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2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE

2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE structure

CAS No.: 456-00-8

Chemical Name:: 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE

Synonyms: 2-Amino-4-fluoroacetophenone hcl;2-Amino-4'-fluoroacetophenone, HCl;4-FLUOROPHENACYLAMINE HYDROCHLORIDE;2-(4-FLUORO-PHENYL)-2-OXO-ETHYL-AMMONIUM;2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE;[2-(4-fluorophenyl)-2-oxoethyl]azanium chloride;[2-(4-fluorophenyl)-2-oxo-ethyl]azanium chloride;[2-(4-fluorophenyl)-2-keto-ethyl]ammonium chloride;2-(4-FLUORO-PHENYL)-2-OXO-ETHYL-AMMONIUM, CHLORIDE;2-AMINO-1-(4-FLUORO-PHENYL)-ETHANONE HYDROCHLORIDE

CBNumber:: CB5172155

Molecular Formula:: C8H9ClFNO

Molecular Weight:: 189.61

MDL Number:: MFCD00193059

MOL File:: 456-00-8.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:49

Product description	Number	Pack Size	Price
2-Amino-1-(4-fluorophenyl)ethanoneHydrochloride	A630560	100mg	$60
2-Amino-4'-fluoroacetophenonehydrochloride	J93916	1g	$30
4-Fluorophenacylaminehydrochloride 95%	PC4576	1g	$35
4-Fluorophenacylamine hydrochloride 95%	4656-7-05	1g	$39
2-Amino-4'-fluoroacetophenone hydrochloride	FA70081	5G	$50
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2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE Properties

Melting point	235-238
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	crystalline needles
color	White
InChI	InChI=1S/C8H8FNO.ClH/c9-7-3-1-6(2-4-7)8(11)5-10;/h1-4H,5,10H2;1H
InChIKey	KQROOJFZQSQJMM-UHFFFAOYSA-N
SMILES	C(C1=CC=C(F)C=C1)(=O)CN.[H]Cl
CAS DataBase Reference	456-00-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes	Xi,Xn
Risk Statements	22
HazardClass	IRRITANT
HS Code	2922390090

2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A630560	2-Amino-1-(4-fluorophenyl)ethanoneHydrochloride	456-00-8	100mg	$60	2021-12-16	Buy
AK Scientific	J93916	2-Amino-4'-fluoroacetophenonehydrochloride	456-00-8	1g	$30	2021-12-16	Buy
Apolloscientific	PC4576	4-Fluorophenacylaminehydrochloride 95%	456-00-8	1g	$35	2021-12-16	Buy
SynQuest Laboratories	4656-7-05	4-Fluorophenacylamine hydrochloride 95%	456-00-8	1g	$39	2021-12-16	Buy
Biosynth Carbosynth	FA70081	2-Amino-4'-fluoroacetophenone hydrochloride	456-00-8	5G	$50	2021-12-16	Buy

Product number	Packaging	Price	Buy
A630560	100mg	$60	Buy
J93916	1g	$30	Buy
PC4576	1g	$35	Buy
4656-7-05	1g	$39	Buy
FA70081	5G	$50	Buy

2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE Chemical Properties,Uses,Production

