(S)-1-(2-CHLOROPHENYL)ETHANOL
- CAS No.
- 131864-71-6
- Chemical Name:
- (S)-1-(2-CHLOROPHENYL)ETHANOL
- Synonyms
- (S)-1-(2-chlorophenyl)ethane;(S)-1-(2-CHLOROPHENYL)ETHANOL;(S)-2' chloro-alphaMethylbenzylalcohol;(S)-1-(2-chlorophenyl)ethanol(WXC09851);BenzeneMethanol, 2-chloro-α-Methyl-, (αS)-;(S)-1-(2-Chlorophenyl)ethanol, 98% (colorless) liquid;(S)-1-(2-CHLOROPHENYL)ETHANOL,(S)-1-(2-CHLOROPHENYL)ETHANOL
- CBNumber:
- CB5254091
- Molecular Formula:
- C8H9ClO
- Molecular Weight:
- 156.61
- MDL Number:
- MFCD06659506
- MOL File:
- 131864-71-6.mol
| Boiling point | 231℃ |
|---|---|
| Density | 1.182 |
| Flash point | 94℃ |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 14.05±0.20(Predicted) |
| Appearance | Colorless to light yellow Liquid |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1/C8H9ClO/c1-6(10)7-4-2-3-5-8(7)9/h2-6,10H,1H3/t6-/s3 |
| InChIKey | DDUBOVLGCYUYFX-ISZMHOAENA-N |
| SMILES | C1(C=CC=CC=1Cl)[C@H](C)O |&1:7,r| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264b-P270-P301+P312-P330-P403-P501c | |||||||||
| HS Code | 2906290090 | |||||||||
| NFPA 704 |
|
(S)-1-(2-CHLOROPHENYL)ETHANOL price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C992580 | (S)-1-(2-Chlorophenyl)ethanol | 131864-71-6 | 50mg | $45 | 2021-12-16 | Buy |
| Ark Pharm | P000038690 | (S)-1-(2-Chlorophenyl)ethanol 98% | 131864-71-6 | 1g | $114 | 2021-12-16 | Buy |
| ChemScene | CS-B0639 | Benzenemethanol,2-chloro-α-methyl-,(αS)- | 131864-71-6 | 1g | $127 | 2021-12-16 | Buy |
| Ark Pharm | P000038690 | (S)-1-(2-Chlorophenyl)ethanol 98% | 131864-71-6 | 100mg | $20 | 2021-12-16 | Buy |
| Ark Pharm | P000038690 | (S)-1-(2-Chlorophenyl)ethanol 98% | 131864-71-6 | 250mg | $38 | 2021-12-16 | Buy |
(S)-1-(2-CHLOROPHENYL)ETHANOL Chemical Properties,Uses,Production
Uses
It is an intermediate in organic syntheses and used as a pharmaceutical intermediates.
Synthesis
13524-04-4
13524-04-4
General procedure for the synthesis of 1-(2-chlorophenyl)ethanol from 1-(2-chlorophenyl)ethanol: Racemic alcohol (1o, 1.0 mmol) was dissolved in 5 mL of dichloromethane at -30 °C, and a compound of formula 2 (where R is I and n=2, and pharmaceutically acceptable salts thereof, 0.01 mol/mol) was added as catalyst. Subsequently, 0.7 equivalents of the methylsilylating agent Formula 5 (where R4 is methyl), 1 equivalent of potassium fluoride, and 80 mg of carboxylic acid-based ion exchange resin were added and the reaction mixture was stirred for 1 hour. Upon completion of the reaction, the mixture was filtered to recover the potassium fluoride and the ion exchange resin, and the filtrate was subsequently concentrated. The residue was purified by fast chromatography (eluent ratio acetone/hexane/triethylamine = 1:5:0.025) to afford the target product chiral alcohol (49% yield, enantiomeric excess value 98% ee, (S)-configuration).
References
[1] Patent: KR2015/114167, 2015, A. Location in patent: Paragraph 0359-0360
[2] Patent: KR2015/114445, 2015, A. Location in patent: Paragraph 0354; 0355; 0356; 0442
[3] Bulletin of the Chemical Society of Japan, 1996, vol. 69, # 4, p. 1079 - 1085
[4] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 16, p. 2397 - 2402
[5] ChemCatChem, 2015, vol. 7, # 24, p. 4016 - 4020
(S)-1-(2-CHLOROPHENYL)ETHANOL Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29733 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49730 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5744 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12580 | 58 |
View Lastest Price from (S)-1-(2-CHLOROPHENYL)ETHANOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-08-08 | (S)-1-(2-Chlorophenyl)ethanol
131864-71-6
|
US $30.00 / KG | 1KG | 99% | 200ton | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2019-07-10 | (S)-1-(2-CHLOROPHENYL)ETHANOL
131864-71-6
|
US $1.00 / KG | 1KG | 98% | 150KG | Career Henan Chemical Co |
-
- (S)-1-(2-Chlorophenyl)ethanol
131864-71-6
- US $30.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- (S)-1-(2-CHLOROPHENYL)ETHANOL
131864-71-6
- US $1.00 / KG
- 98%
- Career Henan Chemical Co
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