ChemicalBook >> CAS DataBase List >>3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one

3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one

3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one structure

CAS No.: 122080-99-3

Chemical Name:: 3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one

Synonyms: 3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one;Cis-3-Tosyl-3-Azabicyclo[3.2.0]Heptan-6-One;3-(Toluene-4-sulfonyl)-3-aza-bicyclo[3.2.0]heptan-6-one;3-(4-methylphenyl)sulfonyl-3-azabicyclo[3.2.0]heptan-6-one;3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one;3-Azabicyclo[3.2.0]heptan-6-one, 3-[(4-methylphenyl)sulfonyl]-

CBNumber:: CB52597864

Molecular Formula:: C13H15NO3S

Molecular Weight:: 265.33

MDL Number:: MFCD12911657

MOL File:: 122080-99-3.mol

MSDS File:: SDS

Last updated:2026-05-28 03:25:35

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3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one Properties

Boiling point	437.5±55.0 °C(Predicted)
Density	1.351±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
pka	-5.91±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338

3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	119683	3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one	122080-99-3	100.00mg	$74	2026-05-18	Buy
Matrix Scientific	119683	3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one	122080-99-3	250.00mg	$147	2026-05-18	Buy
Matrix Scientific	119683	3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one	122080-99-3	1.00g	$361	2026-05-18	Buy
aablocks	AA0016N5	3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one 97%	122080-99-3	100mg	$52	2026-05-28	Buy
aablocks	AA0016N5	3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one 97%	122080-99-3	250mg	$103	2026-05-28	Buy

Product number	Packaging	Price	Buy
119683	100.00mg	$74	Buy
119683	250.00mg	$147	Buy
119683	1.00g	$361	Buy
AA0016N5	100mg	$52	Buy
AA0016N5	250mg	$103	Buy

3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one Chemical Properties, Uses, Production

Synthesis

Benzenesulfonamide, 4-methyl-N-[3-oxo-3-(1-pyrrolidinyl)propyl]-N-2-propen-1-yl-

122080-91-5

3-(4-Methylbenzenesulfonyl)-3-
azabicyclo[3.2.0]heptan-6-one

122080-99-3

A 1,2-dichloroethane (250 mL) solution of Compound 6 (35 g, 0.10 mol) was slowly added dropwise over 20 minutes to a 1,2-dichloroethane (100 mL) solution of trifluoromethanesulfonic anhydride (58 g, 0.20 mol). Subsequently, a 1,2-dichloroethane (100 mL) solution of colistin (19 g, 0.15 mol) was added slowly over 30 minutes. The reaction mixture was heated to 90 °C and stirred for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated. The residue was hydrolyzed in the two-phase system H2O-CCl4. The organic layer was separated, dried with anhydrous Na2SO4, filtered and the filtrate evaporated to remove the solvent. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=10/1) to afford compound 7 (15 g, 54% yield) as a white solid.1H NMR (400 MHz, CDCl3): δ 2.45 (s, 3H), 2.67-2.72 (m, 1H), 2.85-2.92 (m, 1H), 2.94-3.00 (m, 2H), 3.27-3.35 (m, 1H), 3.59-3.66 (m, 2H), 3.17-3.12 (m, 2H), 3.83-3.86 (d, J=10Hz, 1H), 7.34-7.36 (d, J=8Hz, 2H), 7.69-7.71 (d, J=8.4Hz, 2H); MS calculated values: 265; MS measured value: 266 ([M+H]+).

References

[1] Patent: WO2015/38661, 2015, A1. Location in patent: Paragraph 0139

3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one Preparation Products And Raw materials

Raw materials

Benzenesulfonamide, 4-methyl-N-[3-oxo-3-(1-pyrrolidinyl)propyl]-N-2-propen-1-yl- 1,2-Dichloroethane Trifluoromethanesulfonic anhydride

Preparation Products

3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one Suppliers

Global Suppliers ( 30)

Supplier	Tel	Email	Country	ProdList	Advantage
JW & Y Pharmlab Co., Ltd.	021-64340559 13651849907	xinyu_shi@jwypharmlab.com.cn	China	9898	58
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Nantong MYBio-pharm. Co., Ltd.	0513-85921823 18662920231	sales@ntminyanmedical.com	China	4563	58
Cool Pharm, Ltd	021-60455363 18019463053	sales@coolpharm.com	China	8455	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Shanghai Pingguo Pharmaceutical Co., Ltd.	021-20432229	2412110556@qq.com	China	6016	55
Suzhou Ruichi Pharmaceutical Technology Co., Ltd.	0512-50152853	jjks1111@126.com	China	623	58
Aikon International Limited	025-58859352 13913916777	dt3@aikonchem.com	China	15490	58
Shanghai Benso Pharmaceutical Technology Co., Ltd.	13023173052	248775804@qq.com	China	4917	58
Shanghai zhigan biotechnology co., LTD		zhiqianbio@126.com	China	19765	58

Supplier	Advantage
JW & Y Pharmlab Co., Ltd.	58
Beijing Ouhe Technology Co., Ltd	60
Nantong MYBio-pharm. Co., Ltd.	58
Cool Pharm, Ltd	58
Amadis Chemical Company Limited	58
Shanghai Pingguo Pharmaceutical Co., Ltd.	55
Suzhou Ruichi Pharmaceutical Technology Co., Ltd.	58
Aikon International Limited	58
Shanghai Benso Pharmaceutical Technology Co., Ltd.	58
Shanghai zhigan biotechnology co., LTD	58

122080-99-3 (3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one) Related Search:

3-Azabicyclo[4.2.0]octan-8-one, 3-[(4-methylphenyl)sulfonyl]-, cis- (9CI) 3-Azabicyclo[4.1.0]heptane-6-carboxaldehyde, 7-methyl-3-[(4-methylphenyl)sulfonyl]-, (1R,6R)- 1-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-3,5-dimethylpiperidine N-Isopropyl-1-[(4-methylphenyl)sulfonyl]-4-piperidinecarboxamide (1S,5S)-2-Tosyl-2-azabicyclo[3.3.1]nonan-6-one

4-(Pyrrolidine-1-sulfonyl)-benzaldehyde

1of2

3-(4-Methylbenzenesulfonyl)-3- azabicyclo[3.2.0]heptan-6-one 3-Tosyl-3-azabicyclo[3.2.0]heptan-6-one 3-(Toluene-4-sulfonyl)-3-aza-bicyclo[3.2.0]heptan-6-one Cis-3-Tosyl-3-Azabicyclo[3.2.0]Heptan-6-One 3-(4-methylphenyl)sulfonyl-3-azabicyclo[3.2.0]heptan-6-one 3-Azabicyclo[3.2.0]heptan-6-one, 3-[(4-methylphenyl)sulfonyl]- 122080-99-3