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Idazoxan hydrochloride manufacturers
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| | Idazoxan hydrochloride Basic information |
| Product Name: | Idazoxan hydrochloride | | Synonyms: | (+/-)-Idazoxan Monohydrochloride;2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-iMidazole Hydrochloride;RX 781094A;2-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-iMidazole hydrochloride;2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE HYDROCHLORIDE;IdazoxanHCl;RX 781094, (±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride;Idazoxan hydrochloride,2-(1,4-Benzodioxan-2-yl)-2-imidazolinehydrochloride | | CAS: | 79944-56-2 | | MF: | C11H13ClN2O2 | | MW: | 240.69 | | EINECS: | | | Product Categories: | Adrenoceptor;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 79944-56-2.mol |  |
| | Idazoxan hydrochloride Chemical Properties |
| Melting point | 207-208° | | storage temp. | Store at RT | | solubility | H2O: 300 mg/mL | | form | Powder | | color | White to off-white | | Water Solubility | Soluble to 100 mM in water | | Stability: | Hygroscopic | | InChI | InChI=1S/C11H12N2O2.ClH/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11;/h1-4,10H,5-7H2,(H,12,13);1H | | InChIKey | MYUBYOVCLMEAOH-UHFFFAOYSA-N | | SMILES | C1(COC2C=CC=CC=2O1)C1=NCCN1.Cl |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 7 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | Storage Class | 6.1C - Combustible, acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral |
| | Idazoxan hydrochloride Usage And Synthesis |
| Chemical Properties | mp 207-209°C | | Uses | Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems. | | Uses | An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian. | | Uses | Antiparkinsonian;Alpha2 agonist | | Biological Activity | α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively). | | Biochem/physiol Actions | α2-adrenoceptor antagonist; I2imidazoline receptor agonist; I1imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS). | | in vivo | Idazoxan (0.16-5 mg/kg; subcutaneous injection; for 1 hour; male CD-COBS rats) treatment potently reverses haloperidol-induced catalepsy with an ED50 of 0.25mg/kg. Idazoxan (0.3 and 2.5mg/kg) has no effect on extracellular DA and do not modify the rise of extracellular DA induced by haloperidol[1]. | Animal Model: | Male CD-COBS rats injected with 1mg/kg haloperidol[1] | | Dosage: | 0.16 mg/kg, 0.31 mg/kg, 0.63 mg/kg, 1.25 mg/kg, 2.5 mg/kg, and 5.0mg/kg
| | Administration: | Subcutaneous injection; for 1 hour | | Result: | Potently reversed haloperidol-induced catalepsy with an ED50 of 0.25mg/kg.
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| | IC 50 | α adrenergic receptor |
| | Idazoxan hydrochloride Preparation Products And Raw materials |
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