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ChemicalBook >> CAS DataBase List >>1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE

1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE

1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE Structure
1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE structure
CAS No.
364-11-4
Chemical Name:
1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE
Synonyms
2-Bromo-5-iodobenzotrifluoride;1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE;Benzene, 1-bromo-4-iodo-2-(trifluoromethyl)-;1-Bromo-4-iodo-2-(trifluoromethyl)benzene, 2-Bromo-5-iodo-alpha,alpha,alpha-trifluorotoluene
CBNumber:
CB52467048
Molecular Formula:
C7H3BrF3I
Molecular Weight:
350.9
MDL Number:
MFCD11855999
MOL File:
364-11-4.mol
MSDS File:
SDS
Last updated:2026-05-28 01:30:57
Product description Number Pack Size Price
2-Bromo-5-iodobenzotrifluoride ≥95% PC51000 1g $21
2-Bromo-5-iodobenzotrifluoride ≥95% PC51000 5g $28
2-Bromo-5-iodobenzotrifluoride ≥95% PC51000 25g $47
1-Bromo-4-iodo-2-trifluoromethylbenzene 98% AS204262 5g $30
1-Bromo-4-iodo-2-trifluoromethylbenzene 98% AS204262 25g $89
More product size
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1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE Properties

Melting point 78-80℃ (water )
Boiling point 245.1±35.0℃ (760 Torr)
Density 2.176±0.06 g/cm3 (20 ºC 760 Torr)
Flash point 102.1±25.9℃
storage temp. Keep in dark place,Sealed in dry,2-8°C
form crystals
color Faint orange/pale salmon (hint of pink)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501
HS Code  2903998090

1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC51000 2-Bromo-5-iodobenzotrifluoride ≥95% 364-11-4 1g $21 2026-06-04 Buy
Apolloscientific PC51000 2-Bromo-5-iodobenzotrifluoride ≥95% 364-11-4 5g $28 2026-06-04 Buy
Apolloscientific PC51000 2-Bromo-5-iodobenzotrifluoride ≥95% 364-11-4 25g $47 2026-06-04 Buy
Activate Scientific AS204262 1-Bromo-4-iodo-2-trifluoromethylbenzene 98% 364-11-4 5g $30 2026-06-04 Buy
Activate Scientific AS204262 1-Bromo-4-iodo-2-trifluoromethylbenzene 98% 364-11-4 25g $89 2026-06-04 Buy
Product number Packaging Price Buy
PC51000 1g $21 Buy
PC51000 5g $28 Buy
PC51000 25g $47 Buy
AS204262 5g $30 Buy
AS204262 25g $89 Buy

1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE Chemical Properties,Uses,Production

Synthesis

4-Bromo-3-(trifluoromethyl)aniline

393-36-2

1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE

364-11-4

The general procedure for the synthesis of 2-bromo-5-iodobenzotrifluoride from 5-amino-2-bromobenzotrifluoride was as follows: first, 4-bromo-3-(trifluoromethyl)aniline (500 mg, 2.08 mmol) was dissolved in a mixture of preheated concentrated sulfuric acid (37% w/w, 0.51 mL, 4.6 eq.) and water (2.3 mL, concentration = 3.4 M). Under vigorous stirring, the reaction mixture was cooled to -10 °C (using an ice-salt bath), at which point the aniline bisulfate precipitated as a slurry. Subsequently, an aqueous solution of sodium nitrite (NaNO2, 158 mg, 1.1 eq.) was added slowly and dropwise (1.06 mL, concentration = 2.15 M). After continued stirring at -8 °C for 40 min, an aqueous solution of potassium iodide (KI, 495 mg, 1.43 equiv) (0.4 mL, concentration = 8 M) and copper powder (4 mg) were added. The reaction mixture was gradually warmed to room temperature (ice bath removed) and stirred for 30 minutes. Next, the reaction was heated to reflux (102 °C) and kept for 1 hour. Upon completion of the reaction, it was cooled to room temperature, diluted with water and the aqueous layer was extracted with dichloromethane (DCM, 3 x 20 mL). The combined organic phases were washed sequentially with saturated sodium thiosulfate (Na2S2O3, 20 mL) and brine (20 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: hexane) to afford the target compound 2-bromo-5-iodobenzotrifluoride in 93% yield (679 mg) as an orange solid. The structure of the product was confirmed by 1H NMR and 13C NMR.

References

[1] Patent: WO2013/167730, 2013, A1. Location in patent: Page/Page column 90
[2] Angewandte Chemie - International Edition, 2009, vol. 48, # 43, p. 8070 - 8073
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 21, p. 9096 - 9104
[4] Patent: WO2016/63300, 2016, A1. Location in patent: Page/Page column 8
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 1, p. 233 - 249

1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE Preparation Products And Raw materials

Raw materials

5-BROMO-2-IODOBENZOTRIFLUORIDE Trifluoroacetic acid 4-Bromo-3-(trifluoromethyl)aniline 1-Bromo-4-iodobenzene Sodium nitrite
Copper Potassium iodide

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Preparation Products

4-BROMO-3-TRIFLUOROMETHYL-BENZALDEHYDE

1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE Suppliers

Global( 106)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-173 9270 1263 1057@dideu.com China 3961 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Fuxin Pharmaceutical 		+86-021-021-50872116 contact@fuxinpharm.com China 9976 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +86-189 4982 3763 sales@tnjchem.com China 34526 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14301 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +8619957148339 market18@leapchem.com China 24569 58
Aladdin Scientific 		tp@aladdinsci.com United States 54746 58
Allfluoro Pharmaceutical Company Limited 		+86-400-0216110 +86-15958047586 sales@allfluoro.com China 11380 58
Shenzhen Nexcon Pharmatechs Ltd. 		+86-0755-89396905 +86-18025329037 admin@nexconn.com China 6198 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Capot Chemical Co.,Ltd. 		60
career henan chemical co 		58
Fuxin Pharmaceutical 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Win-Win chemical CO., Limited 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Aladdin Scientific 		58
Allfluoro Pharmaceutical Company Limited 		58
Shenzhen Nexcon Pharmatechs Ltd. 		58

View Lastest Price from 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE pictures 2024-06-11 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE
364-11-4
 $1.00 1Kg 98% 20T Shaanxi Dideu Medichem Co. Ltd
1-Bromo-4-iodo-2-trifluoromethylbenzene pictures 2022-01-15 1-Bromo-4-iodo-2-trifluoromethylbenzene
364-11-4
 1KG 98.5% 100 tons Honest Joy Holdings Limited
1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE pictures 2019-09-03 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE
364-11-4
 $7.00 1KG 98% Career Henan Chemical Co

1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE Spectrum

1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE(364-11-4)1HNMR

364-11-4(1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE)Related Search:

2-Bromobenzotrifluoride Benzene, 2-bromo-5-iodo-1,3-bis(trifluoromethyl)- 2-BroMo-1-iodo-3-(trifluoroMethyl)benzene Benzene, 1-bromo-2-(difluoromethyl)-4-iodo- 2-bromo-4-iodo-1-(trifluoromethyl)benzene
2-Bromo-4-fluoro-5-iodobenzotrifluoride

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1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE 1-Bromo-4-iodo-2-(trifluoromethyl)benzene, 2-Bromo-5-iodo-alpha,alpha,alpha-trifluorotoluene 2-Bromo-5-iodobenzotrifluoride Benzene, 1-bromo-4-iodo-2-(trifluoromethyl)- 364-11-4