3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 473923-56-7
- Chemical Name:
- 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate;N-BOC-3-hydroxymethylmorpholine;4-BOC-3-HYDROXYMETHYL-MORPHOLINE;1-N-BOC-2-HYDROXYMETHYL MORPHOLINE;Di-tert-butyl morpholine-3,4-dicarboxylate;3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate - [B23806];4-Morpholinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester
- CBNumber:
- CB51517209
- Molecular Formula:
- C10H19NO4
- Molecular Weight:
- 217.26
- MDL Number:
- MFCD04038649
- MOL File:
- 473923-56-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Boc-(3-Hydroxymethyl)morpholine | 076262 | 1.00g | $578 |
| 4-Boc-(3-Hydroxymethyl)morpholine | 076262 | 5.00g | $1498 |
| 4-Boc-(3-Hydroxymethyl)morpholine | 076262 | 10.00g | $2233 |
| tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate 97% | B23806 | 5g | $80 |
| tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate 97% | B23806 | 10g | $150 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 076262 | 4-Boc-(3-Hydroxymethyl)morpholine | 473923-56-7 | 1.00g | $578 | 2026-05-18 | Buy |
| Matrix Scientific | 076262 | 4-Boc-(3-Hydroxymethyl)morpholine | 473923-56-7 | 5.00g | $1498 | 2026-05-18 | Buy |
| Matrix Scientific | 076262 | 4-Boc-(3-Hydroxymethyl)morpholine | 473923-56-7 | 10.00g | $2233 | 2026-05-18 | Buy |
| Synthonix | B23806 | tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate 97% | 473923-56-7 | 5g | $80 | 2026-05-06 | Buy |
| Synthonix | B23806 | tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate 97% | 473923-56-7 | 10g | $150 | 2026-05-06 | Buy |
3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production
Uses
3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER can be used in pharmaceutical synthesis and organic synthesis experiments.
Synthesis
212650-43-6
473923-56-7
Step L (1): synthesis of tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate. To a solution of tetrahydrofuran (THF, 120 mL) of 4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid (4.7 g, 20.35 mmol) was added sequentially Hunig base (6.6 g, 50.875 mmol) and ethyl chloroformate (2.65 g, 24.4 mmol) at 0 °C. The reaction mixture was stirred at 0 °C to room temperature for 1.5 h. Sodium borohydride (NaBH4, 3.1 g, 81.4 mmol) was added. after 15 min, methanol (MeOH, 20 mL) was slowly added. The reaction mixture was continued to be stirred for 1 h at room temperature. Subsequently, THF and MeOH were removed under reduced pressure and diluted by adding ethyl acetate (600 mL). The organic phase was washed sequentially with saturated sodium bicarbonate (NaHCO3) solution and water, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. 3.56 g of the target product tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate was obtained in 81% yield. The product was characterized by 1H NMR (CDCl3, 500 MHz): δ 1.46 (9H, s), 2.03 (1H, br s), 3.17 (1H, m), 3.46 (1H, m), 3.56 (1H, m), 3.72-3.86 (4H, m), 3.91 (1H, d, J = 10 Hz), 3.99 (1H, br s).
References
[1] Patent: US2006/46984, 2006, A1. Location in patent: Page/Page column 25-26
[2] Patent: WO2006/99352, 2006, A1. Location in patent: Page/Page column 35-36
[3] Patent: WO2013/91773, 2013, A1. Location in patent: Page/Page column 130; 131
[4] Patent: US2010/261701, 2010, A1. Location in patent: Page/Page column 144
[5] Patent: WO2008/125570, 2008, A1
3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5973 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8645 | 58 |
View Lastest Price from 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-04 | 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
473923-56-7
|
$5.00 | 1KG | 95%-98% | 100kg | Career Henan Chemical Co |
-
- 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
473923-56-7
- $5.00
- 95%-98%
- Career Henan Chemical Co
473923-56-7(3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER)Related Search:
1of4
