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4-Bromo-3-(trifluoromethyl)aniline

4-Bromo-3-(trifluoromethyl)aniline structure

CAS No.: 393-36-2

Chemical Name:: 4-Bromo-3-(trifluoromethyl)aniline

Synonyms: 5-AMINO-2-BROMOBENZOTRIFLUORIDE;4-BROMO-3-TRIFLUOROMETHYL-PHENYLAMINE;BUTTPARK 37\11-68;5-AMINO-2-BROMOBE;5-Amino-2-bromobenzotrifluo;Amino-2-bromobenzotrifluoride;3-Trifluoromethyl-4-bromoanili;2-BROMO-5-AMINOBENZOTRIFLUORIDE;3-trifluoromethyl-4-bromoaniline;4-BROMO-3-(TRIFLUOROMETHYL)ANILINE

CBNumber:: CB9242401

Molecular Formula:: C7H5BrF3N

Molecular Weight:: 240.02

MDL Number:: MFCD00007827

MOL File:: 393-36-2.mol

MSDS File:: SDS

Last updated:2026-05-28 04:51:19

Product description	Number	Pack Size	Price
4-Bromo-3-(trifluoromethyl)aniline 98%	297712	5g	$50
4-Bromo-3-(trifluoromethyl)aniline 98%	297712	25g	$147
5-Amino-2-bromobenzotrifluoride >98.0%(GC)(T)	A1847	5g	$30
5-Amino-2-bromobenzotrifluoride >98.0%(GC)(T)	A1847	25g	$85
4-Bromo-3-(trifluoromethyl)aniline	TRC-B810695-500MG	500mg	$78
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4-Bromo-3-(trifluoromethyl)aniline Properties

Melting point	47-49 °C(lit.)
Boiling point	81-84 °C0.5 mm Hg(lit.)
Density	1.6925 (rough estimate)
refractive index	1.5320 (estimate)
Flash point	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	soluble in Methanol
form	Solid:crystalline
pka	2.67±0.10(Predicted)
color	White to Orange to Green
PH	6.86 at 25℃ and 10g/L
BRN	641589
InChI	1S/C7H5BrF3N/c8-6-2-1-4(12)3-5(6)7(9,10)11/h1-3H,12H2
InChIKey	YGNISOAUPSJDJE-UHFFFAOYSA-N
SMILES	Nc1ccc(Br)c(c1)C(F)(F)F
LogP	2.7 at 30℃
CAS DataBase Reference	393-36-2(CAS DataBase Reference)
NIST Chemistry Reference	5-Amino-2-bromobenzotrifluoride(393-36-2)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38

Safety Statements

26-36

RIDADR

2811

WGK Germany

Hazard Note

Irritant

HazardClass

6.1

HS Code

29214300

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Aquatic Chronic 2
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1B
STOT RE 2 Oral

REACH Registrations

Active

NFPA 704

	1
3		0

4-Bromo-3-(trifluoromethyl)aniline price More Price(70)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	297712	4-Bromo-3-(trifluoromethyl)aniline 98%	393-36-2	5g	$50	2023-06-20	Buy
Sigma-Aldrich	297712	4-Bromo-3-(trifluoromethyl)aniline 98%	393-36-2	25g	$147	2023-06-20	Buy
TCI Chemical	A1847	5-Amino-2-bromobenzotrifluoride >98.0%(GC)(T)	393-36-2	5g	$30	2026-04-30	Buy
TCI Chemical	A1847	5-Amino-2-bromobenzotrifluoride >98.0%(GC)(T)	393-36-2	25g	$85	2026-04-30	Buy
TRC	TRC-B810695-500MG	4-Bromo-3-(trifluoromethyl)aniline	393-36-2	500mg	$78	2026-06-03	Buy

Product number	Packaging	Price	Buy
297712	5g	$50	Buy
297712	25g	$147	Buy
A1847	5g	$30	Buy
A1847	25g	$85	Buy
TRC-B810695-500MG	500mg	$78	Buy

4-Bromo-3-(trifluoromethyl)aniline Chemical Properties,Uses,Production

Chemical Properties

White to off-white crystalline

Uses

4-Bromo-3-(trifluoromethyl)aniline has been used in the preparation of:

