Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>1-Boc-3-azetidinone

1-Boc-3-azetidinone

1-Boc-3-azetidinone Structure
1-Boc-3-azetidinone structure
CAS No.
398489-26-4
Chemical Name:
1-Boc-3-azetidinone
Synonyms
TERT-BUTYL 3-OXOAZETIDINE-1-CARBOXYLATE;1-BOC-3-AZETIDINONE;N-Boc-3-azetidinone;3-OXO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;N-Boc-Azetidin-3-one;tert-Butyl 3-Ox;Baricitinib-011;1-Boc azitidone;CAS:398489-26-4;N-boc-3-azetidine
CBNumber:
CB5282384
Molecular Formula:
C8H13NO3
Molecular Weight:
171.19
MDL Number:
MFCD01861741
MOL File:
398489-26-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:15:08
Request For Quotation

1-Boc-3-azetidinone Properties

Melting point 47-51 °C
Boiling point 251.3±33.0 °C(Predicted)
Density 1.174±0.06 g/cm3(Predicted)
Flash point 102 °C
storage temp. Inert atmosphere,2-8°C
solubility Chloroform (Sparingly), Dichloromethane (Slightly)
pka -1.99±0.20(Predicted)
form Crystalline Powder
color White to off-white
Sensitive Moisture Sensitive/Stench
InChI InChI=1S/C8H13NO3/c1-8(2,3)12-7(11)9-4-6(10)5-9/h4-5H2,1-3H3
InChIKey VMKIXWAFFVLJCK-UHFFFAOYSA-N
SMILES N1(C(OC(C)(C)C)=O)CC(=O)C1
CAS DataBase Reference 398489-26-4(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  22-37/38-41
Safety Statements  26-39
RIDADR  UN 3335
WGK Germany  3
HazardClass  IRRITANT
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
REACH Registrations Inactive
NFPA 704
1
2 0

1-Boc-3-azetidinone price More Price(106)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 696315 1-Boc-3-azetidinone 97% 398489-26-4 1g $107 2026-04-30 Buy
TCI Chemical B3988 1-(tert-Butoxycarbonyl)-3-azetidinone >98.0%(GC) 398489-26-4 1g $42 2026-04-30 Buy
TCI Chemical B3988 1-(tert-Butoxycarbonyl)-3-azetidinone >98.0%(GC) 398489-26-4 5g $123 2026-04-30 Buy
Usbiological 262871 1-Boc-3-azetidinone 398489-26-4 10g $319 2026-06-03 Buy
Usbiological 262871 1-Boc-3-azetidinone 398489-26-4 25g $446 2026-06-03 Buy
Product number Packaging Price Buy
696315 1g $107 Buy
B3988 1g $42 Buy
B3988 5g $123 Buy
262871 10g $319 Buy
262871 25g $446 Buy

1-Boc-3-azetidinone Chemical Properties, Uses, Production

Chemical Properties

White to light brown solid

Uses

1-Boc-3-azetidinone can be used for the preparation of antibacterial aminoglycoside analogs.

Uses

tert-Butyl 3-oxoazetidine-1-carboxylate(1-Boc-3-azetidinone) is a currently common organic intermediate. It is a key intermediate for preparing various medicaments. It can be used for preparing Janus kinase 3(JAKS), which is a useful target for immunosuppression and transplant rejection, and can be used for treating inflammatory disorders, autoimmune disorders, cancer and other diseases; also useful in the preparation of a second class of HCV protease inhibitors useful in the treatment of HCV genotype 1 infection; can also be used for preparing novel aminoglycoside compounds with antibacterial activity; bicyclic himbacine (himbacine) derivatives can be prepared which are useful as antagonists of the protease activated receptor-1 (PAR-1) and are predicted to be cannabis (CB2) receptor inhibitors, useful for the treatment of secondary prevention of Acute Coronary Syndrome (ACS), myocardial infarction or thrombotic stroke or peripheral arterial disease; bicyclic azacyclobenzylamine derivatives, such as pyridopyrimidines, can be prepared that modulate the activity of phospho-inositol 3-kinase (P13K) and are useful in the treatment of diseases associated with P13K, including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

General Description

tert-Butyl 3-oxoazetidine-1-carboxylate is moisture sensitive and incompatible with oxidizing agents. This chemical can cause skin irritation and severe eye irritation.

