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(2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid

(2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid structure

CAS No.: 147266-92-0

Chemical Name:: (2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid

Synonyms: (2R,4S)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;BOC-D-HYP-OH;N-Boc-trans-D-Hyp-OH;BOC-TRANS-4-HYDROXY-D-PROLINE;Boc-trans-D-Hyp-OH;Boc-D-trans-Hyp-OH;trans-Boc-D-Hpy-OH;BOC-D-PRO(4-HYDROXY)-OH;Prusogliptin Impurity 16;Teneligliptin Impurity 27

CBNumber:: CB7345548

Molecular Formula:: C10H17NO5

Molecular Weight:: 231.25

MDL Number:: MFCD01861341

MOL File:: 147266-92-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:54:55

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(2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid Properties

Melting point	123°C
Boiling point	390.9±42.0 °C(Predicted)
Density	1.312±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	3.80±0.40(Predicted)
form	solid
color	White
optical activity	[α]/D +70°, c = 0.617 g/mL in methanol
Major Application	peptide synthesis
InChI	1S/C10H17NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7/m0/s1
InChIKey	BENKAPCDIOILGV-PKPIPKONSA-N
SMILES	CC(C)(C)OC(=O)N1C[C@@H](O)CC1C(O)=O
FDA UNII	7K1V4SDL4L
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319

Precautionary statements

P305+P351+P338

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

HazardClass

IRRITANT

HS Code

2933998090

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2

NFPA 704

	1
0		0

(2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid price More Price(67)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	762067	N-Boc-trans-4-hydroxy-D-proline 97%	147266-92-0	1g	$166	2026-04-30	Buy
Sigma-Aldrich	762067	N-Boc-trans-4-hydroxy-D-proline 97%	147266-92-0	500mg	$110	2023-06-20	Buy
Usbiological	265617	Boc-trans-4-hydroxy-D-proline Asreported	147266-92-0	250mg	$340	2026-06-03	Buy
Usbiological	265617	Boc-trans-4-hydroxy-D-proline Asreported	147266-92-0	500mg	$468	2026-06-03	Buy
Usbiological	265617	Boc-trans-4-hydroxy-D-proline Asreported	147266-92-0	1g	$686	2026-06-03	Buy

Product number	Packaging	Price	Buy
762067	1g	$166	Buy
762067	500mg	$110	Buy
265617	250mg	$340	Buy
265617	500mg	$468	Buy
265617	1g	$686	Buy

(2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

Boc protected Proline derivative.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

51-35-4

(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID

147266-92-0

General procedure for the synthesis of N-BOC-trans-4-hydroxy-D-proline from di-tert-butyl dicarbonate and L-hydroxyproline: Step A: Preparation of (4β)-1-Boc-4-hydroxy-L-proline 1. dissolve L-hydroxyproline (5.08 g, 38.77 mmol) in a solvent mixture of 1N NaOH solution (40 mL) and 1,4-dioxane (40 mL). 2. Di-tert-butyl dicarbonate (9.3 g, 42.6 mmol) was added drop-wise to the above solution at 0 °C. 3. The reaction mixture was stirred at room temperature for 8 hours. 4. 4. After completion of the reaction, the mixture was concentrated under vacuum to remove the solvent. 5. The concentrated mixture was acidified with 1N HCl and then extracted with EtOAc. 6. The organic extract was washed with brine, dried over MgSO4 and filtered. 7. Finally, the filtrate was concentrated under vacuum to give N-BOC-trans-4-hydroxy-D-proline (8.84 g, 99% yield). MS [M + H] = 232 (M + 1).

