methyl 2-chlorothiazole-5-carboxylate
- CAS No.
- 72605-86-8
- Chemical Name:
- methyl 2-chlorothiazole-5-carboxylate
- Synonyms
- 5-Carbomethoxy-2-chlorothiazole;Methyl 2-chloro-thiazol-5-carboxylate;Methyl 2-chloro-5-thiazolecarboxylate;2-Chloro-5-(methoxycarbonyl)-1,3-thiazole;Methyl 2-chlorothiazole-5-carboxylate 97%;2-Chlorothiazole-5-carboxylic acid methyl ester;2-Chloro-5-thiazolecarboxylic acid methyl ester;2-Chloro-thiazole-5-Carbocylic acid methyl ester;5-Thiazolecarboxylic acid, 2-chloro-, Methyl ester;2-chloro-5-Thiazolecarboxylic acid methyl ester (9CI ACI)
- CBNumber:
- CB52521391
- Molecular Formula:
- C5H4ClNO2S
- Molecular Weight:
- 177.61
- MDL Number:
- MFCD09265500
- MOL File:
- 72605-86-8.mol
- MSDS File:
- SDS
| Boiling point | 271.2±32.0 °C(Predicted) |
|---|---|
| Density | 1.456±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | -1.09±0.10(Predicted) |
| form | powder |
| color | White |
| InChI | 1S/C5H4ClNO2S/c1-9-4(8)3-2-7-5(6)10-3/h2H,1H3 |
| InChIKey | ITGAFIAWKUGNIJ-UHFFFAOYSA-N |
| SMILES | [s]1c(ncc1C(=O)OC)Cl |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| WGK Germany | WGK 3 |
| HS Code | 2934100090 |
| Storage Class | 11 - Combustible Solids |
methyl 2-chlorothiazole-5-carboxylate price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SYX00302 | Methyl 2-chlorothiazole-5-carboxylate | 72605-86-8 | 1g | $114 | 2026-04-30 | Buy |
| Apolloscientific | OR15543 | Methyl 2-chloro-1,3-thiazole-5-carboxylate 95% | 72605-86-8 | 1g | $24 | 2026-06-04 | Buy |
| Matrix Scientific | 069592 | Methyl 2-chlorothiazole-5-carboxylate | 72605-86-8 | 1.00g | $100 | 2026-05-18 | Buy |
| Matrix Scientific | 069592 | Methyl 2-chlorothiazole-5-carboxylate | 72605-86-8 | 5.00g | $457 | 2026-05-18 | Buy |
| Synthonix | M2695 | Methyl 2-chlorothiazole-5-carboxylate 97% | 72605-86-8 | 1g | $20 | 2026-05-06 | Buy |
methyl 2-chlorothiazole-5-carboxylate Chemical Properties, Uses, Production
Synthesis
726185-57-5
72605-86-8
A suspension was prepared from methyl 2-aminothiazole-5-carboxylate hydrochloride (14.0 g, 71.927 mmol) in 8 ml of concentrated hydrochloric acid to which 20 g of crushed ice was added. An aqueous solution (30 ml) of sodium nitrite (5.0 g, 72.464 mmol) was added slowly and dropwise under external cooling conditions, ensuring that the reaction temperature was maintained below 0 °C at all times. After 30 min of reaction, copper(I) chloride (7.2 g, 72.735 mmol) was added and stirring was continued under cooling conditions for 1 h, followed by a slow warming up to room temperature over 1.5 h. The reaction was completed with the addition of ether. After completion of the reaction, the reaction mixture was thoroughly extracted with ether, the organic phases were combined, washed with saturated brine solution, dried over anhydrous sodium sulfate and the solvent was subsequently evaporated. Methyl 2-chlorothiazole-5-carboxylate 4.3 g (34% yield) was obtained as a colorless oil with a thin layer chromatographic Rf value of 0.94 (Unfolding agent: EI D). The product was used directly in the next reaction without further purification. Mass spectrometry analysis showed the molecular ion peak M+ = 177/179 (Cl isotope peak).
References
[1] Patent: US2004/192729, 2004, A1. Location in patent: Page 34
methyl 2-chlorothiazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1401 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 |