2,5-dibromo-(trifluoromethyl)benzene and 2-bromo-5-iodo-(trifluoromethyl)benzene
AUY954, an aminocarboxylate analog of FTY720, a low nanomolar, monoselective agonist of the sphingosine-1-phosphate receptor

Synthesis

367-67-9

393-36-2

General procedure for the synthesis of 5-amino-2-bromobenzotrifluoride from 2-bromo-5-nitrobenzotrifluoride: 300 mL of methanol, 284 g of 2-bromo-5-nitrobenzotrifluoride, 20 g of Raney Ni Catalyst, and 1.0 g of piperazine were added to a 1 L high pressure hydrogenation reactor. The air in the reactor was replaced with hydrogen 3-4 times, followed by the hydrogenation reaction at a hydrogen pressure of 0.8-1.0 MPa and 80-90 °C until no more hydrogen was consumed. Upon completion of the reaction, the reaction mixture was cooled and filtered to remove the Raney Ni catalyst. Methanol and water were removed by distillation under reduced pressure, and the final product was obtained by simple distillation as a pale yellow liquid product, 5-amino-2-bromobenzotrifluoride, 250 g, with a GC purity of 95% and a yield of 98.8%.The Raney Ni catalyst and the solvent, methanol, can be recovered for reuse.

References

[1] Patent: CN106905104, 2017, A. Location in patent: Paragraph 0020; 0022
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 3932

4-Bromo-3-(trifluoromethyl)aniline synthesis

Synthesis of 4-Bromo-3-(trifluoromethyl)aniline from 3-Aminobenzotrifluoride

4-Bromo-3-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

2-Bromo-5-nitrobenzotrifluoride Methanol Piperazine Hydrogen 4-BROMO-3-(TRIFLUOROMETHYL)ACETANILIDE

2-Bromobenzotrifluoride 3-(TRIFLUOROMETHYL)ACETANILIDE 3-Aminobenzotrifluoride 2-Aminobenzotrifluoride

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Preparation Products

2-Bromo-5-(trifluoromethyl)aniline 2-bromo-3-(trifluoromethyl)aniline 4-BROMO-3-TRIFLUOROMETHYL-BENZALDEHYDE 3-Trifluoromethyl-4-bromobenzonitrile 4-Bromo-2-iodo-5-(trifluoromethyl)aniline

Benzoic acid, 4-(methoxymethoxy)-, ethyl ester

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4-Bromo-3-(trifluoromethyl)aniline Suppliers

Global( 401)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Blocksynth Pharmaceutical Technology Co.,Ltd	0086-19817745290; 19817745290	bd@blocksynth.com	China	5971	58
Hebei Chuanghai Biotechnology Co., Ltd	+86-15350571055	Sibel@chuanghaibio.com	China	8737	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1002	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14032	58
Hi-Tech Chemistry Corp	0519-86626038	yuhh@hitechem.com	CHINA	809	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21531	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32998	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2949	58

Supplier	Advantage
Blocksynth Pharmaceutical Technology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hangzhou ICH Biofarm Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Hi-Tech Chemistry Corp	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Finer Chemical Co., Ltd	58

View Lastest Price from 4-Bromo-3-(trifluoromethyl)aniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-08	4-Bromo-3-(trifluoromethyl)aniline 393-36-2			99.0%min	20000kg	Hangzhou ICH Biofarm Co., Ltd
2026-06-30	4-Bromo-3-(trifluoromethyl)aniline 393-36-2		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-03-20	4-Bromo-3-(trifluoromethyl)aniline 393-36-2	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

4-Bromo-3-(trifluoromethyl)aniline
393-36-2
99.0%min
Hangzhou ICH Biofarm Co., Ltd

4-Bromo-3-(trifluoromethyl)aniline
393-36-2
98.0%
Shaanxi Dideu New Materials Co. Ltd

4-Bromo-3-(trifluoromethyl)aniline
393-36-2
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Bromo-3-(trifluoromethyl)aniline Spectrum

