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(4-Chlorophenyl)(piperazin-1-yl) methanone

(4-Chlorophenyl)(piperazin-1-yl) methanone Structure
(4-Chlorophenyl)(piperazin-1-yl) methanone structure
CAS No.
54042-47-6
Chemical Name:
(4-Chlorophenyl)(piperazin-1-yl) methanone
Synonyms
1-(4-CHLOROBENZOYL)PIPERAZINE;(4-Chlorophenyl)(piperazin-1-yl) methanone;Methanone, (4-chlorophenyl)-1-piperazinyl-
CBNumber:
CB5253201
Molecular Formula:
C11H13ClN2O
Molecular Weight:
224.69
MDL Number:
MFCD01050442
MOL File:
54042-47-6.mol
MSDS File:
SDS
Last updated:2026-09-12 18:53:25
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(4-Chlorophenyl)(piperazin-1-yl) methanone Properties

Melting point 200 °C
Boiling point 384.0±37.0 °C(Predicted)
Density 1.231±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 8.32±0.10(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H335-H319-H302
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22-36

(4-Chlorophenyl)(piperazin-1-yl) methanone price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS114920 (4-Chlorophenyl)(piperazin-1-yl)methanone 95% 54042-47-6 1g $156 2026-06-04 Buy
Activate Scientific AS114920 (4-Chlorophenyl)(piperazin-1-yl)methanone 95% 54042-47-6 5g $489 2026-06-04 Buy
Matrix Scientific 305232 (4-Chlorophenyl)(piperazin-1-yl)methanone 54042-47-6 1.00g $115 2026-05-19 Buy
Matrix Scientific 305232 (4-Chlorophenyl)(piperazin-1-yl)methanone 54042-47-6 5.00g $361 2026-05-19 Buy
Matrix Scientific 305232 (4-Chlorophenyl)(piperazin-1-yl)methanone 54042-47-6 25.00g $994 2026-05-19 Buy
Product number Packaging Price Buy
AS114920 1g $156 Buy
AS114920 5g $489 Buy
305232 1.00g $115 Buy
305232 5.00g $361 Buy
305232 25.00g $994 Buy

(4-Chlorophenyl)(piperazin-1-yl) methanone Chemical Properties, Uses, Production

Synthesis

tert-Butyl 4-(4-chlorobenzoyl)piperazine-1-carboxylate

897445-35-1

(4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE

54042-47-6

Step 2: Synthesis of (4-chlorophenyl)(piperazin-1-yl)methanone (C) Dissolve tert-butyl 4-(4-chlorobenzoyl)piperazine-1-carboxylate (26 g) in dichloromethane (350 mL). To the solution was added 4 M hydrochloric acid/dioxane solution (150 mL). The reaction mixture was stirred at room temperature for 4 hours, during which time the formation of a white precipitate was observed. Upon completion of the reaction, the mixture was concentrated to remove the solvent. The resulting white solid was washed with ether. Subsequently, the white solid was treated with 1 N sodium hydroxide solution (200 mL) and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give the target product (4-chlorophenyl)(piperazin-1-yl)methanone (17.79 g, 99% yield). Product characterization data: 1H-NMR (hydrochloride, 300 MHz, MeOD): δ 2.80-2.90 (m, 4H), 3.20-3.80 (m, 4H), 7.29-7.36 (m, 4H).

References

[1] Patent: WO2006/71875, 2006, A1. Location in patent: Page/Page column 78
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 2, p. 1139 - 1148
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 16, p. 3739 - 3743
[4] Archiv der Pharmazie, 2017, vol. 350, # 8,
[5] Patent: CN107226807, 2017, A. Location in patent: Paragraph 0546-0548

(4-Chlorophenyl)(piperazin-1-yl) methanone synthesis

897445-35-1
54042-47-6
Synthesis of (4-Chlorophenyl)(piperazin-1-yl) methanone from tert-Butyl 4-(4-chlorobenzoyl)piperazine-1-carboxylate

(4-Chlorophenyl)(piperazin-1-yl) methanone Preparation Products And Raw materials

Raw materials

tert-Butyl 4-(4-chlorobenzoyl)piperazine-1-carboxylate Sodium hydroxide Hydrochloric acid 1,4-Dioxane Dichloromethane

Preparation Products

(4-Chlorophenyl)(piperazin-1-yl) methanone Suppliers

Global Suppliers ( 40)
Supplier Tel Email Country ProdList Advantage
Zhengzhou Guancheng Laboratory equipment Sales 0371-88888888 qq272369594;2159423853qq 2723695949@qq.com China 4991 50
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Yantai ShengKailun Chemical Technology Co., Ltd. 13356901049 3119594100@qq.com China 7964 55
Amatek Scientific Co. Ltd. 0512-56316828 400-867-5858;400-867-5858 info@amateksci.com China 28760 58
Hangzhou Molcore Biopharmatech Co.,Ltd 400-711-5280 86-571-81025280 sales@molcore.com China 9957 58
Aikon International Limited 025-58851090 13913916777 sales01@aikonchem.com China 15947 58
Suzhou Nuoouman Biological Technology Co., Ltd. 15026866316 180642609@qq.com China 4967 58
CR Corporation Limited fred.wen@crcorporation.cn China 8642 58
Career Henan Chemica Co +86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
Yuzhou Enthalpy Carbon Pharmaceutical Technology Co. LTD 19963477321; 19963477321 2041275825@qq.com China 1541 58
Supplier Advantage
Zhengzhou Guancheng Laboratory equipment Sales 50
Shanghai YuanYe Biotechnology Co., Ltd. 60
Yantai ShengKailun Chemical Technology Co., Ltd. 55
Amatek Scientific Co. Ltd. 58
Hangzhou Molcore Biopharmatech Co.,Ltd 58
Aikon International Limited 58
Suzhou Nuoouman Biological Technology Co., Ltd. 58
CR Corporation Limited 58
Career Henan Chemica Co 58
Yuzhou Enthalpy Carbon Pharmaceutical Technology Co. LTD 58

(4-Chlorophenyl)(piperazin-1-yl) methanone Spectrum

(4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE(54042-47-6)1HNMR

54042-47-6 ((4-Chlorophenyl)(piperazin-1-yl) methanone) Related Search:

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1-(4-CHLOROBENZOYL)PIPERAZINE Methanone, (4-chlorophenyl)-1-piperazinyl- (4-Chlorophenyl)(piperazin-1-yl) methanone 54042-47-6