Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate
- CAS No.
- 105486-72-4
- Chemical Name:
- Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate
- Synonyms
- Ethyl 5-bromo-1-methyl-1h-pyrazole-4-formate;ethyl 5-bromo-1-methyl-pyrazole-4-carboxylate;Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate;5-Bromo-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester;1H-PYRAZOLE-4-CARBOXYLIC ACID, 5-BROMO-1-METHYL-, ETHYL ESTER;5-bromo-1-methyl-1H-Pyrazole-4-carboxylic acid ethyl ester (9CI ACI);1H-Pyrazole-4-carboxylic acid, 5-bromo-1-methyl-, ethyl ester (9CI, ACI)
- CBNumber:
- CB52471504
- Molecular Formula:
- C7H9BrN2O2
- Molecular Weight:
- 233.06
- MDL Number:
- MFCD13189831
- MOL File:
- 105486-72-4.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate >98% | E60583 | 250mg | $44 |
| Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate >98% | E60583 | 1g | $50 |
| Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate >98% | E60583 | 5g | $220 |
| Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate >98% | E60583 | 10g | $360 |
| Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate ≥95% | AA007WA9 | 100mg | $10 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P501-P270-P264-P301+P312+P330 |
Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | E60583 | Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate >98% | 105486-72-4 | 250mg | $44 | 2026-05-06 | Buy |
| Synthonix | E60583 | Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate >98% | 105486-72-4 | 1g | $50 | 2026-05-06 | Buy |
| Synthonix | E60583 | Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate >98% | 105486-72-4 | 5g | $220 | 2026-05-06 | Buy |
| Synthonix | E60583 | Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate >98% | 105486-72-4 | 10g | $360 | 2026-05-06 | Buy |
| aablocks | AA007WA9 | Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate ≥95% | 105486-72-4 | 100mg | $10 | 2026-05-28 | Buy |
Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate Chemical Properties,Uses,Production
Synthesis
31037-02-2
105486-72-4
General procedure for the synthesis of ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate from ethyl 5-amino-1-methylpyrazole-4-carboxylate: Intermediate 1: (5-bromo-1-methyl-1H-pyrazol-4-yl)-(octahydro-quinolin-1-yl)methanone; Step 1: To a mixed solution containing tert-butyl nitrite (29.5 mL, 221.5 mmol), copper bromide (39.7 g, 177.5 mmol), and acetonitrile, ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate (25 g, 148 mmol) was slowly added over a 30-minute period. The reaction mixture was stirred at room temperature for 2 hours, followed by warming up to 65 °C and continued stirring for 1 hour. After completion of the reaction, the mixture was poured into 6N HCl (400 mL) and extracted with dichloromethane. The organic phase was concentrated in vacuum and the resulting crude product was purified by fast chromatography using a 0-20% ethyl acetate/hexane gradient elution to give ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate (28 g, 81% yield).
References
[1] Patent: US2006/223852, 2006, A1. Location in patent: Page/Page column 10
[2] Patent: WO2013/189904, 2013, A1. Location in patent: Page/Page column 49
[3] Patent: US2012/214791, 2012, A1. Location in patent: Page/Page column 23
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1001 - 1018
Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate Preparation Products And Raw materials
Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Hefei Hangang Pharmaceutical Technology Co., Ltd. | +8618062405514 | ada@ipurechemical.com | China | 10224 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; 19817745290 | bd@blocksynth.com | China | 5971 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-18168183658 | sales1@artkmedchem.com | China | 39007 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53799 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7882 | 64 |
