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2-Amino-4'-fluoroacetophenone hydrochloride

2-Amino-4'-fluoroacetophenone hydrochloride Structure
2-Amino-4'-fluoroacetophenone hydrochloride structure
CAS No.
456-00-8
Chemical Name:
2-Amino-4'-fluoroacetophenone hydrochloride
Synonyms
2-Amino-4-fluoroacetophenone hcl;2-Amino-4'-fluoroacetophenone, HCl;4-FLUOROPHENACYLAMINE HYDROCHLORIDE;2-(4-FLUORO-PHENYL)-2-OXO-ETHYL-AMMONIUM;2-Amino-4'-fluoroacetophenone hydrochloride;[2-(4-fluorophenyl)-2-oxoethyl]azanium chloride;[2-(4-fluorophenyl)-2-oxo-ethyl]azanium chloride;[2-(4-fluorophenyl)-2-keto-ethyl]ammonium chloride;2-(4-FLUORO-PHENYL)-2-OXO-ETHYL-AMMONIUM, CHLORIDE;2-AMINO-1-(4-FLUORO-PHENYL)-ETHANONE HYDROCHLORIDE
CBNumber:
CB5172155
Molecular Formula:
C8H9ClFNO
Molecular Weight:
189.61
MDL Number:
MFCD00193059
MOL File:
456-00-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:53:17
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2-Amino-4'-fluoroacetophenone hydrochloride Properties

Melting point 235-238
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form crystalline needles
color White
InChI InChI=1S/C8H8FNO.ClH/c9-7-3-1-6(2-4-7)8(11)5-10;/h1-4H,5,10H2;1H
InChIKey KQROOJFZQSQJMM-UHFFFAOYSA-N
SMILES C(C1=CC=C(F)C=C1)(=O)CN.[H]Cl
CAS DataBase Reference 456-00-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  Xi,Xn
Risk Statements  22
HazardClass  IRRITANT
HS Code  2922390090

2-Amino-4'-fluoroacetophenone hydrochloride price More Price(61)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC4576 4-Fluorophenacylamine hydrochloride 95% 456-00-8 1g $21 2026-06-04 Buy
Activate Scientific AS32155 2-Amino-1-(4-fluorophenyl)ethanone hydrochloride 97% 456-00-8 1g $28 2026-06-04 Buy
Activate Scientific AS32155 2-Amino-1-(4-fluorophenyl)ethanone hydrochloride 97% 456-00-8 5g $77 2026-06-04 Buy
Activate Scientific AS32155 2-Amino-1-(4-fluorophenyl)ethanone hydrochloride 97% 456-00-8 25g $305 2026-06-04 Buy
AK Scientific L174 2-Amino-4'-fluoroacetophenone hydrochloride >98%(HPLC) 456-00-8 250mg $16 2026-06-04 Buy
Product number Packaging Price Buy
PC4576 1g $21 Buy
AS32155 1g $28 Buy
AS32155 5g $77 Buy
AS32155 25g $305 Buy
L174 250mg $16 Buy

2-Amino-4'-fluoroacetophenone hydrochloride Chemical Properties,Uses,Production

Synthesis

2-Bromo-4'-fluoroacetophenone

403-29-2

2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE

456-00-8

The general procedure for the synthesis of α-amino-p-fluoroacetophenone hydrochloride from 2-bromo-4'-fluoroacetophenone was as follows: Intermediate 5A was prepared by the method described in PCT Publication No. WO 2009/137081 (PCT US2009/002845), which was carried out as follows: To a solution of chloroform (65.5 mL) containing 2-bromo-1-(4-fluorophenyl)ethanone (6.57 g, 30.3 mmol) Hexamethylenetetramine (4.37 g, 30.8 mmol) was added to a solution of chloroform (65.5 mL) containing 2-bromo-1-(4-fluorophenyl)ethanone (6.57 g, 30.3 mmol). The reaction mixture was stirred at room temperature for 16 hours and then filtered to collect a white solid. The solid was suspended in methanol (130 mL) followed by the slow addition of concentrated hydrochloric acid (~8.6 mL). The resulting homogeneous reaction mixture was refluxed for 4 hours. Upon completion of the reaction, the mixture was cooled, filtered to remove the inorganic salt, and the filter cake was washed with methanol (~30 mL). The filtrates were combined and concentrated under reduced pressure to give a solid product, which was then dried under high vacuum for 2 hours. Further purification by silica gel column chromatography (using a Thomson BIOTAGE column eluting with a gradient of 5% to 20% dichloromethane solution in methanol) gave a red solid product. The solid was dissolved in a small amount of dichloromethane and filtered to give Intermediate 5A as a colorless solid (5.44 g, 95% yield).HPLC retention time: 0.90 min (Method D). Mass spectrum (electrospray ionization): m/z = 136.05 [M + H]+.