Synthesis

The traditional preparation method of tert-Butyl 3-oxoazetidine-1-carboxylate is mainly to oxidize the hydroxyl on an aza ring into ketone. For example: 3-azetidinium alkoxide, di-tert-butyl dicarbonate and sodium bicarbonate in dioxane: stirring the mixture of water for 15 hours to obtain 3-hydroxyazetidine-1-carboxylic acid-1, 1-dimethylethyl ester; dissolving 3-hydroxyazetidine-1-carboxylic acid-1, 1-dimethyl ethyl ester in ethanedioyl chloride and dichloromethane, adding DMSO and triethylamine, stirring at room temperature for 15 hours to obtain tert-Butyl 3-oxoazetidine-1-carboxylate.

synthesis route of tert-Butyl 3-oxoazetidine-1-carboxylate

References

[1] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 5, p. 550 - 555
[2] Journal of the American Chemical Society, 2013, vol. 135, # 42, p. 15742 - 15745
[3] Patent: US2012/35122, 2012, A1. Location in patent: Paragraph 0622; 0623
[4] Patent: WO2013/116236, 2013, A1. Location in patent: Page/Page column 28
[5] Patent: WO2013/169622, 2013, A1. Location in patent: Page/Page column 53; 54

1-Boc-3-azetidinone synthesis

141699-55-0
398489-26-4
Synthesis of 1-Boc-3-azetidinone from 1-N-Boc-3-hydroxyazetidine

1-Boc-3-azetidinone Preparation Products And Raw materials

Raw materials

1-N-Boc-3-hydroxyazetidine Triethylamine Dimethyl sulfoxide

Preparation Products

1-Boc-3-iodoazetidine 3-Hydroxy-3-methyl-azetidine-1-carboxylic acid tert-butyl ester 1-(Tert-butoxycarbonyl)-3-(methanesulfonyloxy)azetidine 1-Azetidinecarboxylicacid,3-ethyl-3-hydroxy-,1,1-dimethylethylester(9CI) tert-Butyl 3-hydroxy-3-(2-methoxyphenyl)azetidine-1-carboxylate
2-tert-Butyl 8-methyl 5-thia-2-azaspiro[3.4]octane-2,8-dicarboxylate 5,5-dioxide 3-(trifluoroMethyl)azetidin-3-olHCL tert-butyl 3-(2-tosylhydrazono)azetidine-1-carboxylate tert-butyl 3-(hydroxyimino)azetidine-1-carboxylate 3-(5-broMo-2,3-dihydro-indol-1-yl)-azetidine-1-carboxylic acid tert-butyl ester
1-Boc-3-[(2-hydroxyethyl)amino]-azetidine 1-(tert-Butoxycarbonyl)-3-(dimethylamino)azetidine 3-Hydroxy-3-phenylazetidine-1-carboxylic acid tert-butyl ester

1of3

1-Boc-3-azetidinone Suppliers

Global Suppliers ( 509)
Supplier Tel Email Country ProdList Advantage
BTC Pharmaceutical CO. Ltd +86-15716293042 15716293042 info@btcpharm.com China 823 55
SHANGHAI SAGACHEM CO., LTD. 021-68404722 13816115801 david_si@shjlchem.com China 228 58
Shanghai Jin Yi Fine Chemical Co.,LTD 021-52801082 13918092929 jinyi_service@jyfinechem.com China 42 57
Hangzhou Copiore Chemical Co., Ltd. 17300981287 13757145729 sales@copiore.com China 289 58
Anhui Jianzhu Biotechnology Co., Ltd. 15855184105 3150278607@qq.com China 64 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd 18317105404 marketing002@witofly.com China 1600 58
Bayee Biotech (Anqing) Co., Ltd. 0556-5032306 18917961636 wtx@bayeebio.com China 145 61
Nanjing Jinhu Material Technology Co., Ltd 18021505668 sales@jinmat.com China 230 58
Creasyn Finechem(Tianjin) Co., Ltd. 022-83946278 13820372920 sales@creasyn.com China 968 68
Supplier Advantage
BTC Pharmaceutical CO. Ltd 55
SHANGHAI SAGACHEM CO., LTD. 58
Shanghai Jin Yi Fine Chemical Co.,LTD 57
Hangzhou Copiore Chemical Co., Ltd. 58
Anhui Jianzhu Biotechnology Co., Ltd. 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
Hangzhou Yaoruiyicheng Biological Medicine Co., Ltd 58
Bayee Biotech (Anqing) Co., Ltd. 61
Nanjing Jinhu Material Technology Co., Ltd 58
Creasyn Finechem(Tianjin) Co., Ltd. 68

