1,14-diamino-3,6,9,12-tetraoxatetradecane
- CAS No.
- 68960-97-4
- Chemical Name:
- 1,14-diamino-3,6,9,12-tetraoxatetradecane
- Synonyms
- NH2-PEG4-NH2;3,6,9,12-Tetraoxatetradecane-1,14-diaMine;Amino-PEG4-Amine;mino-PEG4-Amine;Amine-PEG4-amine;Amino-dPEG4-Amino;Amino-PEG4-Amine,NH2-PEG4-NH2;Aminopentapolyethylene glycol amine;1,14-diamino-3,6,9,12-tetraoxatetradecane;Triethylene Glycol Bis(2-aminoethyl) Ether
- CBNumber:
- CB52469749
- Molecular Formula:
- C10H24N2O4
- Molecular Weight:
- 236.31
- MDL Number:
- MFCD01365938
- MOL File:
- 68960-97-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 139°C/0.2mmHg(lit.) |
|---|---|
| Density | 1.043±0.06 g/cm3(Predicted) |
| refractive index | 1.4650 to 1.4690 |
| storage temp. | -20°C |
| solubility | Soluble in Water, DMSO, DCM, DMF |
| pka | 9.04±0.10(Predicted) |
| form | clear liquid |
| color | Colorless to Light yellow |
| InChI | InChI=1S/C10H24N2O4/c11-1-3-13-5-7-15-9-10-16-8-6-14-4-2-12/h1-12H2 |
| InChIKey | IFZOPNLVYZYSMQ-UHFFFAOYSA-N |
| SMILES | C(N)COCCOCCOCCOCCN |
| UNSPSC Code | 51171641 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
| RIDADR | UN 2735 8/PG III | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2942000090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 |
|||||||||
| NFPA 704 |
|
1,14-diamino-3,6,9,12-tetraoxatetradecane price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | JKA12010 | NH2-PEG4-NH2 | 68960-97-4 | 500MG | $345 | 2026-04-30 | Buy |
| TCI Chemical | T3198 | 1,14-Diamino-3,6,9,12-tetraoxatetradecane >97.0%(GC) | 68960-97-4 | 100mg | $112 | 2026-04-30 | Buy |
| Usbiological | 516917 | Amine-PEG4-Amine (3,6,9,12-Tetraoxatetradecane-1,14-diamine) ≥95% | 68960-97-4 | 5g | $708 | 2026-06-03 | Buy |
| ChemPep | 281705-5G | H2N-PEG4-CH2CH2NH2 | 68960-97-4 | 5g | $768 | 2026-06-04 | Buy |
| ChemPep | 281705-1G | H2N-PEG4-CH2CH2NH2 | 68960-97-4 | 1g | $309 | 2026-06-04 | Buy |
1,14-diamino-3,6,9,12-tetraoxatetradecane Chemical Properties, Uses, Production
Description
Amino-PEG4-Amine is a very useful crosslinker containing two amino groups. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
Uses
Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization
Synthesis
109789-39-1
68960-97-4
The general procedure for the synthesis of 3,6,9,12-tetraoxatetradecane-1,14-diamine from the compound (CAS:109789-39-1) is as follows: 9.1 mmol of methanesulfonyloxy-diethyleneglycol-methanesulfonate (MsO-PEG2-OMs) was dissolved in an appropriate amount of dichloromethane. To this solution, excess ammonia and 2 mmol of tetrabutylammonium bromide were added as a phase transfer catalyst, followed by stirring the reaction at 45 °C for 12 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator and then purified by distillation under reduced pressure to afford the target product 3,6,9,12-tetraoxatetradecane-1,14-diamine (NH2-PEG4-NH2) in a yield of 7.64 mmol and 84%.
IC 50
PEGs
References
[1] Patent: CN107840817, 2018, A. Location in patent: Paragraph 0050; 0052
[2] Inorganic Chemistry, 2015, vol. 54, # 14, p. 6807 - 6820
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2016, vol. 54, # 20, p. 3294 - 3302
1,14-diamino-3,6,9,12-tetraoxatetradecane Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yaopu(Shanghai) Pharmaceutical Technology Co., Ltd | 50929289 18616309303 | sales@ypptech.com.cn | China | 383 | 58 |
| Affinity Linkers Ltd. | 15841022315 15841022315 | sales@affinitytech.cn | China | 7039 | 58 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| ChemPep, Inc. | +1 (888) 615-9178 / (561) 791-8787 | service@chempep.com | United States | 2138 | 57 |
| Chengdu Pukang Biotechnology Co., Ltd | 18217049878 | cassie.gao@pu-kang.com | China | 480 | 58 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2297 | 55 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
View Latest Price from 1,14-diamino-3,6,9,12-tetraoxatetradecane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | Amino-PEG4-C2-amine
68960-97-4
|
$2.00-6.00 | 1kg | 99% | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-07-24 | 3,6,9,12-tetraoxatetradecane-1,14-diamine
68960-97-4
|
1g | 98% | 68960-97-4 | XIAMEN SINOPEG BIOTECH CO., LTD. | ||
 |
2026-07-15 | Amino-PEG4-C2-amine
68960-97-4
|
10g | TargetMol Chemicals Inc. |
-
- Amino-PEG4-C2-amine
68960-97-4
- $2.00-6.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 3,6,9,12-tetraoxatetradecane-1,14-diamine
68960-97-4
- 98%
- XIAMEN SINOPEG BIOTECH CO., LTD.
-
- Amino-PEG4-C2-amine
68960-97-4
- $0.00
- TargetMol Chemicals Inc.
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