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IDAZOXAN HYDROCHLORIDE

IDAZOXAN HYDROCHLORIDE Structure
IDAZOXAN HYDROCHLORIDE structure
CAS No.
79944-56-2
Chemical Name:
IDAZOXAN HYDROCHLORIDE
Synonyms
RX 781094A;IdazoxanHCl;Idazoxan hydrochlori;IDAZOXAN HYDROCHLORIDE;(+/-)-Idazoxan Monohydrochloride;Idazoxan hydrochloride, 10 mM in DMSO;2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE;Idazoxan hydrochloride, alpha2 Adrenoceptor antagonist and I2 ligand;RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride;Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride
CBNumber:
CB5236802
Molecular Formula:
C11H13ClN2O2
Molecular Weight:
240.69
MDL Number:
MFCD00069293
MOL File:
79944-56-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-13 13:05:00
Product description Number Pack Size Price
Idazoxan hydrochloride I6138 50mg $126
Idazoxan hydrochloride I6138 100mg $168
IdazoxanHydrochloride-CAS79944-56-2-Calbiochem 5.04746 50mg $146
Idazoxan (hydrochloride) ≥95% 41310 5mg $60
Idazoxan (hydrochloride) ≥95% 41310 10mg $102
Request For Quotation

IDAZOXAN HYDROCHLORIDE Properties

Melting point 207-208°
storage temp. Store at RT
solubility H2O: 300 mg/mL
form Powder
color White to off-white
Water Solubility Soluble to 100 mM in water
Stability Hygroscopic
InChI InChI=1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H
InChIKey MYUBYOVCLMEAOH-UHFFFAOYSA-N
SMILES C1(COC2C=CC=CC=2O1)C1=NCCN1.Cl
FDA UNII 15394QZS7A
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  Xn
Risk Statements  22
Safety Statements  7
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
Storage Class 6.1C - Combustible, acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral

IDAZOXAN HYDROCHLORIDE price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I6138 Idazoxan hydrochloride 79944-56-2 50mg $126 2026-04-30 Buy
Sigma-Aldrich I6138 Idazoxan hydrochloride 79944-56-2 100mg $168 2026-04-30 Buy
Sigma-Aldrich 5.04746 IdazoxanHydrochloride-CAS79944-56-2-Calbiochem 79944-56-2 50mg $146 2022-05-15 Buy
Cayman Chemical 41310 Idazoxan (hydrochloride) ≥95% 79944-56-2 5mg $60 2026-04-30 Buy
Cayman Chemical 41310 Idazoxan (hydrochloride) ≥95% 79944-56-2 10mg $102 2026-04-30 Buy
Product number Packaging Price Buy
I6138 50mg $126 Buy
I6138 100mg $168 Buy
5.04746 50mg $146 Buy
41310 5mg $60 Buy
41310 10mg $102 Buy

IDAZOXAN HYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

mp 207-209°C

Uses

Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.

Uses

An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.

Uses

Antiparkinsonian;Alpha2 agonist

Biological Activity

α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).

Biochem/physiol Actions

α2-adrenoceptor antagonist; I2imidazoline receptor agonist; I1imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).

in vivo

Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25mg/kg. Idazoxan (0.3 and 2.5mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol[1].

Animal Model:Male CD-COBS rats injected with 1mg/kg haloperidol[1]
Dosage:0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0mg/kg
Administration:Subcutaneous injection; for 1 hour
Result:Potently reversed haloperidol-induced catalepsy with an ED50 of 0.25mg/kg.

IC 50

α adrenergic receptor

IDAZOXAN HYDROCHLORIDE synthesis

1008-92-0
107-15-3
79944-56-2
Synthesis of IDAZOXAN HYDROCHLORIDE from 2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBONITRILE and Ethylenediamine

IDAZOXAN HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

1,4-Benzodioxin-2-carboximidic acid, 2,3-dihydro-, ethyl ester, hydrochloride (1:1) 2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBONITRILE Ethylenediamine Catechol

Preparation Products

IDAZOXAN HYDROCHLORIDE Suppliers

Global( 89)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39040 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501; +undefined18621343501 product@acmec-e.com China 33324 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19957 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
shanghai 17354719950 sales@fultrachem.com China 37 58
J & K SCIENTIFIC LTD. 18210857532; 18210857532 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15838 69
Supplier Advantage
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		58
shanghai 58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69

View Lastest Price from IDAZOXAN HYDROCHLORIDE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Idazoxan hydrochloride pictures 2026-05-13 Idazoxan hydrochloride
79944-56-2
 US $135.00-44.00 / mg 99.42% 10g TargetMol Chemicals Inc.
Idazoxan hydrochloride pictures 2026-05-13 Idazoxan hydrochloride
79944-56-2
 US $135.00-44.00 / mg 99.42% 10g TargetMol Chemicals Inc.
Idazoxan hydrochloride pictures 2025-04-28 Idazoxan hydrochloride
79944-56-2
 US $304.00-186.00 / mg 99.84% 10g TargetMol Chemicals Inc.

IDAZOXAN HYDROCHLORIDE Spectrum

IDAZOXAN HYDROCHLORIDE(79944-56-2)1HNMR

79944-56-2(IDAZOXAN HYDROCHLORIDE)Related Search:

2-PHENOXYPROPYLAMINE HYDROCHLORIDE 2-METHOXYACETAMIDINE HYDROCHLORIDE 2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYLAMINE 2-Isopropoxyphenol propionamidine hydrochloride
2-(2-Methoxyphenoxy)ethylamine 2-PHENOXYACETAMIDINE HYDROCHLORIDE 1,4-Benzodioxan 2-(2-METHOXYPHENOXY)-N-METHYLETHYLAMINE 3-AMINO-1-PHENOXY-2-PROPANOL HYDROCHLORIDE, 98
Idazoxan AKOS BBS-00007965 CHEMBRDG-BB 9070636 1,4-BENZODIOXAN-2-METHYLAMINE, N-METHYL- 2-HYDROXY-PROPIONAMIDINE
CHEMBRDG-BB 5482082 1-AMINO-3-PHENOXY-PROPAN-2-OL 2-HYDROXY-ACETAMIDINE HCL

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(+/-)-Idazoxan Monohydrochloride 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride RX 781094A 2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride IDAZOXAN HYDROCHLORIDE 2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE IdazoxanHCl RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride Idazoxan hydrochlori RX781094,inhibit,Adrenergic Receptor,RX-781094,Idazoxan,Inhibitor,Beta Receptor,Idazoxan hydrochloride,Imidazoline Receptor Idazoxan hydrochloride, alpha2 Adrenoceptor antagonist and I2 ligand Idazoxan hydrochloride, 10 mM in DMSO 79944-56-2 79944-65-2 Adrenoceptor Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals