Diethylaminosulfur trifluoride
- CAS No.
- 38078-09-0
- Chemical Name:
- Diethylaminosulfur trifluoride
- Synonyms
- DAST;ET2NSF3;DIETHYLAMINOSULPHUR TRIFLUORIDE;(diethylamino)trifluorosulfur;Diethylamine sulfur trifluoride;(N,N-diethylamino)sulfurtrifluoride;amino)suL;fur trifL;(beta-4)-sulfu;(T-4)-(N-ethyl
- CBNumber:
- CB5153161
- Molecular Formula:
- C4H10F3NS
- Molecular Weight:
- 161.19
- MDL Number:
- MFCD00000363
- MOL File:
- 38078-09-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| (Diethylamino)sulfur trifluoride | 235253 | 1g | $48.9 |
| (Diethylamino)sulfur trifluoride | 235253 | 5g | $114 |
| (Diethylamino)sulfur Trifluoride [Fluorinating Reagent] >90.0%(T) | D1868 | 5g | $102 |
| (Diethylamino)sulfur Trifluoride [Fluorinating Reagent] >90.0%(T) | D1868 | 25g | $323 |
| Diethylaminosulfur trifluoride | 270703 | 25g | $648 |
| More product size | |||
| Boiling point | 30-32 °C3 mm Hg(lit.) |
|---|---|
| Density | 1.22 g/mL at 25 °C(lit.) |
| refractive index | 1.41-1.416 |
| Flash point | 75 °F |
| storage temp. | 2-8°C |
| solubility | Benzene, Chloroform (Slightly) |
| form | liquid |
| pka | -4.87±0.70(Predicted) |
| color | Colorless to Yellow to Orange |
| Specific Gravity | 1.220 |
| Water Solubility | decomposes |
| Sensitive | Moisture Sensitive |
| Merck | 14,3113 |
| BRN | 1849066 |
| Exposure limits |
ACGIH: TWA 2.5 mg/m3 NIOSH: IDLH 250 mg/m3 |
| Stability | Reacts with Moisture in the Air, Reacts With Moisture In The Air, Unstable in So |
| InChI | 1S/C4H10F3NS/c1-3-8(4-2)9(5,6)7/h3-4H2,1-2H3 |
| InChIKey | CSJLBAMHHLJAAS-UHFFFAOYSA-N |
| SMILES | CCN(CC)S(F)(F)F |
| CAS DataBase Reference | 38078-09-0(CAS DataBase Reference) |
| FDA UNII | 78622BV6IJ |
| NIST Chemistry Reference | Diethylaminosulfur trifluoride(38078-09-0) |
| UNSPSC Code | 12352101 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H242-H314 | |||||||||
| Precautionary statements | P210-P280-P303+P361+P353-P305+P351+P338-P370+P378-P403+P235 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C,T,F | |||||||||
| Risk Statements | 10-14-20/21/22-34-5-35-40 | |||||||||
| Safety Statements | 16-26-36/37/39-45 | |||||||||
| RIDADR | UN 2920 8/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10-21 | |||||||||
| Hazard Note | Corrosive/Keep Cold | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29309070 | |||||||||
| Storage Class | 5.2 - Organic peroxides and self-reacting hazardous materials | |||||||||
| Hazard Classifications | Eye Dam. 1 Flam. Liq. 3 Self-react. D Skin Corr. 1A |
|||||||||
| Excepted Quantities | Not Permitted as Excepted Quantity | |||||||||
| NFPA 704 |
|
Diethylaminosulfur trifluoride price More Price(84)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 235253 | (Diethylamino)sulfur trifluoride | 38078-09-0 | 1g | $48.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | 235253 | (Diethylamino)sulfur trifluoride | 38078-09-0 | 5g | $114 | 2026-04-30 | Buy |
| TCI Chemical | D1868 | (Diethylamino)sulfur Trifluoride [Fluorinating Reagent] >90.0%(T) | 38078-09-0 | 5g | $102 | 2026-04-30 | Buy |
| TCI Chemical | D1868 | (Diethylamino)sulfur Trifluoride [Fluorinating Reagent] >90.0%(T) | 38078-09-0 | 25g | $323 | 2026-04-30 | Buy |
| Usbiological | 270703 | Diethylaminosulfur trifluoride | 38078-09-0 | 25g | $648 | 2026-06-03 | Buy |
Diethylaminosulfur trifluoride Chemical Properties,Uses,Production
Fluorinating reagents
N,N-Diethylaminosulfur trifluoride (DAST) is the most widely used fluorinating reagent in this class. It has a similar reactivity to sulfur tetrafluoride, but has the advantage that it can be used in glass vessels at atmospheric pressure. Deoxofluorination reactions with N,N-diethylaminosulfur trifluoride are usually run neat or in anhydrous aprotic solvents, most frequently halogenated solvents, at temperatures of 0- 80 °C. Typically, a stoichiometric amount of the reagent is used for aldehydes and a small excess is used for ketones.
