5-IODOINDOLE
- CAS No.
- 16066-91-4
- Chemical Name:
- 5-IODOINDOLE
- Synonyms
- 5-IODO-1H-INDOLE;5-IODOINDOLE;5-Indoindole;5-Iodoindole 97%;1H-Indole, 5-iodo-;5-Iodo-1H-indole97%;5-Iodo-1H-indole 97%;5-Iodo-1H-indole, 95+%
- CBNumber:
- CB5205073
- Molecular Formula:
- C8H6IN
- Molecular Weight:
- 243.04
- MDL Number:
- MFCD00220065
- MOL File:
- 16066-91-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Iodoindole 97% | 563838 | 5g | $121 |
| 5-Iodoindole 97% | 563838 | 25g | $506 |
| 5-Iodo-1H-indole min. 95.0 % | I1239 | 1G | $30 |
| 5-Iodo-1H-indole min. 95.0 % | I1239 | 5G | $89 |
| 5-Iodoindole Asreported | 280268 | 5g | $425 |
| More product size | |||
| Melting point | 101-104 °C (lit.) |
|---|---|
| Boiling point | 341.7±15.0 °C(Predicted) |
| Density | 1.960±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 16.14±0.30(Predicted) |
| form | Solid or Crystalline Solid |
| color | White to pale brown |
| Sensitive | Light Sensitive |
| InChI | InChI=1S/C8H6IN/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5,10H |
| InChIKey | TVQLYTUWUQMGMP-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(I)C=C2)C=C1 |
| CAS DataBase Reference | 16066-91-4(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-IODOINDOLE price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 563838 | 5-Iodoindole 97% | 16066-91-4 | 5g | $121 | 2026-04-30 | Buy |
| Sigma-Aldrich | 563838 | 5-Iodoindole 97% | 16066-91-4 | 25g | $506 | 2023-06-20 | Buy |
| TCI Chemical | I1239 | 5-Iodo-1H-indole min. 95.0 % | 16066-91-4 | 1G | $30 | 2026-04-30 | Buy |
| TCI Chemical | I1239 | 5-Iodo-1H-indole min. 95.0 % | 16066-91-4 | 5G | $89 | 2026-04-30 | Buy |
| Usbiological | 280268 | 5-Iodoindole Asreported | 16066-91-4 | 5g | $425 | 2026-06-03 | Buy |
5-IODOINDOLE Chemical Properties,Uses,Production
Uses
5-Iodoindole is an important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field. It is used as the starting material in the synthesis of 5-(α-fluorovinyl)-N-tosylindole.
General Description
5-Iodoindole can be synthesized via nitration of m-toluidine.
Synthesis
10075-50-0
16066-91-4
The general procedure for the synthesis of 5-iodoindole from 5-bromoindole was as follows: CuI (9.6 mg, 0.0504 mmol, 5.0 mol%), 5-bromoindole (1.00 mmol if solid), and NaI (300 mg, 2.00 mmol) were added to a Schlenk tube, briefly evacuated and replaced three times with argon. Subsequently, N,N'-dimethyl-1,2-cyclohexanediamine (16 μL, 0.10 mmol, 10 mol%), 5-bromoindole (1.00 mmol if liquid) and dioxane (1.0 mL) were added under argon protection. The Schlenk tube was sealed with a polytetrafluoroethylene valve and the reaction mixture was stirred in an oil bath at 110°C for 22-23 hours. Upon completion of the reaction, the suspension was cooled to room temperature, diluted with 30% ammonia solution (5 mL), poured into water (20 mL) and extracted with dichloromethane (3 x 15 mL). The organic phases were combined, dried with anhydrous MgSO or NaSO and concentrated under reduced pressure, and the resulting crude product was purified by silica gel column chromatography to afford the target compound 5-iodoindole.
References
[1] Journal of the American Chemical Society, 2002, vol. 124, # 50, p. 14844 - 14845
[2] Patent: WO2004/13094, 2004, A2. Location in patent: Page 42-43
[3] Angewandte Chemie - International Edition, 2015, vol. 54, # 1, p. 263 - 266
[4] Angew. Chem., 2015, vol. 127, # 01, p. 265 - 268,4
[5] Catalysis Today, 2016, vol. 274, p. 129 - 132
5-IODOINDOLE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10817 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9631 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21135 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 | marketing1@neostarunited.com | China | 8827 | 58 |
View Lastest Price from 5-IODOINDOLE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-25 | 5-IODOINDOLE
16066-91-4
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 5-IODOINDOLE
16066-91-4
- $1.00
- 99%
- Career Henan Chemical Co
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