4-Bromo-3-(trifluoromethyl)aniline(393-36-2)¹HNMR 4-Bromo-3-(trifluoromethyl)aniline(393-36-2)IR 4-Bromo-3-(trifluoromethyl)aniline(393-36-2)Raman 4-Bromo-3-(trifluoromethyl)aniline(393-36-2)FT-IR

393-36-2(4-Bromo-3-(trifluoromethyl)aniline)Related Search:

4-Bromo-3-(trifluoromethyl)aniline 2-Bromo-5-nitrobenzotrifluoride 4-BROMO-3-(TRIFLUOROMETHYL)ACETANILIDE 2-bromo-3-(trifluoromethyl)aniline 2-BROMO-4-(TRIFLUOROMETHYL)ANILINE

2-Bromobenzotrifluoride Bicalutamide 4-Bromoaniline Toluene 2-Bromo-5-(trifluoromethyl)aniline

2-Amino-5-bromobenzotrifluoride 5-Bromo-2-(trifluoromethyl)aniline 4-Amino-2-(trifluoromethyl)benzonitrile 3-Amino-5-bromobenzotrifluoride 4-BROMO-5-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE

N-(4-BROMO-5-(TRIFLUOROMETHYL)-2-NITROPHENYL)ACETAMIDE 4-BROMO-2-FLUORO-5-(TRIFLUOROMETHYL)ANILINE N-(2-AMINO-4-BROMO-5-(TRIFLUOROMETHYL)PHENYL)ACETAMIDE

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4-Bromo-alpha,alpha,alpha-trifluoro-m-toluidine Benzenamine, 4-bromo-3-(trifluoromethyl)- 5-amino-2-bromo-trifluoromethylbenzene / 4-bromo-3-trifluoromethyl-aniline 4-Bromo-3-(trifluoromethyl)aniline, 4-Bromo-alpha,alpha,alpha-trifluoro-m-toluidine 2-BROMO-5-AMINOBENZOTRIFLUORIDE 4-BROMO-3-(TRIFLUOROMETHYL)ANILINE 4-AMINO-1-BROMO-2-(TRIFLUOROMETHYL)BENZENE BUTTPARK 37\11-68 3-trifluoromethyl-4-bromoaniline 3-Trifluoromethyl-4-bromoanili 5-amino-2-bromobenzotrifluoride (intermediate of bicalutamide) 5-Amino-2-bromobenzotrifluoride 97% 5-Amino-2-bromobenzotrifluoride97% 4-bromo-3-(Trilfuoromethyl)aniline 1-Bromo-2-(trifluoromethyl)-4-aminobenzene 4-Bromo-3-(trifluoromethyl)benzenamine 5-Amino-2-bromobenzotrifluo 4-BROMO-3-(TRIFLUOROMETHYL)ANILIME 4-BROMO-3-(TRIFLUOROMETHYL)ANILINE / 5-AMINO-2-BROMOBENZOTRIFLUORIDE 4-BROMO-3-(TRIFLUOROMETHYL)ANILINE 98% 4-Amino-1-bromo-2-(trifluoromethyl)benzene 4-Bromo-3-(trifluoromethyl)aniline 4-Bromo-3-(trifluoromethyl)aniline,98% 5-AMINO-2-BROMOBE 4-Bromo-3-(trifluoromethyl)aniline 98%min 5-Amino-2-bromobenzotrifluoride > Amino-2-bromobenzotrifluoride 4-Bromo-3-(trifluoromethyl)aniline ISO 9001：2015 REACH 4-bromo-?,?,?-trifluoro-m-toluidine 4-Bromo-3-(trifluoromethyl)aniline,96% 4-bromo-α,α,α-trifluoro-m-toluidine 4-BROMO-3-TRIFLUOROMETHYL-PHENYLAMINE 5-AMINO-2-BROMOBENZOTRIFLUORIDE 393-36-2 393-63-6 93-36-2 396-36-2 BrC6H3CF3NH2 Organic Building Blocks Nitrogen Compounds C7 Building Blocks Amines Miscellaneous Benzotrifluoride Series C7 Nitrogen Compounds Aniline series Aniline Amines blocks Bromides Building Blocks Chemical Synthesis Nitrogen Compounds Organic Building Blocks Trifluoromethylbenzene serise amine| alkyl bromide bc0001