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ChemicalBook >> CAS DataBase List >>5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one

5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one

5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one Structure
5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one structure
CAS No.
321125-94-4
Chemical Name:
5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one
Synonyms
rac-Aprepitant-d4;5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one;3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-, rel-
CBNumber:
CB13627162
Molecular Formula:
C23H21F7N4O3
Molecular Weight:
534.43
MDL Number:
MOL File:
321125-94-4.mol
Last updated:2023-05-15 10:44:02
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5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one Properties

Density 1.51±0.1 g/cm3(Predicted)
solubility DMSO (Slightly), Methanol (Slightly)
pka 8.06±0.20(Predicted)
form Solid
color Off-White to Pale Yellow

5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 25232 rac-Aprepitant-d4 ≥99% deuterated forms (d1-d4) 321125-94-4 500μg $210 2023-01-06 Buy
Cayman Chemical 25232 rac-Aprepitant-d4 ≥99% deuterated forms (d1-d4) 321125-94-4 1mg $378 2023-01-06 Buy
Biosynth WMA12594 Aprepitant β-glucuronide sodium salt 321125-94-4 5mg $1434.3 2026-06-05 Buy
Biosynth WMA12594 Aprepitant β-glucuronide sodium salt 321125-94-4 10mg $2294.9 2026-06-05 Buy
Biosynth WMA12594 Aprepitant β-glucuronide sodium salt 321125-94-4 25mg $4302.75 2026-06-05 Buy
Product number Packaging Price Buy
25232 500μg $210 Buy
25232 1mg $378 Buy
WMA12594 5mg $1434.3 Buy
WMA12594 10mg $2294.9 Buy
WMA12594 25mg $4302.75 Buy

5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one Chemical Properties,Uses,Production

Uses

A metabolite of Aprepitant (A729800).

Definition

ChEBI: Aprepitant is a morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. It has a role as an antidepressant, an antiemetic, a peripheral nervous system drug, a neurokinin-1 receptor antagonist and a substance P receptor antagonist. It is a member of triazoles, a member of morpholines, a cyclic acetal and a member of (trifluoromethyl)benzenes.

5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one Preparation Products And Raw materials

Raw materials

Preparation Products

5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan blalong chemical co. LTD 2710913286@qq.com 1513643261@qq.com China 14227 58
CHINA ISOTOPE CO., LIMITED 02151600108 13062666369 info@isotopechem.com China 4721 58
Hubei Moco Chemical Co., Ltd. 18627753421; 18627756402 3001051413@qq.com China 20013 58
Supplier Advantage
Jinan blalong chemical co. LTD 58
CHINA ISOTOPE CO., LIMITED 58
Hubei Moco Chemical Co., Ltd. 58

321125-94-4(5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one)Related Search:

(S)-2-((R)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-4-benzylMorpholin-3-one 1,1,1-Trimethoxy-2-chloroethane (R,R,R)-Aprepitant Aprepitant Aprepitant
(2S,3R)-2-((S)-1-(3,5-bis(trifluoroMethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine Fosaprepitant Benzyl dihydrogen phosphate (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine (2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(phenyl)Morpholine hydrochloride
(2R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-5,6-dihydro-2H-1,4-oxazine Aprepitant Impurity 6 Aprepitant Defluoro Aprepitant Aprepitant Impurity 17
(1S,2S,3R)-Aprepitant Aprepitant Impurity B HCl Aprepitant Impurity 11 HCl

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rac-Aprepitant-d4 3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-, rel- 5-[[(2S,3R)-2-[(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one 321125-94-4