Amino-PEG2-acid
- CAS No.
- 791028-27-8
- Chemical Name:
- Amino-PEG2-acid
- Synonyms
- NH2-PEG2-COOH;H2N-PEG2-CH2CH2COOH;Amino-PEG2-COOH;Amino-PEG2-C2-acid;Amino-PEG2-acid;AMINE-PEG2-COOH;H2N-PEG2-CH2CH2COOH.HCl;H2N-(CH2CH2O)2-CH2CH2COOH;Amino-PEG2-propionic acid;α-amine-ω-propionic acid diethylene glycol
- CBNumber:
- CB62501433
- Molecular Formula:
- C7H15NO4
- Molecular Weight:
- 177.2
- MDL Number:
- MFCD20926377
- MOL File:
- 791028-27-8.mol
- MSDS File:
- SDS
| Boiling point | 331.5±27.0 °C(Predicted) |
|---|---|
| Density | 1.142±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in water |
| pka | 4.27±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| Appearance | white to off-yellow powder |
| InChI | InChI=1S/C7H15NO4/c8-2-4-12-6-5-11-3-1-7(9)10/h1-6,8H2,(H,9,10) |
| InChIKey | DEZXLFKSYRODPB-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CCOCCOCCN |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
| HS Code | 2918999090 |
Amino-PEG2-acid price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 516836 | Amino-PEG2-acid (alpha;-amine-omega;-propionic acid diethylene glycol) ≥95% | 791028-27-8 | 5g | $758 | 2026-06-03 | Buy |
| Biosynth | FP73006 | 3-(2-(2-Aminoethoxy)ethoxy)-propanoic acid | 791028-27-8 | 250mg | $290 | 2026-06-04 | Buy |
| Biosynth | FP73006 | 3-(2-(2-Aminoethoxy)ethoxy)-propanoic acid | 791028-27-8 | 500mg | $455 | 2026-06-04 | Buy |
| Biosynth | FP73006 | 3-(2-(2-Aminoethoxy)ethoxy)-propanoic acid | 791028-27-8 | 1000mg | $720 | 2026-06-04 | Buy |
| Biosynth | FP73006 | 3-(2-(2-Aminoethoxy)ethoxy)-propanoic acid | 791028-27-8 | 2000mg | $1180 | 2026-06-04 | Buy |
Amino-PEG2-acid Chemical Properties, Uses, Production
Description
Amino-PEG2-acid is a PEG reagent containing an amino group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Uses
Amino-PEG2-C2-acid is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG2-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biological Activity
Amino-PEG2-C2-acid is a cleavable 3-unit PEG ADClinker for the synthesis of antibody-drug conjugated Ck (ADC). It is also a PEG-based PROTAClinker that can be used for PROTAC synthesis.
in vivo
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
IC 50
Cleavable Linker; PEGs
References
[1] Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof. WO2016197946A1.
Amino-PEG2-acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Junnahe Biopharmaceutical Co., Ltd | 025-58367986 17351780683 | amy.xiang@ally-chem.com | China | 354 | 60 |
| Shanghai Huici Pharmaceutical Technology Co., LTD | 133-31922809 19372841038 | lixing@pharmahuici.com | China | 853 | 58 |
| Sichuan Tongsheng Amino acids Co.,Ltd. | 0838-2274206 17340404235 | sales@biots.cn | China | 300 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Beijing Isomersyn Technology CO;LTD | 010-82954736 13391601435 | sales@isomersyn.com | China | 3294 | 57 |
| ChemPep, Inc. | +1 (888) 615-9178 / (561) 791-8787 | service@chempep.com | United States | 2138 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Chengdu Pukang Biotechnology Co., Ltd | 18217049878 | cassie.gao@pu-kang.com | China | 480 | 58 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
View Latest Price from Amino-PEG2-acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-03 | Amino-PEG2-acid
791028-27-8
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-04-20 | Amino-PEG2-C2-acid
791028-27-8
|
10g | TargetMol Chemicals Inc. | ||||
 |
2026-01-29 | NH2-PEG2-CH2CH2COOH
791028-27-8
|
1g | 98% | 300kg | LAURENT |
-
- Amino-PEG2-acid
791028-27-8
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- Amino-PEG2-C2-acid
791028-27-8
- $0.00
- TargetMol Chemicals Inc.
-
- NH2-PEG2-CH2CH2COOH
791028-27-8
- 98%
- LAURENT
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