Diethylaminosulfur trifluoride is the most widely used member of this family of reagents, is a pale yellow liquid that reacts violently with water. DAST is readily obtained from commercial sources (e.g. Aldrich or Lancaster) and can also be prepared by the reaction of N,N-di-ethylaminotrimethylsilane with sulfur tetrafluoride, followed by distillation of the crude product under reduced pressure. DAST is known to be thermally unstable, undergoing either explosion or detonation when heated to > 9°ºC.
Preparation
This preparation of diethylaminosulfur trifluoride is an adaptation of a procedure first described by von Halasz and Glemser.The same procedure can also be used to prepare other dialkylaminosulfur trifluorides by the substitution of the diethylaminotrimethylsilane with other dialkylaminotrimethylsilanes.
A solution of 96 g (0.66 mole) of diethylaminotrimethylsilane in 100 ml trichlorofluoromethane was added dropwise to a solution of 40 ml (measured at -78°, 0.72 mole) of sulfur tetrafluoride in 200 ml of trichlorofluoromethane at -65° to -60°. The reaction mixture was warmed to room temperature and then distilled to give 88.86 g (84% yield) of diethylaminosulfur trifluoride as a pale yellow liquid, bp 46°-47° (10 mm).
Reactions
Diethylaminosulfur trifluoride (DAST) has proven itself to be an extremely popular reagent for nucleophilic fluorination, due to its ease of handling and versatility. It has regularly been employed in a myriad selective fluorinations of alcohols, alkenols, carbohydrates, ketones, sulfides, epoxides, thioethers, and cyanohydrins. In addition some novel organic cyclizations are possible when DAST is employed as a reagent.
Fluorodeoxygenation was achieved using DAST in a preparatively simple synthesis of 5,5-difluoropipecolic acid from glutamic acid.
1,2,2-Trifluorostyrenes can be synthesized using a sequential reaction on the parent a-(trifluoromethyl)phenylethanol with DAST, followed by dehydrohalogenation with lithium bis(trimethylsilyl)amide (LHMDS). This method achieves the trifluorostyrene without requirement of palladium coupling.
DAST was recently used to obtain fluorinated analogues of 3,6-dibromocarbazole piperazine derivatives of 2-propanol (Scheme 7). A series of these analogues are described as the first small and potent modulators of the cytochrome c release triggered by Bid-induced Bax activation in a mitochondrial assay.
Precautions
diethylaminosulfur trifluoride (DAST) reacts violently with water, it is volatile, and is reported to be explosive when heated owing to its calorimetry profile and its rapid dismutation to SF4 and (Et2N)2SF2. Furthermore, its decomposition products are themselves highly reactive and will etch laboratory glassware. Accordingly, DAST must be used with extreme caution, and samples are recommended not to be heated above 90 °C.
Chemical Properties
Pale yellow liquid. Soluble in most non-polar organic solvents, commonly used in CH2Cl2, CHCl3 and CCl4.
Uses
Diethylaminosulfur Trifluoride is a very useful Nucleophilic fluorinating agent in chemical synthesis. It is also used as a reagent in the preparation of 2-thiazolines from (1,2)-thioam ido-alcohols.
Application
Diethylaminosulfur trifluoride (DAST) is used as a precursor to prepare 2,6-dimethoxybenzoyl fluoride and 2-thiazolines. It is a useful fluorinating agent used for a variety of compounds including alcohols, thioethers, alkenols and cyanohydrins. It also serves as a catalyst for Friedel-Crafts allylation reaction using tertiary cyclopropyl silyl ethers and in the rearrangement of homoallylic alcohols to unsaturated aldehydes. It plays an important role for gem difluorination of ketopipecolinic acids.
Diethylaminosulfur trifluoride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | banny.janga@btcpharm.com | India | 1262 | 58 |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 8741 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49969 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21587 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
Related articles
- The uses of Diethylaminosulfur trifluoride
- Diethylaminosulfur trifluoride is a useful and convenient reagent for replacing primary, secondary, and tertiary hydroxyl and ....
- Sep 25，2019
View Lastest Price from Diethylaminosulfur trifluoride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-15 | Diethylaminosulfur trifluoride
38078-09-0
|
$780.00 | 1KG | 98% | 1-10mt | Baoji Guokang Healthchem Co., Ltd. | |
 |
2025-06-27 | Diethylaminosulfur trifluoride
38078-09-0
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2025-06-20 | Diethylaminosulfur trifluoride
38078-09-0
|
$50.00-80.00 | 1kgkg | 0.99 | 1000 | Hebei Yanxi Chemical Co., Ltd. |
-
- Diethylaminosulfur trifluoride
38078-09-0
- $780.00
- 98%
- Baoji Guokang Healthchem Co., Ltd.
-
- Diethylaminosulfur trifluoride
38078-09-0
- $0.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Diethylaminosulfur trifluoride
38078-09-0
- $50.00-80.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
