1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]PYRROLIDINE
![1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]PYRROLIDINE Structure](CAS/GIF/852227-90-8.gif)
- CAS No.
- 852227-90-8
- Chemical Name:
- 1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]PYRROLIDINE
- Synonyms
- 4-Pyrrolidinophenylboronic acid, pinacol ester;4-(PYRROLIDIN-1-YL)BENZENEBORONIC ACID, PINACOL ESTER;4-(Pyrrolidin-1-yl)benzeneboronicacid,pinacolester95%;4-(1-Pyrrolidinyl)benzeneboronic acid pinacol ester, 97%;1-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl);4-(Pyrrolidin-1-yl)benzeneboronic acid, pinacol ester 97%;1-[4-(4,4,5,5-TetraMethyl-dioxaborolan-2-yl)phenyl]pyrrolidine;1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]PYRROLIDINE;1-[4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl) pheny]pyrrolidine;Pyrrolidine, 1-[4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)phenyl]-
- CBNumber:
- CB5248238
- Molecular Formula:
- C16H24BNO2
- Molecular Weight:
- 273.18
- MDL Number:
- MFCD08060504
- MOL File:
- 852227-90-8.mol
| Melting point | 109 °C |
|---|---|
| Boiling point | 396.0±25.0 °C(Predicted) |
| Density | 1.05 |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | 5.14±0.40(Predicted) |
| Appearance | Off-white to gray Solid |
| Water Solubility | Slightly soluble in water. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]PYRROLIDINE price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | T889553 | 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine | 852227-90-8 | 1g | $285 | 2021-12-16 | Buy |
| TRC | T889553 | 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine | 852227-90-8 | 100mg | $45 | 2021-12-16 | Buy |
| AK Scientific | X2493 | 4-Pyrrolidinophenylboronicacidpinacolester | 852227-90-8 | 5g | $427 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | ING0003355 | 1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]PYRROLIDINE 95.00% | 852227-90-8 | 250MG | $440 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | ING0003355 | 1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]PYRROLIDINE 95.00% | 852227-90-8 | 1G | $541 | 2021-12-16 | Buy |
1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]PYRROLIDINE Chemical Properties,Uses,Production
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
Synthesis
22090-26-2
73183-34-3
![1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]PYRROLIDINE](/CAS/GIF/852227-90-8.gif)
852227-90-8
General procedure for the synthesis of 1-(4-(4-bromophenyl)pyrrolidine and bis(pinacolato)diboron (1.21 g, 4.78 mmol) from 1-(4-bromophenyl)pyrrolidine and pinacolato)diboron (1.21 g, 4.78 mmol) in a flask protected by argon gas containing 1-(4-bromophenyl)pyrrolidine (722 mg, 3.19 mmol), bis(pinacolato)diboron (1.21 g, 4.78 mmol), potassium acetate (939 mg, 9.56 mmol) and PdCl2 (dppf) (79 mg, 0.097 mmol). 4.78 mmol), potassium acetate (939 mg, 9.56 mmol), and PdCl2(dppf) (79 mg, 0.097 mmol) were added to a flask pre-purged with argon (30 mL) of 1,4-dioxane. The reaction mixture was refluxed under argon atmosphere for 14 hours. Upon completion of the reaction, the reaction mixture was extracted with hexane and the organic phases were combined, dried over anhydrous sodium sulfate and filtered. Purification by silica gel column chromatography (eluent: hexane/ethyl acetate = 17:3) gave a black needle-like target product (575 mg, 2.10 mmol, 66% yield). Thin layer chromatography (TLC, silica gel plate, unfolding agent: chloroform) showed Rf = 0.60.1H NMR (CDCl3) data: δ = 1.32 (12H, s), 1.92-2.1 (4H, m), 3.23-3.4 (4H, m), 6.53 (2H, dd, J = 6.5, 1.8 Hz), 7.67 (2H, dd, J = 6.5, 1.8 Hz). 1.8 Hz).APCI-MS (CHCl3) analysis: m/z calculated value C16H25BNO2 ([MH]+) is 274.1973; measured value is 274.2256.
References
[1] Bulletin of the Chemical Society of Japan, 2018, vol. 91, # 10, p. 1506 - 1514
1-[4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PHENYL]PYRROLIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29733 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | alfa10@alfachem.cn | China | 12977 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 |
