15D-PGJ2
- CAS No.
- 87893-55-8
- Chemical Name:
- 15D-PGJ2
- Synonyms
- 15D-PGJ2;15d-PGJ?;15-deoxy-Δ-12;15-deoxy-Δdelta12,14-Pgj 2;15-Deoxy-Delta12;14-Prostaglandin J2;15d-PGJ2;15-Deoxy-Δ12,14-PGJ2;12,14-prostaglandin J2
- CBNumber:
- CB5206904
- Molecular Formula:
- C20H28O3
- Molecular Weight:
- 316.43
- MDL Number:
- MFCD00065806
- MOL File:
- 87893-55-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 15-Deoxy-Δ12,14-prostaglandin J2 ≥95%(HPLC),1?mg/mLinmethylacetate | D8440 | 100μg | $52.2 |
| 15d-PGJ? | 538927 | 1mg | $217 |
| 15-deoxy-Δ12,14-Prostaglandin J2 ≥95%(mixtureofisomers) | 18570.1 | 1mg | $81 |
| 15-deoxy-Δ12,14-Prostaglandin J2 ≥95%(mixtureofisomers) | 18570.1 | 5mg | $357 |
| 15-deoxy-Δ12,14-Prostaglandin J2 ≥95% | 18570 | 100μg | $39 |
| Flash point | -9℃ |
|---|---|
| storage temp. | -20°C |
| solubility | Soluble in Methyl acetate (supplied pre-dissolved - 1mg/ml) |
| form | methyl acetate solution |
| color | Colorless to light yellow |
| InChI | 1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1 |
| InChIKey | VHRUMKCAEVRUBK-GODQJPCRSA-N |
| SMILES | CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O |
| FDA UNII | ALI977775J |
| UNSPSC Code | 12352211 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P305+P351+P338 | |||||||||
| target organs | Central nervous system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | F,Xi | |||||||||
| Risk Statements | 11-36/38-66-67-36 | |||||||||
| Safety Statements | 16-26-29-33-36/37/39 | |||||||||
| RIDADR | UN 1231 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
15D-PGJ2 price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D8440 | 15-Deoxy-Δ12,14-prostaglandin J2 ≥95%(HPLC),1?mg/mLinmethylacetate | 87893-55-8 | 100μg | $52.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 538927 | 15d-PGJ? | 87893-55-8 | 1mg | $217 | 2026-04-30 | Buy |
| Cayman Chemical | 18570.1 | 15-deoxy-Δ12,14-Prostaglandin J2 ≥95%(mixtureofisomers) | 87893-55-8 | 1mg | $81 | 2026-04-30 | Buy |
| Cayman Chemical | 18570.1 | 15-deoxy-Δ12,14-Prostaglandin J2 ≥95%(mixtureofisomers) | 87893-55-8 | 5mg | $357 | 2026-04-30 | Buy |
| Cayman Chemical | 18570 | 15-deoxy-Δ12,14-Prostaglandin J2 ≥95% | 87893-55-8 | 100μg | $39 | 2026-04-30 | Buy |
15D-PGJ2 Chemical Properties,Uses,Production
Uses
15-Deoxy-Δ12,14-prostaglandin J2 has been used:
- to study its effect on lipid accumulation, viability/mitochondrial activity, and amount of vasculature in vascularized adipose tissue model
- as a peroxisome proliferator-activated receptor (PPARγ) agonist to activate intestinal fatty acid binding protein (I-FABP)-PPARγ pathway
- as a supplement in culture medium for induced neural stem/progenitor cells (NSPCs) differentiation
Definition
ChEBI: 15-deoxy-Delta(12,14)-prostaglandin J2 is a prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions. It has a role as a metabolite, an electrophilic reagent and an insulin-sensitizing drug. It is functionally related to a prostaglandin J2. It is a conjugate acid of a 15-deoxy-Delta(12,14)-prostaglandin J2(1-).
General Description
A metabolite of PGD2 that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected 3T3 cells and for PPARγ response element (PPRE) in CV-1 cells. Competes with thiazolidinediones for PPARγ binding.
Biological Activity
Selective PPAR γ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC 50 = 7 μ M).
Biochem/physiol Actions
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) regulates inflammatory response in vivo. 15d-PGJ2 also elicits PPARγ-independent inhibition of nuclear factor (NF)-κB dependent transcription. It acts as an anti-angiogenic factor and triggers endothelial cell apoptosis.
15D-PGJ2 Preparation Products And Raw materials
Raw materials
Preparation Products
15D-PGJ2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1493 | 55 | |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 |