Related articles

View Latest Price from 1-Boc-3-azetidinone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Boc-3-azetidinone pictures 2026-09-14 1-Boc-3-azetidinone
398489-26-4
 $100.00 1KG 99% 1000 KG HANGZHOU DINGYAN CHEM CO.,LTD
tert-Butyl 3-oxoazetidine-1-carboxylate pictures 2026-09-11 tert-Butyl 3-oxoazetidine-1-carboxylate
398489-26-4
 1KG ≥98.0% SHANGHAI SAGACHEM CO., LTD.
1-Boc-3-Azetidinone pictures 2026-05-28 1-Boc-3-Azetidinone
398489-26-4
 $1.00 1KG 99.% 50 ton Hebei Chuanghai Biotechnology Co,.LTD

1-Boc-3-azetidinone Spectrum

tert-Butyl 3-oxoazetidine-1-carboxylate(398489-26-4)1HNMRtert-Butyl 3-oxoazetidine-1-carboxylate(398489-26-4)FT-IR

398489-26-4 (1-Boc-3-azetidinone) Related Search:

N-Boc-3-aza-heptan-1-one tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate tert-Butyl 3-phenyl-L-alaninate hydrochloride tert-Butyl 3-allyl-4-oxopyrrolidine-1-carboxylate
2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate tert-Butyl (4-methylpiperidin-4-yl)carbamate tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate Theanine
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester,(3R,4R)-(9CI) Methyl 8-azabicyclo[3.2.1... (R)-2-Aminomethyl-4-boc-morpholine (S)-tert-Butyl 4,4-difluoro-2-(hydroxymethyl)-pyrrolidine-1-carboxylate (2R,4S)-N-alpha-t-Butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid
tert-Butyl 2-oxoazetidine-1-carboxylate Cyclobutanone 3-AZETIDINONE

1of4

1-BOC-3-AZETIDINONE Azetidin-3-one, N-BOC protected 95% tert-Butyl 3-oxoazetidine-1-carboxylate, 3-Oxoazetidine, N-BOC protected N-(t-butoxycarbonyl)azetidin-3-one tert-Butyl 3-oxoazetidine-1-carboxylat 1-Boc-3-azetidinone 97% 3-ketoazetidine-1-carboxylic acid tert-butyl ester 3-oxo-1-azetidinecarboxylic acid tert-butyl ester N-boc-3-azetidine 1-Boc-3-azetidione tert-Butyl 3-oxoazetidine-1-carb 1-Boc-3-azeetidinone Azetidin-3-one, N-BOC protected 3-OXOAZETIDINE, N-BOC PROTECTED 1-TERT-BUTOXYCARBONYL-3-AZETIDINONE 1-N-Boc-3-azetidinone 3-Oxoazetidine, N-BOC protected 95% 1-BOC-3-AZETIDINONE,97% N-BOC-3-OXOAZETIDINE 1-Azetidinecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester 1-BOC-3-OXOAZETIDINE 1-Boc-azetidin-3-one 1-Boc-3-acetidinone 3-Oxo-1-azetidinecarboxylic Acid 1,1-DiMethylethyl Ester tert-Butyl 3-Ox t-Butyl 3-oxoazetidine-1-carboxylate 1-Boc-3-azetidinone ,98% 1-(tert-Butoxycarbonyl)-3-azetidinone > Baricitinib-011 ert-Butyl3-oxoazetidine-1-carboxylate 3-Oxo-azetidine-1-BOC tert-butyl -3-oxozatidine-1-carboxylate 1-Boc azitidone CAS:398489-26-4 1-BOC-3-nitrogen-containing heterocyclic butanone N-Boc- 3-oxoazetidine 98% 1-BOC-3-Azetidinone - [A4482] Baricitinib Impurity 103 3-OXO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-Boc-3-azetidinone N-Boc-Azetidin-3-one TERT-BUTYL 3-OXOAZETIDINE-1-CARBOXYLATE 398489-26-4 398498-26-4 Amines Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Ring Systems pharmacetical Heterocycles series Azetidine pharmaceutical and biochemical