(R)-2-Aminomethyl-4-boc-morpholine
- CAS No.
- 1174913-80-4
- Chemical Name:
- (R)-2-Aminomethyl-4-boc-morpholine
- Synonyms
- tert-butyl (2R)-2-(aminomethyl)morpholine-4-carboxylate;(R)-4-Boc-2-aminomethylmorpholine;(R)-2-Aminomethyl-4-boc-morpholine;(R)-N-BOC-2-AMINOMETHYLMORPHOLINE OXALATE;tert-Butyl-2-(aminomethyl)morpholin-4-carboxylat;(R)-tert-butyl 2-aMinoMethylMorpholine-4-carboxylate;tert-Butyl-(2R)-2-(aminomethyl)morpholin-4-carboxylat;(R)-2-(Aminomethyl)morpholine-4-carboxylic acid tert-butyl ester;4-Morpholinecarboxylic acid, 2-(aMinoMethyl)-, 1,1-diMethylethyl ester, (2R)-
- CBNumber:
- CB52490866
- Molecular Formula:
- C10H20N2O3
- Molecular Weight:
- 216.28
- MDL Number:
- MFCD13189480
- MOL File:
- 1174913-80-4.mol
- MSDS File:
- SDS
| Boiling point | 311℃ |
|---|---|
| Density | 1.078 |
| Flash point | 142℃ |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 9.37±0.29(Predicted) |
| Appearance | Colorless to off-white Solid-Liquid Mixture |
| optical activity | 24.83°(C=0.01g/ml MEOH) |
| InChI | InChI=1S/C10H20N2O3/c1-10(2,3)15-9(13)12-4-5-14-8(6-11)7-12/h8H,4-7,11H2,1-3H3/t8-/m1/s1 |
| InChIKey | MTMBHUYOIZWQAJ-MRVPVSSYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCO[C@H](CN)C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| HS Code | 2934999090 |
(R)-2-Aminomethyl-4-boc-morpholine price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 51121 | (R)-2-AMINOMETHYL-4-BOC-MORPHOLINE 95% | 1174913-80-4 | 1G | $77 | 2026-04-30 | Buy |
| AstaTech | 51121 | (R)-2-AMINOMETHYL-4-BOC-MORPHOLINE 95% | 1174913-80-4 | 5G | $233 | 2026-04-30 | Buy |
| Matrix Scientific | 124408 | (R)-2-Aminomethyl-4-Boc-morpholine | 1174913-80-4 | 1.00g | $1073 | 2026-05-18 | Buy |
| Synthonix | A14962 | (R)-2-Aminomethyl-4-Boc-morpholine 97.0% | 1174913-80-4 | 1g | $60 | 2026-05-06 | Buy |
| Synthonix | A14962 | (R)-2-Aminomethyl-4-Boc-morpholine 97.0% | 1174913-80-4 | 250mg | $210 | 2026-05-06 | Buy |
(R)-2-Aminomethyl-4-boc-morpholine Chemical Properties, Uses, Production
Synthesis
1132683-15-8
1174913-80-4
Step 3. tert-Butyl (S)-2-(azidomethyl)morpholine-4-carboxylate (1.0 eq.) was dissolved in ethanol (0.1 M) under argon protection. To this solution was added Pd/C catalyst (0.20 eq.), followed by three evacuations of the reaction system and replacement with hydrogen gas. The reaction mixture was stirred at room temperature and under atmospheric pressure hydrogen atmosphere (using a hydrogen balloon) for 24 hours. Upon completion of the reaction, the hydrogen was removed by evacuation and the reaction system was replaced with argon. The reaction mixture was filtered through a diatomaceous earth pad and concentrated under reduced pressure to afford tert-butyl (R)-2-(aminomethyl)morpholine-4-carboxylate as a white solid in 91% yield.LCMS analysis showed (m/z) [M+H]+ = 217.1 and retention time (Rt) = 0.43 min.
References
[1] Patent: US2014/275003, 2014, A1. Location in patent: Paragraph 0188
[2] Journal of Medicinal Chemistry, 2009, vol. 52, # 15, p. 4810 - 4819
[3] Patent: US2015/259350, 2015, A1. Location in patent: Paragraph 0065; 0073
[4] Patent: KR101745741, 2017, B1. Location in patent: Paragraph 0119; 0132
(R)-2-Aminomethyl-4-boc-morpholine Preparation Products And Raw materials
(R)-2-Aminomethyl-4-boc-morpholine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| skychemical Co.Ltd | 021-20960837,QQ1332204249 | sales@skychemical.com | China | 3338 | 55 |
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2712 | 61 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Chembon Pharmaceutical Co., Ltd. | 028-84252981 18583719936 | sales@chembon.com.cn | China | 854 | 64 |
| Shanghai Sheepchem Co., Ltd. | +86 (21) 6715-7650 | sheepchem@163.com | China | 993 | 60 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| EnliPharma Technology Co., Ltd | 0551-66399836 18955197623 | sales@enlipharma.com | China | 1875 | 55 |
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1998 | 55 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Hygeia (Chengdu) pharmaceutical technique Co., Ltd | 028-84502008 13568869383 | sales@hygeiapharm.com | China | 291 | 55 |
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