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IDAZOXAN HYDROCHLORIDE

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Products Intro: Product Name:Idazoxan hydrochloride
CAS:79944-56-2
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CAS:79944-56-2
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Products Intro: Product Name:Idazoxan HCl
CAS:79944-56-2
Purity:98% Package:50mg Remarks:V12840
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Products Intro: Product Name:Idazoxan hydrochloride
CAS:79944-56-2
Purity:99.84% Package:25mg;|50mg;|5mg;43USD
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Products Intro: Product Name:Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride
CAS:79944-56-2
Purity:97% Package:10g, 100mg, 1g, 250mg

IDAZOXAN HYDROCHLORIDE manufacturers
IDAZOXAN HYDROCHLORIDE Basic information
Product Name:IDAZOXAN HYDROCHLORIDE
Synonyms:(+/-)-Idazoxan Monohydrochloride;2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride;RX 781094A;2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride;IDAZOXAN HYDROCHLORIDE;2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE;IdazoxanHCl;RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride
CAS:79944-56-2
MF:C11H13ClN2O2
MW:240.69
EINECS:
Product Categories:Adrenoceptor;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:79944-56-2.mol
IDAZOXAN HYDROCHLORIDE Structure
IDAZOXAN HYDROCHLORIDE Chemical Properties
Melting point 207-208°
storage temp. Store at RT
solubility H2O: 300 mg/mL
form Powder
color White to off-white
Water Solubility Soluble to 100 mM in water
Stability:Hygroscopic
InChIInChI=1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H
InChIKeyMYUBYOVCLMEAOH-UHFFFAOYSA-N
SMILESC1(COC2C=CC=CC=2O1)C1=NCCN1.Cl
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 7
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
Storage Class6.1C - Combustible, acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard ClassificationsAcute Tox. 3 Oral
MSDS Information
ProviderLanguage
SigmaAldrich English
IDAZOXAN HYDROCHLORIDE Usage And Synthesis
Chemical Propertiesmp 207-209°C
UsesIdazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.
UsesAn α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.
UsesAntiparkinsonian;Alpha2 agonist
Biological Activityα 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).
Biochem/physiol Actionsα2-adrenoceptor antagonist; I2imidazoline receptor agonist; I1imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).
in vivo

Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25mg/kg. Idazoxan (0.3 and 2.5mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol[1].

Animal Model:Male CD-COBS rats injected with 1mg/kg haloperidol[1]
Dosage:0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0mg/kg
Administration:Subcutaneous injection; for 1 hour
Result:Potently reversed haloperidol-induced catalepsy with an ED50 of 0.25mg/kg.
IC 50α adrenergic receptor
Tag:IDAZOXAN HYDROCHLORIDE(79944-56-2) Related Product Information
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