth FB102459 (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride 171482-05-6 1g $900 2026-06-04 Buy
Biosynth FB102459 (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride 171482-05-6 0.5g $900 2026-06-04 Buy
Biosynth FB102459 (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride 171482-05-6 0.25g $900 2026-06-04 Buy
Product number Packaging Price Buy
FB102459 5g $900 Buy
FB102459 2g $900 Buy
FB102459 1g $900 Buy
FB102459 0.5g $900 Buy
FB102459 0.25g $900 Buy

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride Chemical Properties,Uses,Production

Uses

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride is an important pharmaceutical intermediate compound whose reaction unit is used in the synthesis of aprepitant intermediates. Arepitane is a neurokinin-1 antagonist analogue. It is used for the management and prevention of chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV) in cancer patients.

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride Suppliers

Global( 241)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 1002 58
Anhui Ruihan Technology Co., Ltd 		+undefined17756083858 daisy@anhuiruihan.com China 954 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Nanjing Gold Pharmaceutical Technology Co. Ltd. 		025-84209270 15906146951 CHINA 114 55
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1796 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
NINGBO INNO PHARMCHEM CO., LTD. 		13867897135 sales@nbinno.com CHINA 920 58
Jinan Shengqi pharmaceutical Co,Ltd 		86+18663751872 christine@shengqipharm.com CHINA 490 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5898 58
Supplier Advantage
Hangzhou ICH Biofarm Co., Ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Nanjing Gold Pharmaceutical Technology Co. Ltd. 		55
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
NINGBO INNO PHARMCHEM CO., LTD. 		58
Jinan Shengqi pharmaceutical Co,Ltd 		58
Shandong chuangyingchemical Co., Ltd. 		58

View Lastest Price from (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(2R,3S)-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}-3-(4-FLUOROPHENYL)MORPHOLINE HYDROCHLORIDE pictures 2026-08-12 (2R,3S)-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}-3-(4-FLUOROPHENYL)MORPHOLINE HYDROCHLORIDE
171482-05-6
 0.99 RongNa Biotechnology Co.,Ltd
(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride pictures 2026-08-08 (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine hydrochloride
171482-05-6
 1kg 99% Hangzhou ICH Biofarm Co., Ltd
(2R,3S)-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}-3-(4-FLUOROPHENYL)MORPHOLINE HYDROCHLORIDE pictures 2023-09-11 (2R,3S)-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}-3-(4-FLUOROPHENYL)MORPHOLINE HYDROCHLORIDE
171482-05-6
 $80.00 1kg 99% 10000tons Anhui Ruihan Technology Co., Ltd

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride Spectrum

(2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride(171482-05-6)1HNMR

171482-05-6((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine hydrochloride)Related Search:

Aprepitant (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine (2R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-5,6-dihydro-2H-1,4-oxazine Fosaprepitant Benzyl Ester Aprepitant
(2R)-4-BENZYL-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}MORPHOLIN-3-ONE (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine 4-methylbenzenesulfonate 5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one (2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Fosaprepitant
Benzyl dihydrogen phosphate (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine 5-DEOXY-L-ARABINOSE (2R,3R)-2-[(1S)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride Aprepitant Impurity 15
Aprepitant Aprepitant Impurity 19 Aprepitant Impurity 13

1of4

(2R,3S)-2-{(1R)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}-3-(4-FLUOROPHENYL)MORPHOLINE HYDROCHLORIDE (2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride (1:1) Aprepitant HCl APREPITANT INTERMEDIATES Aprepitant M2 Metabolite (1R, 2R, 3S) (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)-ethoxy)-3-(4-fluorophenyl)morpholine hydrochlor (2R,3S)-2-((R)-1-(3,5-Bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine hydrochloride (2R, 3S)-2-(1R)-1-(3, 5-BIS (TRIFLUOROMETHYL)-3-(4-FLUOROPHENYL) MORPHOLINE HYDROCHLORIDE Aprepitant M2 Matabolite Aprepitant Stage-II (Impurity-A) 2R 3S)-2-(1R)-1-3,5-Bis(Trifluoromethyl)Phenyl)Ethoxy)-3-(4Fluoropheny)Morpholine Hydrochloride Morpholine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-, hydrochloride (1:1), (2R,3S)- Aprepitant int-3 (2R,3S)-2-((R)-1-(3,5-Bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine hydrochloride (2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)-ethoxy)-3-(4-fluorophenyl)morpholine hydroch Aprepitant Impurity 1 Enantiomer HCl (2R,3S)-2-((R)-1-(3,5-Bi Morpholine,2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-,hydrochloride, (2R,3S)- (2R,3S)-2-{(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy}-3-... (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl) morpholine hydrochlorid (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy (2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl) phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine hydrochloride [APT07] 2-{1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY}-3-(4-FLUOROPHENYL)MORPHOLINE HYDROCHLORIDE Aprepitant Impurity 19 HCl (2R,3S)-2-(1R)-L-(3,5-Bis(Trifluoromethyl)Phenyl) Ethoxy )-3-(4-Fluorophenyl) Morpholine Hydrochloride (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]oxy]-3-(4-fluorophenyl)morpholinehydrochloride Aprepitant intermediate 171482-05-6 C20H18F7NO2HCl C20H19ClF7NO2 C20H18F7NO2ClH 171482-05-6