Synthesis

403-29-2

2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE

456-00-8

The general procedure for the synthesis of α-amino-p-fluoroacetophenone hydrochloride from 2-bromo-4'-fluoroacetophenone was as follows: Intermediate 5A was prepared by the method described in PCT Publication No. WO 2009/137081 (PCT US2009/002845), which was carried out as follows: To a solution of chloroform (65.5 mL) containing 2-bromo-1-(4-fluorophenyl)ethanone (6.57 g, 30.3 mmol) Hexamethylenetetramine (4.37 g, 30.8 mmol) was added to a solution of chloroform (65.5 mL) containing 2-bromo-1-(4-fluorophenyl)ethanone (6.57 g, 30.3 mmol). The reaction mixture was stirred at room temperature for 16 hours and then filtered to collect a white solid. The solid was suspended in methanol (130 mL) followed by the slow addition of concentrated hydrochloric acid (~8.6 mL). The resulting homogeneous reaction mixture was refluxed for 4 hours. Upon completion of the reaction, the mixture was cooled, filtered to remove the inorganic salt, and the filter cake was washed with methanol (~30 mL). The filtrates were combined and concentrated under reduced pressure to give a solid product, which was then dried under high vacuum for 2 hours. Further purification by silica gel column chromatography (using a Thomson BIOTAGE column eluting with a gradient of 5% to 20% dichloromethane solution in methanol) gave a red solid product. The solid was dissolved in a small amount of dichloromethane and filtered to give Intermediate 5A as a colorless solid (5.44 g, 95% yield).HPLC retention time: 0.90 min (Method D). Mass spectrum (electrospray ionization): m/z = 136.05 [M + H]+.

References

[1] Patent: WO2014/100533, 2014, A1. Location in patent: Page/Page column 72; 73
[2] Patent: US2018/297990, 2018, A1. Location in patent: Paragraph 0244
[3] Journal of Medicinal Chemistry, 1982, vol. 25, # 9, p. 1045 - 1050
[4] Synlett, 2004, # 11, p. 2031 - 2033
[5] Chemical and Pharmaceutical Bulletin, 2015, vol. 63, # 8, p. 628 - 635

2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

2-Bromo-4'-fluoroacetophenone 2-azido-1-(4-fluorophenyl)ethan-1-one 3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane, 1-[2-(4-fluorophenyl)-2-oxoethyl]-, bromide (1:1) Hexamethylenetetramine Methanol

Hydrochloric acid Chloroform Water

1of2

Preparation Products

1,3-dihydro-4-(4-fluorophenyl)-2h-imidazole-2-thione

2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE Suppliers

Global( 120)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30229	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14343	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Fluoropharm Co., Ltd.	60
Changzhou Ansciep Chemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-22	2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE 456-00-8	US $1.30 / g	1g	98%	10kg	Career Henan Chemica Co

2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE
456-00-8
US $1.30 / g
98%
Career Henan Chemica Co

2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE Spectrum

2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE(456-00-8)¹HNMR 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE(456-00-8)¹⁹FNMR

456-00-8(2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE)Related Search:

4-Fluoroacetophenone α-Amino-4’-fluoroacetophenone hydrochloride,a-Amino-4-fluoroacetophenone hydrochloride 2-AMINO-3'-FLUOROACETOPHENONE HYDROCHLORIDE

4-FLUOROPHENACYLAMINE HYDROCHLORIDE 2-(4-FLUORO-PHENYL)-2-OXO-ETHYL-AMMONIUM, CHLORIDE 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE 2-AMINO-1-(4-FLUOROPHENYL)-1-ETHANONE HYDROCHLORIDE 2-AMINO-1-(4-FLUORO-PHENYL)-ETHANONE HYDROCHLORIDE 2-(4-FLUORO-PHENYL)-2-OXO-ETHYL-AMMONIUM 2-Amino-4-fluoroacetophenone hcl 2-Amino-1-(4-fluorophenyl)ethan-1-one hydrochloride, 2-Amino-4'-fluoroacetophenone hydrochloride 2-aMino-1-(4-fluorophenyl)ethan-1-one hydrochloride Ethanone, 2-amino-1-(4-fluorophenyl)-, hydrochloride (1:1) [2-(4-fluorophenyl)-2-keto-ethyl]ammonium chloride [2-(4-fluorophenyl)-2-oxoethyl]azanium chloride [2-(4-fluorophenyl)-2-oxo-ethyl]azanium chloride Ethanone, 2-amino-1-(4-fluorophenyl)-, hydrochloride 2-Amino-4'-fluoroacetophenone, HCl 456-00-8 C8H8NOF C8H8FNOHCl C8H9ClFNO Aromatic Acetophenones & Derivatives (substituted)