Thiostrepton | 1393-48-2

Thiostrepton Properties

Melting point	248-257°C (dec.)
alpha	D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)
Density	1.0824 (rough estimate)
refractive index	1.6700 (estimate)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in DMSO or chloroform
form	Off-white powder
pka	10.43±0.46(Predicted)
color	Off-white
Water Solubility	0.24g/L(28 ºC)
Merck	13,9440
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChIKey	NSFFHOGKXHRQEW-MRQRIGNGNA-N
EWG's Food Scores	1
FDA UNII	HR4S203Y18
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332

Precautionary statements

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

3

RTECS

XN6300100

F

10-21

HS Code

29419090

Storage Class

11 - Combustible Solids

Toxicity

LD50 oral in mouse: > 1gm/kg

NFPA 704

	0
2		0

Thiostrepton price More Price(60)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	598226	Thiostrepton - CAS 1393-48-2 - Calbiochem Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit.	1393-48-2	1g	$151	2026-04-30	Buy
Sigma-Aldrich	598226	Thiostrepton - CAS 1393-48-2 - Calbiochem Thiostrepton, CAS 1393-48-2, is an antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit.	1393-48-2	10g	$1120	2026-04-30	Buy
Cayman Chemical	19200	Thiostrepton ≥95%	1393-48-2	500mg	$76	2026-04-30	Buy
Cayman Chemical	19200	Thiostrepton ≥95%	1393-48-2	1g	$115	2026-04-30	Buy
Cayman Chemical	19200	Thiostrepton ≥95%	1393-48-2	5g	$494	2026-04-30	Buy

Product number	Packaging	Price	Buy
598226	1g	$151	Buy
598226	10g	$1120	Buy
19200	500mg	$76	Buy
19200	1g	$115	Buy
19200	5g	$494	Buy

Thiostrepton Chemical Properties, Uses, Production

Description

The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G₁ phase, with expression continuing through S phase and mitosis. Thiostrepton is a natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, thiostrepton prevents proliferation and induces apoptosis in human cancer cells. These effects correlate with the ability of thiostrepton to act as a proteasome inhibitor.

Chemical Properties

Off-White Solid

Uses

beta-adrenergic agonist

Uses

Thiostrepton is a macrocyclic antibiotic incorporating thiazoles and other atypical amino acids. Patented in 1961, thiostrepton has been used as an antibiotic and acts by binding to ribosomes to prevent the binding of the EF-G elongation factor and GTP to the 50S ribosomal subunit. Thiostrepton is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, that are central regulators in multidrug resistance. Thiostrepton is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

Uses

A protein synthesis-inhibiting antibiotic

Uses

Natural antibiotic derived from Streptomyces.

Definition

ChEBI: A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitu or agent.

General Description

A thiazole-containing peptide antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit. Inhibits the function of elongation factor G (EF-G) and the dissociation of EF-G from the ribosome. The thiostrepton-resistant gene is also commonly used as a selective marker for recombinant DNA/plasmid technologies.

Biochem/physiol Actions

Primary TargetEF-G

in vitro

thiostrepton inhibits the transcriptional activity and foxm1 expression, and induces strong apoptosis in human cancer cells of different origin that correlates with suppression of foxm1, including leukemia, neuroblastoma, liver cancer, melanoma and prostate cancer cells. thiostrepton binds foxm1 on the promoter site to inhibit transcriptional activity of foxm1 through the foxm1 autoregulation mechanism [1].

in vivo

thiostrepton suppressed tumor growth in a human breast cancer xenograft model. treatment with developed micelle-thiostrepton nanoparticles decreased xenograft tumor growth induced by the human mda-mb-231 breast and hepg2 liver cancer cell lines. these apoptosis activities in drug-treated tumors were correlated with in vivo suppression of oncogenic foxm1 [1].