IC 50

Non-cleavable Linker

References

[1] Patent: WO2010/56022, 2010, A2. Location in patent: Page/Page column 21

(2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid synthesis

Synthesis of (2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid from Di-tert-butyl dicarbonate and L-Hydroxyproline

(2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

(4R)-4-Hydroxy-1-Boc-D-proline ethyl ester 1,4-Dioxane Sodium hydroxide trans-4-Hydroxy-D-proline Di-tert-butyl dicarbonate

L-Hydroxyproline

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Preparation Products

(1R,4R)-tert-Butyl 3-oxo-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate N-Boc-Trans-4-Hydroxy-D-proline methyl ester

(2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid Suppliers

Global( 179)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7882	64
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Jia Xing Isenchem Co.,Ltd	66
Tetranov Biopharm	64
Accela ChemBio Co.,Ltd.	64
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
China DongFan Chemical Co.,LTD	66

View Lastest Price from (2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Manufacturer
2021-07-13	(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBO 147266-92-0	$10.00-15.00	1KG	99%+ HPLC	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBO 147266-92-0	$10.00-15.00	1KG	99%+ HPLC	Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID 147266-92-0	$100.00	1KG	99%	Career Henan Chemical Co

(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBO
147266-92-0
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBO
147266-92-0
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
147266-92-0
$100.00
99%
Career Henan Chemical Co

(2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid Spectrum

(2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID(147266-92-0)¹HNMR

147266-92-0((2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid)Related Search:

(2R,4R)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID Boc-Hyp-OH (2R,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid (2R,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI)

tert-Butyl 3-oxoazetidine-1-carboxylate Methyl 8-azabicyclo[3.2.1... (R)-2-Aminomethyl-4-boc-morpholine (S)-tert-Butyl 4,4-difluoro-2-(hydroxymethyl)-pyrrolidine-1-carboxylate trans-4-Hydroxy-D-proline

N-Boc-trans-4-Hydroxy-L-proline methyl ester trans-4-Hydroxy-D-proline hydrochloride (2S,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID N-Boc-Trans-4-Hydroxy-D-proline methyl ester Boc-Hyp-OH

1of3

(2R,4S)-N-Boc-trans-4-hydroxy-D-proline (2R,4S)-N-Boc-cis-4-hydroxy-D-proline Boc-D-trans-Hyp-OH N-Boc-trans-4-hydroxy-D-proline 95+% (2R,4S)-N-Boc-4-hydroxy-D-proline (2R,4S)-4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 1-tert-Butoxycarbonyl-(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) ester, (2R-trans)- Boc-trans-D-Hyp-OH 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) ester, (2R,4S)- trans-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid (2R,4S)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) ester Boc-(2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid Boc-trans-4-hydroxy-D-proline≥ 95% (NMR) BOC-D-PRO(4-HYDROXY)-OH BOC-D-HYP-OH N-T-BOC-TRANS-4-HYDROXY-D-PROLINE N-ALPHA-T-BUTOXYCARBONYL-D-HYDROXYPROLINE N-Boc-trans-4-Hydroxy-D-proline N-BOC-CIS-7-HYDROXY-D-PROLINE (Tert-Butoxy)Carbonyl D-trans-Hyp-OH N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline (2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylicaci (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID USP/EP/BP (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARBO N-tert-Boc-trans-4-Hydroxy-D-proline (2R,4s)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid (2R,4S)-N-ALPHA-T-BUTOXYCARBONYL-4-HYDROXYPYRROLIDINE-2-CARB... trans-Boc-D-Hpy-OH (2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-car 1-(1,1-Dimethylethyl) (2R,4S)-4-hydroxy-1,2-pyrrolidinedicarboxylate Prusogliptin Impurity 16 N-tert-butoxycarbonyl-D-trans-4- hydroxyproline Tenteligliptin impurity 2 (2R,4S)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2- carboxylic acid (2R,4S)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid/N-tert-butoxycarbonyl-D-trans-4-hydroxyproline N-Boc-trans-4-hydroxy-D-proline N-Boc-trans-4-hydroxy-D-proline, 97% Teneligliptin Impurity 27 1-(tert-Butyl) (2R,4S)-4-hydroxy-1,2-pyrrolidinedicarboxylate (2R,4S)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid BOC-TRANS-4-HYDROXY-D-PROLINE N-Boc-trans-D-Hyp-OH (2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid 147266-92-0 C10H17NO8 C10H17F2NO5