References

[1] Patent: WO2014/100533, 2014, A1. Location in patent: Page/Page column 72; 73
[2] Patent: US2018/297990, 2018, A1. Location in patent: Paragraph 0244
[3] Journal of Medicinal Chemistry, 1982, vol. 25, # 9, p. 1045 - 1050
[4] Synlett, 2004, # 11, p. 2031 - 2033
[5] Chemical and Pharmaceutical Bulletin, 2015, vol. 63, # 8, p. 628 - 635

2-Amino-4'-fluoroacetophenone hydrochloride Preparation Products And Raw materials

Raw materials

2-Bromo-4'-fluoroacetophenone 2-azido-1-(4-fluorophenyl)ethan-1-one 3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane, 1-[2-(4-fluorophenyl)-2-oxoethyl]-, bromide (1:1) Hexamethylenetetramine Methanol
Hydrochloric acid Chloroform Water

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Preparation Products

1,3-dihydro-4-(4-fluorophenyl)-2h-imidazole-2-thione

2-Amino-4'-fluoroacetophenone hydrochloride Suppliers

Global( 124)Suppliers
Supplier Tel Email Country ProdList Advantage
Hotechem Shanghai Co., Ltd., 021-34621078 13120882795 465106944@qq.com China 859 56
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Nanjing Norris-Pharm Technology Co., Ltd 13901585132 sales@norris-pharm.com China 8869 55
Supplier Advantage
Hotechem Shanghai Co., Ltd., 56
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Pure Chemistry Scientific Inc. 62
Adamas Reagent, Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57
Shanghai Topbiochem Technology Co., Ltd 58
Nanjing Norris-Pharm Technology Co., Ltd 55

View Lastest Price from 2-Amino-4'-fluoroacetophenone hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE pictures 2024-10-22 2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE
456-00-8
 $1.30 1g 98% 10kg Career Henan Chemica Co

2-Amino-4'-fluoroacetophenone hydrochloride Spectrum

2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE(456-00-8)1HNMR2-AMINO-4'-FLUOROACETOPHENONE HYDROCHLORIDE(456-00-8)19FNMR

456-00-8(2-Amino-4'-fluoroacetophenone hydrochloride)Related Search:

2-Amino-3'-fluoroacetophenone hydrochloride 4-Fluoroacetophenone α-Amino-4’-fluoroacetophenone hydrochloride,a-Amino-4-fluoroacetophenone hydrochloride [2-(4-FLUORO-PHENYL)-2-OXO-ETHYL]-CARBAMIC ACID TERT-BUTYL ESTER Benzenemethanol, alpha-(aminomethyl)-4-fluoro-, (alphaS)- (9CI)
2-Hydroxy-2-(4-fluorophenyl)ethylamine hydrochloride

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4-FLUOROPHENACYLAMINE HYDROCHLORIDE 2-(4-FLUORO-PHENYL)-2-OXO-ETHYL-AMMONIUM, CHLORIDE 2-AMINO-1-(4-FLUOROPHENYL)-1-ETHANONE HYDROCHLORIDE 2-AMINO-1-(4-FLUORO-PHENYL)-ETHANONE HYDROCHLORIDE 2-(4-FLUORO-PHENYL)-2-OXO-ETHYL-AMMONIUM 2-Amino-4-fluoroacetophenone hcl 2-Amino-1-(4-fluorophenyl)ethan-1-one hydrochloride, 2-Amino-4'-fluoroacetophenone hydrochloride 2-aMino-1-(4-fluorophenyl)ethan-1-one hydrochloride Ethanone, 2-amino-1-(4-fluorophenyl)-, hydrochloride (1:1) [2-(4-fluorophenyl)-2-keto-ethyl]ammonium chloride [2-(4-fluorophenyl)-2-oxoethyl]azanium chloride [2-(4-fluorophenyl)-2-oxo-ethyl]azanium chloride Ethanone, 2-amino-1-(4-fluorophenyl)-, hydrochloride 2-Amino-4'-fluoroacetophenone, HCl 2-Amino-4'-fluoroacetophenone hydrochloride 456-00-8 C8H8NOF C8H8FNOHCl C8H9ClFNO Aromatic Acetophenones & Derivatives (substituted)