References

[1] WILLIAM S BOWEN. Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain.[J]. The Journal of Biological Chemistry, 2005, 280 4: 2934-2943. DOI:10.1074/jbc.m407008200
[2] RUBEN L GONZALEZ Joseph D P Steven Chu. Thiostrepton inhibition of tRNA delivery to the ribosome.[J]. RNA, 2007: 2091-2097. DOI:10.1261/rna.499407
[3] JIMMY M-M KWOK. Thiostrepton selectively targets breast cancer cells through inhibition of forkhead box M1 expression.[J]. Molecular Cancer Therapeutics, 2008, 7 7: 2022-2032. DOI:10.1158/1535-7163.mct-08-0188

Thiostrepton Preparation Products And Raw materials

Raw materials

Preparation Products

Thiostrepton Suppliers

Global Suppliers ( 213)

Supplier	Tel	Email	Country	ProdList	Advantage
Zhejiang Huida Biotech Co., LTD	0571-89903022 18679456698	zilong@hizyme.com	China	8001	58
SHANG HAI WEI LING BIOTECHNOLOGY CO.,LTD	021-13917490980 13917490980	81939905@qq.com	China	483	58
Hangzhou Huiyi Biotechnology Co., LTD	0571-89918262 13357170655	chenlingwei@hizyme.com	China	103	58
Shanghai Degayuan Biotechnology Co., Ltd	18301711315 18301711315	851746237@qq.com	China	245	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2110	70
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9791	79

Supplier	Advantage
Zhejiang Huida Biotech Co., LTD	58
SHANG HAI WEI LING BIOTECHNOLOGY CO.,LTD	58
Hangzhou Huiyi Biotechnology Co., LTD	58
Shanghai Degayuan Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Beijing HwrkChemical Technology Co., Ltd	55
LGM Pharma	70
Chemsky（shanghai）International Co.,Ltd.	50
Sinopharm Chemical Reagent Co,Ltd.	79

View Latest Price from Thiostrepton manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-15	Thiostrepton 1393-48-2	$30.00-55.00		96.65%	10g	TargetMol Chemicals Inc.
2026-03-20	THIOSTREPTON 1393-48-2	$1.00	1kg	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2021-07-13	Thiostrepton 1393-48-2	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

Thiostrepton
1393-48-2
$30.00-55.00
96.65%
TargetMol Chemicals Inc.

THIOSTREPTON
1393-48-2
$1.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

Thiostrepton
1393-48-2
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Thiostrepton Spectrum

THIOSTREPTON(1393-48-2)MS

1393-48-2 (Thiostrepton) Related Search:

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1of4

Thiostrepton (200 mg) BryaMycin, Thiactin, AlaninaMide, X 146, A 8506, 6761-31 Thiostrepton, froM StreptoMyces sp. x146 Alaninamide, L-threonyl-(4S)-2-(1Z)-1-amino-1-propenyl-4,5-dihydro-4-thiazolecarbonyl-2-(1S,2S,3R)-1-amino-2,3-dihydroxy-2-methylbutyl-4-thiazolecarbonyl-2-(5R,6S)-6-2-(1S,2R)-1-amino-2-hydroxypropyl-4-thiazolyl-5-N-(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy THIOSTREPTION thiostrepton from streptomyces azureus Thiostrepton, 96%, from Streptomyces sp. Thiostrepton - CAS 1393-48-2 - Calbiochem AlaninaMide,N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-aMino-21-[(1S,2R)-1,2-dihydroxy-1-Methylpropyl]-14-ethylidene-3,4,4a,9,10,1 a-8506 antibiotic6761-31 antibiotica8506 antibioticx146 bryamycin thiactin Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahyd... THIOSTREPTON USP/EP/BP N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone hiostrepton Thiostrepton, USP Thiostreptin N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroala Thiostrepton, 10 mM in DMSO THIOSTREPTON USP (NON-STERILE BULK FORM) Thiostreptomycin (-)-Nuciferine Thiostrepton 1393-48-2 C72H85N19O18S5 Antibiotics T-Z Antibiotics Antibiotics A to Z BioChemical Inhibitors BETAPACE antibiotic Peptide Synthesis/Antibiotics Amino Acids & Derivatives Intermediates & Fine Chemicals Pharmaceuticals Antibacterial Antibiotics Antibiotics A to Antibiotics by Application Antibiotics T-ZAntibiotics Chemical Structure Class Gene Regulation and Expression Genetic Marker SelectionAntibiotics Interferes with Protein SynthesisSpectrum of Activity L - ZAntibiotics Mechanism of Action PeptidesCell Signaling and Neuroscience Organics RNA-Protein Translation InhibitorsMore...Close...