ChemicalBook >> CAS DataBase List >>(-)-LEUKOTRIENE A4 METHYL ESTER

(-)-LEUKOTRIENE A4 METHYL ESTER

CAS No.
73466-12-3
Chemical Name:
(-)-LEUKOTRIENE A4 METHYL ESTER
Synonyms
(-)-leukotriene A4;PWXYNAKNLZUYAL-WAQVJNLQSA-N;LEUKOTRIENE A4 METHYL ESTER;(-)-LEUKOTRIENE A4 METHYL ESTER;LTA4 (Leukotriene A4 methyl ester);5S-TRANS-5,6-OXIDO-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID, METHYL ESTER;LEUKOTRIENE A4-METHYLESTER SOLUTION (100UG/ML HEXANE/1% TRIETHYLAMINE);14,15-Leukotriene A4 methyl ester, Inhibitor of Leukotriene A4 hydrolase;Leukotriene A4 methyl ester, Leukotriene B3 and Leukotriene B4 precursor;2-Oxiranebutanoic acid, 3-(1E,3E,5Z,8Z)-1,3,5,8-tetradecatetraen-1-yl-, methyl ester, (2S,3S)-
CBNumber:
CB5184743
Molecular Formula:
C21H32O3
Molecular Weight:
332.48
MDL Number:
MFCD00065847
MOL File:
73466-12-3.mol
Last updated:2026-01-05 15:21:26
Product description Number Pack Size Price
Leukotriene A4 methyl ester ≥97% 20010 25μg $144
Leukotriene A4 methyl ester ≥97% 20010 50μg $274
Leukotriene A4 methyl ester ≥97% 20010 100μg $519
Leukotriene A4 methyl ester ≥97% 20010 500μg $1579
Leukotriene A4 366268 96Tests $938

(-)-LEUKOTRIENE A4 METHYL ESTER Properties

storage temp. −20°C
solubility Acetone: >50 mg/ml; DMF: >50 mg/ml; DMSO: >50 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: insoluble and unstable.
form triethylamine:hexane solution
FDA UNII 7Y7MPZ6563
UNSPSC Code 12352211
NACRES NA.25

(-)-LEUKOTRIENE A4 METHYL ESTER price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 20010 Leukotriene A4 methyl ester ≥97% 73466-12-3 25μg $144 2024-03-01 Buy
Cayman Chemical 20010 Leukotriene A4 methyl ester ≥97% 73466-12-3 50μg $274 2024-03-01 Buy
Cayman Chemical 20010 Leukotriene A4 methyl ester ≥97% 73466-12-3 100μg $519 2024-03-01 Buy
Cayman Chemical 20010 Leukotriene A4 methyl ester ≥97% 73466-12-3 500μg $1579 2023-06-20 Buy
Usbiological 366268 Leukotriene A4 73466-12-3 96Tests $938 2021-12-16 Buy
Product number Packaging Price Buy
20010 25μg $144 Buy
20010 50μg $274 Buy
20010 100μg $519 Buy
20010 500μg $1579 Buy
366268 96Tests $938 Buy

(-)-LEUKOTRIENE A4 METHYL ESTER Chemical Properties,Uses,Production

Description

Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.

Uses

LTA4 (Leukotriene A4 methyl ester) is an unstable intermediate in the biosynthesis of LTB4 and LTC4.

References

[1] T SHIMIZU  B S  O R?dmark. Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1984, 81 3: 689-693. DOI: 10.1073/pnas.81.3.689
[2] BENGT SAMUELSSON. Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects[J]. Science, 1987, 237 4819. DOI: 10.1126/science.2820055
[3] J A MACLOUF  R C M. Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential cellular source of leukotriene C4.[J]. The Journal of Biological Chemistry, 1988, 263 1: 174-181.

73958-00-6
73958-09-5
73466-12-3
Synthesis of (-)-LEUKOTRIENE A4 METHYL ESTER from METHYL-(5S,6S)-EPOXY-11-OXO-(7E,9E)-UNDECADIENOATE and Phosphorane, (3Z)-3-nonen-1-ylidenetriphenyl-

(-)-LEUKOTRIENE A4 METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-LEUKOTRIENE A4 METHYL ESTER Suppliers

Global( 43)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32470 58
Aladdin Scientific
tp@aladdinsci.com United States 52923 58
Shanghai Macklin Biochemical Co.,Ltd. 15221275939 shenlinxing@macklin.cn China 15872 55
Alfa Chemistry 1-516-6625404 support@alfa-chemistry.com United States 9171 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
amyjet 4006800868;027-59626688 18371453821;18771149750 ework@amyjet.com;sales@amyjet.com China 2917 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24961 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7982 58
Cayman Chemical Company 800-364-9897 sales@caymanchem.com China 6838 58

View Lastest Price from (-)-LEUKOTRIENE A4 METHYL ESTER manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Leukotriene A4 methyl ester pictures 2026-01-05 Leukotriene A4 methyl ester
73466-12-3
US $1870.00 / μg 10g TargetMol Chemicals Inc.
(-)-LEUKOTRIENE A4 METHYL ESTER LEUKOTRIENE A4 METHYL ESTER (-)-leukotriene A4 LEUKOTRIENE A4-METHYLESTER SOLUTION (100UG/ML HEXANE/1% TRIETHYLAMINE) LTA4 (Leukotriene A4 methyl ester) PWXYNAKNLZUYAL-WAQVJNLQSA-N 5S-TRANS-5,6-OXIDO-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID, METHYL ESTER 2-Oxiranebutanoic acid, 3-(1E,3E,5Z,8Z)-1,3,5,8-tetradecatetraen-1-yl-, methyl ester, (2S,3S)- Leukotriene A4 methyl ester, Leukotriene B3 and Leukotriene B4 precursor 14,15-Leukotriene A4 methyl ester, Inhibitor of Leukotriene A4 hydrolase 73466-12-3 Biochemicals and Reagents BioChemical Unsaturated fatty acids and derivatives Esters Fatty Acids Methyl Esters Lipids