Idazoxan hydrochloride
- CAS No.
- 79944-56-2
- Chemical Name:
- Idazoxan hydrochloride
- Synonyms
- RX 781094A;IdazoxanHCl;Idazoxan hydrochlori;Idazoxan hydrochloride;(+/-)-Idazoxan Monohydrochloride;Idazoxan hydrochloride, 10 mM in DMSO;2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE;Idazoxan hydrochloride, alpha2 Adrenoceptor antagonist and I2 ligand;RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride;Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride
- CBNumber:
- CB5236802
- Molecular Formula:
- C11H13ClN2O2
- Molecular Weight:
- 240.69
- MDL Number:
- MFCD00069293
- MOL File:
- 79944-56-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 207-208° |
|---|---|
| storage temp. | Store at RT |
| solubility | H2O: 300 mg/mL |
| form | Powder |
| color | White to off-white |
| Water Solubility | Soluble to 100 mM in water |
| Stability | Hygroscopic |
| InChI | InChI=1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H |
| InChIKey | MYUBYOVCLMEAOH-UHFFFAOYSA-N |
| SMILES | C1(COC2C=CC=CC=2O1)C1=NCCN1.Cl |
| FDA UNII | 15394QZS7A |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P310 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 7 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| Storage Class | 6.1C - Combustible, acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
Idazoxan hydrochloride price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I6138 | Idazoxan hydrochloride | 79944-56-2 | 50mg | $126 | 2026-04-30 | Buy |
| Sigma-Aldrich | I6138 | Idazoxan hydrochloride | 79944-56-2 | 100mg | $168 | 2026-04-30 | Buy |
| Sigma-Aldrich | 5.04746 | IdazoxanHydrochloride-CAS79944-56-2-Calbiochem | 79944-56-2 | 50mg | $146 | 2022-05-15 | Buy |
| Cayman Chemical | 41310 | Idazoxan (hydrochloride) ≥95% | 79944-56-2 | 5mg | $60 | 2026-04-30 | Buy |
| Cayman Chemical | 41310 | Idazoxan (hydrochloride) ≥95% | 79944-56-2 | 10mg | $102 | 2026-04-30 | Buy |
Idazoxan hydrochloride Chemical Properties, Uses, Production
Chemical Properties
mp 207-209°C
Uses
Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.
Uses
An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.
Uses
Antiparkinsonian;Alpha2 agonist
Biological Activity
α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).
Biochem/physiol Actions
α2-adrenoceptor antagonist; I2imidazoline receptor agonist; I1imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).
in vivo
Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25mg/kg. Idazoxan (0.3 and 2.5mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol[1].
| Animal Model: | Male CD-COBS rats injected with 1mg/kg haloperidol[1] |
| Dosage: | 0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0mg/kg |
| Administration: | Subcutaneous injection; for 1 hour |
| Result: | Potently reversed haloperidol-induced catalepsy with an ED50 of 0.25mg/kg. |
IC 50
α adrenergic receptor
Idazoxan hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Idazoxan hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| shanghai | 18918214718 | sales@fultrachem.com | China | 39 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
View Latest Price from Idazoxan hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Idazoxan hydrochloride
79944-56-2
|
$44.00-196.00 | 99.75% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-15 | Idazoxan hydrochloride
79944-56-2
|
$44.00-196.00 | 99.75% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-28 | Idazoxan hydrochloride
79944-56-2
|
$68.00-304.00 | 99.84% | 10g | TargetMol Chemicals Inc. |
-
- Idazoxan hydrochloride
79944-56-2
- $44.00-196.00
- 99.75%
- TargetMol Chemicals Inc.
-
- Idazoxan hydrochloride
79944-56-2
- $44.00-196.00
- 99.75%
- TargetMol Chemicals Inc.
-
- Idazoxan hydrochloride
79944-56-2
- $68.00-304.00
- 99.84%
- TargetMol Chemicals Inc.
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