Ethyl 2-chlorothiazole-5-carboxylate
- CAS No.
- 81449-93-6
- Chemical Name:
- Ethyl 2-chlorothiazole-5-carboxylate
- Synonyms
- Ethyl 2-chlorothiazole-5-carboxylate;Ethyl 2-chloro-5-thiazolecarboxylate;ethyl 2-chloro-1,3-thiazole-5-carboxylate;2-Chlorothiazole-5-carboxylic acid ethyl ester;2-Chloro-5-thiazolecarboxylic acid ethyl ester;5-Thiazolecarboxylicacid, 2-chloro-, ethyl ester
- CBNumber:
- CB1804128
- Molecular Formula:
- C6H6ClNO2S
- Molecular Weight:
- 191.64
- MDL Number:
- MFCD08703267
- MOL File:
- 81449-93-6.mol
- MSDS File:
- SDS
| Boiling point | 283.9±32.0 °C(Predicted) |
|---|---|
| Density | 1.383±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform; Dichloromethane; DMSO; Ethyl Acetate |
| pka | -0.98±0.10(Predicted) |
| form | Oil |
| color | Colorless |
| CAS DataBase Reference | 81449-93-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H315-H302 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501 |
| HS Code | 2934100090 |
Ethyl 2-chlorothiazole-5-carboxylate price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | CL2507 | ETHYL2-CHLORO-5-THIAZOLECARBOXYLATE 97% | 81449-93-6 | 5G | $24 | 2026-04-30 | Buy |
| AstaTech | CL2507 | ETHYL2-CHLORO-5-THIAZOLECARBOXYLATE 97% | 81449-93-6 | 25G | $114 | 2026-04-30 | Buy |
| AstaTech | CL2507 | ETHYL2-CHLORO-5-THIAZOLECARBOXYLATE 97% | 81449-93-6 | 100G | $364 | 2026-04-30 | Buy |
| Apolloscientific | OR953268 | Ethyl 2-chlorothiazole-5-carboxylate >98% | 81449-93-6 | 5g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR953268 | Ethyl 2-chlorothiazole-5-carboxylate >98% | 81449-93-6 | 25g | $92 | 2026-06-04 | Buy |
Ethyl 2-chlorothiazole-5-carboxylate Chemical Properties, Uses, Production
Uses
Ethyl 2-chlorothiazole-5-carboxylate is an intermediate in synthesizing 2-Chloro-5-thiazolecarboxylic Acid (C411465). It was studied as one of the metabolites of thiamethoxam, clothianidin, and dinotefuran in mice.
Synthesis
32955-21-8
81449-93-6
The general procedure for the synthesis of ethyl 2-chloro-1,3-thiazole-5-carboxylate from ethyl 2-aminothiazole-5-carboxylate was as follows: ethyl 2-aminothiazole-5-carboxylate (1.0 g, 6.35 mmol) was dissolved in a solvent mixture of acetonitrile (10 mL) and tetrahydrofuran (10 mL) at 23 °C. The solution was then slowly added to a mixture of acetonitrile (10 mL) and tetrahydrofuran (10 mL) containing butyl nitrite (1.3 mL, 9.52 mmol) and cuprous chloride (1.0 g, 7.6 mmol). The reaction mixture was to be heated at 65°C until thin layer chromatography (TLC) analysis (unfolding agent was 40% ethyl acetate-hexane) showed complete consumption of the raw materials. After completion of the reaction, the mixture was cooled to room temperature and extracted by partitioning between water and ethyl acetate. The organic layer was collected, concentrated under reduced pressure and finally purified by fast silica gel column chromatography with 20% ethyl acetate-hexane as eluent to afford the target product ethyl 2-chloro-1,3-thiazole-5-carboxylate (0.49 g, 40% yield).
References
[1] Patent: EP2615092, 2013, A1. Location in patent: Paragraph 0095; 0097
[2] Helvetica Chimica Acta, 1954, vol. 37, p. 2057,2064
[3] Helvetica Chimica Acta, 1944, vol. 27, p. 1432,1433
[4] Patent: WO2004/80996, 2004, A1. Location in patent: Page 26-27; 47
Ethyl 2-chlorothiazole-5-carboxylate Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. | 21-54820552 17702105771 | 188738128@qq.com | China | 300 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
View Latest Price from Ethyl 2-chlorothiazole-5-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-17 | Ethyl 2-chlorothiazole-5-carboxylate
81449-93-6
|
$5.00 | 1kg | ≥98% | 20mt/year | Jinan Finer Chemical Co., Ltd | |
 |
2020-01-13 | ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE
81449-93-6
|
$6.68 | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- Ethyl 2-chlorothiazole-5-carboxylate
81449-93-6
- $5.00
- ≥98%
- Jinan Finer Chemical Co., Ltd
-
- ETHYL 2-CHLOROTHIAZOLE-5-CARBOXYLATE
81449-93-6
- $6.68
- 97%-99%
- Career Henan Chemical Co
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