2-FORMYL-5-PICOLINE
- CAS No.
- 4985-92-6
- Chemical Name:
- 2-FORMYL-5-PICOLINE
- Synonyms
- 2-FORMYL-5-PICOLINE;5-Methylpicolinaldehyde;5-METHYL-2-PYRIDINALDEHYDE;5-Methylpyridine-2-carboxaldehyde;5-methyl-2-pyridinecarboxaldehyde;2-Pyridinecarboxaldehyde,5-Methyl-;5-Methylpyridine-2-carboxaldehydet;2-FORMYL-5-PICOLINE ISO 9001：2015 REACH
- CBNumber:
- CB6432768
- Molecular Formula:
- C7H7NO
- Molecular Weight:
- 121.14
- MDL Number:
- MFCD07367942
- MOL File:
- 4985-92-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 41.5 °C |
|---|---|
| Boiling point | 70-72 °C(Press: 0.7 Torr) |
| Density | 1.095±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | solid |
| pka | 4.01±0.10(Predicted) |
| Appearance | Off-white to light yellow <41.5°C Solid,>41.5°C Liquid |
| InChI | 1S/C7H7NO/c1-6-2-3-7(5-9)8-4-6/h2-5H,1H3 |
| InChIKey | SARODJOLCPBJHK-UHFFFAOYSA-N |
| SMILES | n1c(ccc(c1)C)C=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | WGK 3 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
2-FORMYL-5-PICOLINE price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SYX00325 | 5-Methylpyridine-2-carboxaldehyde | 4985-92-6 | 1g | $191 | 2026-04-30 | Buy |
| Apolloscientific | OR33604 | 5-Methylpyridine-2-carbaldehyde >98% | 4985-92-6 | 5g | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS50450 | 5-Methylpyridine-2-carboxaldehyde 98% | 4985-92-6 | 1g | $24 | 2026-06-04 | Buy |
| Activate Scientific | AS50450 | 5-Methylpyridine-2-carboxaldehyde 98% | 4985-92-6 | 5g | $49 | 2026-06-04 | Buy |
| Apolloscientific | OR33604 | 5-Methylpyridine-2-carbaldehyde >98% | 4985-92-6 | 25g | $86 | 2026-06-04 | Buy |
2-FORMYL-5-PICOLINE Chemical Properties, Uses, Production
Synthesis
3510-66-5
68-12-2
4985-92-6
General procedure for the synthesis of 5-methylpyridine-2-aldehyde from 2-bromo-5-methylpyridine and N,N-dimethylformamide: 50 g (290 mmol) of 2-bromo-5-methylpyridine was dissolved in 2500 mL of diethyl ether and cooled to -78 °C. Subsequently, 150 mL (380 mmol) of n-butyllithium (nBuLi) was slowly added dropwise and the reaction mixture was stirred at -78 °C for 2 hours. Next, 31.5 mL (407 mmol) of N,N-dimethylformamide (DMF) was slowly added and the reaction mixture was allowed to gradually warm up to room temperature. Upon completion of the reaction, water was added to the mixture for quenching. The organic and aqueous layers were separated and the aqueous layer was extracted three times with ethyl acetate. All organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent to give a brown oil. The residue was purified by fast column chromatography (eluent: heptane/ethyl acetate, gradient 0 to 25% ethyl acetate) to give 19 g (39% yield) of brown solid product. Mass spectrum (APCI): m/z 122 ([M+H]+). 1H NMR (CDCl3, 360 MHz) δ (ppm): 2.48 (s, 3H, CH3); 7.70 (dd, J = 7.9, 2.0 Hz, 1H, pyridine H4); 7.91 (d, J = 7.7 Hz, 1H, pyridine H3); 8.68 (s, 1H, pyridine H6); 10.10 (s, 1H, aldehyde group).
References
[1] Angewandte Chemie - International Edition, 2018, vol. 57, # 8, p. 2238 - 2243
[2] Angew. Chem., 2018, vol. 130, # 8, p. 2260 - 2265,6
[3] Patent: WO2009/60030, 2009, A1. Location in patent: Page/Page column 38-39
[4] Chemistry - A European Journal, 2008, vol. 14, # 17, p. 5313 - 5328
[5] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 24, p. 6763 - 6770
2-FORMYL-5-PICOLINE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Shanghai AmasPharm Co., Ltd. | 021-54540637 18621091017 | sales@amaspharm.com | China | 787 | 62 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
View Latest Price from 2-FORMYL-5-PICOLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-FORMYL-5-PICOLINE
4985-92-6
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-07-06 | 2-FORMYL-5-PICOLINE
4985-92-6
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- 2-FORMYL-5-PICOLINE
4985-92-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-FORMYL-5-PICOLINE
4985-92-6
- $1.00
- 98%
- Career Henan Chemical Co
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